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Michael Anthony McDevitt, M.D.


Appointment Phone


Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-3142

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-955-3142
Fax: 410-614-0854


Acute Myeloid Leukemia, Anemias, Atypical Chronic Myeloid Leukemia (aCML), Chronic Myelomonocytic Leukemia , Medical Oncology, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm (BCR-ABL Negative), Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable , Myelodysplastic/Myeloproliferative Neoplasms, Myeloproliferative Disorders, Primary Myelofibrosis, Secondary Myelofibrosis, Thrombocytopenias


Dr. Michael McDevitt is an assistant professor of medicine and oncology at the Johns Hopkins University School of Medicine. He specializes in the class evaluation of anemias, thrombocytopenias and other hematology disorders. Dr. McDevitt is on the faculty of the Hematology/Medical Oncology Fellowship Program at Johns Hopkins.

Dr. McDevitt received his undergraduate degree in chemistry from Case Western Reserve University. He earned his Ph.D. in molecular cell biology from Rockefeller University and his M.D. from Cornell University Medical College. He completed his residency at Johns Hopkins and performed a fellowship in hematology and oncology at Brigham and Women's Hospital. Dr. McDevitt joined the Johns Hopkins faculty in 2002.

Prior to joining Johns Hopkins, Dr. McDevitt was an assistant investigator and director of the Department of Experimental Hematology at North Shore-LIJ’s Center for Genomics and Human Genetics.

His research focuses on unraveling the acquired genetic and epigenetic changes that lead to poor prognosis myeloid disorders. more

    Additional Information

  • Education +


    • Cornell University Medical College / MD (1989)


    • Johns Hopkins University School of Medicine / Medicine (1992)


    • Brigham and Women's Hospital / Hematology and Oncology (1996)
  • Research & Publications +

    Research Summary

    Dr. McDevitt's research focuses on unraveling the acquired genetic and epigenetic changes that lead to poor prognosis myeloid disorders. The long term goals include:

    1. Identify underlying pathways of deregulation to ultimately allow effective therapeutic targeting.
    2. Develop more sensitive and accurate biomarkers that improve diagnostic classification and prognostication and can be used in translational clinical trials.
    3. Apply these findings in early phase clinical trials for patients with accelerating myeloproliferative disorders and mixed myelodysplastic syndrome/myeloproliferative disorders. Of particular current interest are DNA repair pathways and Parp inhibitors.

    Key collaborators include Judith Karp, Keith Pratz, James Herman, Alison Moliterno, Doug Smith, Hetty Carraway, Steve Gore, Cliff Takemoto, Scott Kaufmann (Mayo Clinic), and Jaroslaw Maciejewski (Cleveland Clinic).

    Selected Publications

    Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP. "Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A." Blood. 2011 Oct 6;118(14):3932-41. doi: 10.1182/blood-2010-10-311019. Epub 2011 Aug 9.

    Stein BL, Williams DM, O'Keefe C, Rogers O, Ingersoll RG, Spivak JL, Verma A, Maciejewski JP, McDevitt MA, Moliterno AR. "Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes." Haematologica. 2011 Oct;96(10):1462-9. doi: 10.3324/haematol.2011.045591. Epub 2011 Jun 28.

    Tiu RV, Gondek LP, O'Keefe CL, Elson P, Huh J, Mohamedali A, Kulasekararaj A, Advani AS, Paquette R, List AF, Sekeres MA, McDevitt MA, Mufti GJ, Maciejewski JP. "Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies." Blood. 2011 Apr 28;117(17):4552-60. doi: 10.1182/blood-2010-07-295857. Epub 2011 Feb 1.

  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Internal Medicine/Hematology, Clinical Clerkship (Course Director)

  • Activities & Honors +
  • Videos & Media +
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