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Gary Gerstenblith, MD

Director of clinical trials, Division of Cardiology
Professor of Medicine

See Research on Pubmed

Male
Appointment Phone

443-997-0270

Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director of clinical trials, Division of Cardiology
  • Professor of Medicine

Centers & Institutes

  • Ciccarone Center for Prevention of Heart Disease
  • Heart and Vascular Institute

Expertise

Cardiology, Cardiovascular Disease, Coronary Artery Disease, Coronary Care Unit, Heart Disease

Technology Expertise

Cardiovascular Aging, Coronary Artery Disease

Biography

Dr. Gary Gerstenblith is professor of medicine and director of clinical trials in the Johns Hopkins Medicine Division of Cardiology. He also serves as attending physician in r the Cardiology care Unit.

Dr. Gerstenblith earned his undergraduate degree from New York University and his medical degree from the University of Pennsylvania School of Medicine. After working at the National Institute on Aging and the National Institutes of Health (NIH) and completing a fellowship at Jackson Memorial Hospital in Miami, Dr. Gerstenblith joined the faculty of the Johns Hopkins University School of Medicine.

Dr. Gerstenblith conducts clinical trials in patients with cardiovascular disease. His research interests include the impact of cardiovascular aging on cardiac structure and function, and the use of stem cells to repair damaged cardiac muscle. He has published nearly 250 articles and book chapters and has been a referee for numerous journals including Circulation, The New England Journal of Medicine and The Journal of the American College of Cardiology.

Languages

  • English

Memberships

American Heart Association

American Federation for Clinical Research

American College of Physicians

Association of University Cardiologists

Society of Magnetic Resonance in Medicine

The Johns Hopkins Medical and Surgical Association

Clinical Trial Keywords

  • coronary endothelial function
  • coronary artery disease
  • Xanthine oxidase inhibition

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Pennsylvania Health System School of Medicine (Philadelphia PA) (1971)

    Residencies

    • Hospital of the University of Pennsylvania / Medicine (Philadelphia PA) (1973)

    Fellowships

    • University of Miami School of Medicine / Cardiology (Miami FL) (1977)

    Certifications

    • American Board of Internal Medicine / Cardiovascular Disease (1977)
    • American Board of Internal Medicine / Internal Medicine (1974)
  • Research & Publications +

    Selected Publications View all on PubMed

    Hirsch GA, Bottonley P, Gerstenblith G, Weiss RG. Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. JACC 59:802-8, 2012.

    Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marban L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marban E. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CACUCEUS): a prospective, randomised phase 1 trial. Lancet 379:895-904, 2012.

    Karantalis V, DiFede DL, Gerstenblith G, Pham S, Symes J, Zambrano JP, Fishman J, Pattany P, McNiece I, Conte J, Schulman S, Wu K, Shah A, Breton E, Davis-Sproul J, Schwarz R, Feigenbaum G, Mushtaq M, Suncion VY, Lardo AC, Borrello I, Mendizabal A, Karas TZ, Byrnes J, Lowery M, Heldman AW, Hare JM. Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) trial. Circ Res 114:1302-10, 2014.

    Bottomley PA, Panjrath GS, Lai S, Hirsch GA, Wu K, Najjar SS, Steinberg A, Gerstenblith G, Weiss RG. Metabolic rates of ATP transfer through creatine kinase (CK flux) predict clinical heart failure events and death. Sci Transl Med 5:215re3, 2013.

    Hays AG, Stuber M, Hirsch GA, Yu J, Schar M, Weiss RG, Gerstenblith G, Kelle S. Non-invasive detection of coronary endothelial response to sequential handgrip exercise in coronary artery disease patients and healthy adults. PLos ONE 8(3):e58047, 2013.

    Assayag M, Saada A. Gerstenblith G, Canaana H, Shlomai R, Horowitz M. Mitochondrial performance in heat acclimation—a lesson from ischemia/reperfusion and calcium overload insults in the heart. Am J Physiol 303:R870-81, 2012.

    Hare JM, Fishman JE, Gerstenblith G, DiFede Velazquez DL, Zambrano JP, Suncion VY, Tracy M, Ghersin E, Johnston PV, Brinker JA, Breton E, Davis-Sproul J. Schulman IH, Byrnes J, Mendizabal AM, Lowery MH, Rouy D, Altman P, Wong Po Foo C, Ruiz P, Amador A, Da Silva J, McNiece IK, Heldman AW. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA 308:2369-79, 2012.

    Barth AS, Zhang Y, Li T, Smith RR, Chimenti I, Terrovitis I, Davis DR, Kizana E, Ho AS, O’Rourke B, Wolff AC, Gerstenblith G, Marban E. Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab. Stem Cells Transl Med 1:289-97, 2012.

    Hirsch GA, Bottonley P, Gerstenblith G, Weiss RG. Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. JACC 59:802-8, 2012.

    Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marban L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marban E. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CACUCEUS): a prospective, randomised phase 1 trial. Lancet 379:895-904, 2012.

    Gupta A, Akki A, Wang Y, Leppo MK, Chacko VP, Foster DB, Caceres V, Shi S, Kirk JA, Su J, Lai S, Paolocci N, Steenbergen C, Gerstenblith G, Weiss RG. Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. J Clin Invest 122:291-302, 2012.

    Wu KC, Gerstenblith G, Guallar E, Marine JE, Dalal D, Cheng A, Marban E, Lima JA, Tomaselli GF, Weiss RG. Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging 5:178-86, 2012.

    Clinical Trials

    Impact of xanthine oxidase inhibition on coronary endothelial function

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Fellow (FACC) American College of Cardiology

    Who’s Who in Medicine and Healthcare Marquis Who’s Who

    Phi Beta Kappa (New York University)

    Alpha Omega Alpha (University of Pennsylvania School of Medicine)

    Fellow, American College of Chest Physicians

    Fellow, American College of Legal Medicine

    Professional Activities

    1983 ‑ 1988: Peer‑Review Subcommittee American Heart Association ‑ Maryland Affiliate, Inc.

    1988‑1990: Research Committee American Heart Association ‑ Maryland Affiliate, Inc.

    1993-1997: Chairman, Committee on Cardiovascular Disease in the Elderly, American Heart Association

    1993-1997: Executive Committee, Council on Clinical Cardiology, American Heart Association

    2000 - 2008: Board of Directors, The Stanley J. Sarnoff Endowment for Cardiovascular Science, Inc.

    National Scientific Advisory Council of the American Federation for Aging Research

  • Videos & Media +

    Videos

    Stem Cell Implants to Repair Damaged Hearts, Part I

    Stem Cell Implants to Repair Damaged Hearts, Part II

  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-6835
    Appointment Phone: 443-997-0270
    Location Map

    Department/Division

    • Medicine - Cardiology

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