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Photo of Dr. Jimmie T Sylvester, M.D.

Jimmie T Sylvester, M.D.


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »



Johns Hopkins Outpatient Center

Appointment Phone: 410-955-3467

601 N. Caroline Street
Baltimore, MD 21287 map

The Johns Hopkins Hospital

Appointment Phone: 410-955-3467

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864

4940 Eastern Avenue
Baltimore, MD 21224 map


Critical Care Medicine , Pulmonary Disease and Critical Care Medicine

Research Interests

Calcium signaling in hypoxic pulmonary vasoconstriction; Chronic hypoxia and pulmonary vascular smooth muscle; Pulmonary arterial responses to hypoxia

    Additional Information

  • Education +


    • Stanford University School of Medicine / M.D.; Medicine (1969)


    • Johns Hopkins University School of Medicine / Medicine (1971)


    • Johns Hopkins Bloomberg School of Public Health / Environmental Health Sciences (1973)
    • Johns Hopkins University School of Medicine / Pulmonary Diseases (1974)


    • American Board of Internal Medicine / Internal Medicine (1974)
    • American Board of Internal Medicine / Pulmonary Disease (1980)
  • Research & Publications +

    Selected Publications View all on PubMed

    1. Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15;304(8):L549-61. doi: 10.1152/ajplung.00081.2012. Epub 2013 Feb 15. PMID: 23418090
    2. Mitzner W, Sylvester JT. In memoriam Dr Solbert Permutt, 1925–2012. Eur Respir J. 2012 Oct;40(4):811-3. No abstract available. PMID: 23193573
    3. Leggett K, Maylor J, Undem C, Lai N, Lu W, Schweitzer K, King LS, Myers AC, Sylvester JT, Sidhaye V, Shimoda LA. Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L343-53. doi: 10.1152/ajplung.00130.2012. Epub 2012 Jun 8. PMID: 22683574
    4. Wang J, Shimoda LA, Sylvester JT. Ca2+ responses of pulmonary arterial myocytes to acute hypoxia require release from ryanodine and inositol trisphosphate receptors in sarcoplasmic reticulum. Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L161-8. doi: 10.1152/ajplung.00348.2011. Epub 2012 May 11. PMID: 22582116
    5. Luke T, Maylor J, Undem C, Sylvester JT, Shimoda LA. Kinase-dependent activation of voltage-gated Ca2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1128-39. doi: 10.1152/ajplung.00396.2011. Epub 2012 Mar 2. PMID: 22387294
    6. Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1239-44. doi: 10.1073/pnas.1120385109. Epub 2012 Jan 9. PMID: 22232678
    7. Sylvester JT, Shimoda LA, Aaronson PI, Ward JP. Hypoxic pulmonary vasoconstriction. Physiol Rev. 2012 Jan;92(1):367-520. doi: 10.1152/physrev.00041.2010. Review. PMID: 22298659
    8. Weigand L, Shimoda LA, Sylvester JT. Enhancement of myofilament calcium sensitivity by acute hypoxia in rat distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 2011 Sep;301(3):L380-7. doi: 10.1152/ajplung.00068.2011. Epub 2011 Jun 10. PMID: 21665962
  • Academic Affiliations & Courses +
  • Activities & Honors +
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