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Jimmie T Sylvester, M.D.

Photo of Dr. Jimmie T Sylvester, M.D.

Professor of Medicine

Male

Expertise: Critical Care Medicine, Pulmonary Disease and Critical Care Medicine

Research Interests: Calcium signaling in hypoxic pulmonary vasoconstriction; Chronic hypoxia and pulmonary vascular smooth muscle; Pulmonary arterial responses to hypoxia ...read more

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410-955-3467
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410-464-6641
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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-3467

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center
Appointment Phone: 410-955-3467

601 N. Caroline St.
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-550-5864

4940 Eastern Avenue
Baltimore, MD 21224 map

Background

Dr. Jimmie Sylvester is a professor emeritus of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pulmonary disease and critical care medicine.

Dr. Sylvester earned his M.D. from the Stanford University School of Medicine. He completed his residency and performed a fellowship in pulmonary diseases at Johns Hopkins. He also performed a fellowship in environmental health sciences at the Johns Hopkins Bloomberg School of Public Health.

His research interests include calcium signaling in hypoxic pulmonary vasoconstriction, chronic hypoxia and pulmonary vascular smooth muscle, and pulmonary arterial responses to hypoxia.

...read more

Titles

  • Professor of Medicine
  • Joint Appointment in Anesthesiology and Critical Care Medicine

Education

Degrees

  • MD; Medicine, Stanford University School of Medicine (1969)

Residencies

  • Johns Hopkins University School of Medicine / Medicine (1971)

Fellowships

  • Johns Hopkins Bloomberg School of Public Health / Environmental Health Sciences (1973)
  • Johns Hopkins University School of Medicine / Pulmonary Diseases (1974)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (1974)
  • American Board of Internal Medicine / Pulmonary Disease (1980)

Research & Publications

Selected Publications

View all on Pubmed

Mitzner W, Sylvester JT. In memoriam Dr Solbert Permutt, 1925–2012. Eur Respir J. 2012 Oct;40(4):811-3. No abstract available. PMID: 23193573

Leggett K, Maylor J, Undem C, Lai N, Lu W, Schweitzer K, King LS, Myers AC, Sylvester JT, Sidhaye V, Shimoda LA. Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L343-53. doi: 10.1152/ajplung.00130.2012. Epub 2012 Jun 8. PMID: 22683574

Wang J, Shimoda LA, Sylvester JT. Ca2+ responses of pulmonary arterial myocytes to acute hypoxia require release from ryanodine and inositol trisphosphate receptors in sarcoplasmic reticulum. Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L161-8. doi: 10.1152/ajplung.00348.2011. Epub 2012 May 11. PMID: 22582116

Luke T, Maylor J, Undem C, Sylvester JT, Shimoda LA. Kinase-dependent activation of voltage-gated Ca2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1128-39. doi: 10.1152/ajplung.00396.2011. Epub 2012 Mar 2. PMID: 22387294

Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1239-44. doi: 10.1073/pnas.1120385109. Epub 2012 Jan 9. PMID: 22232678

Sylvester JT, Shimoda LA, Aaronson PI, Ward JP. Hypoxic pulmonary vasoconstriction. Physiol Rev. 2012 Jan;92(1):367-520. doi: 10.1152/physrev.00041.2010. Review. PMID: 22298659

Weigand L, Shimoda LA, Sylvester JT. Enhancement of myofilament calcium sensitivity by acute hypoxia in rat distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 2011 Sep;301(3):L380-7. doi: 10.1152/ajplung.00068.2011. Epub 2011 Jun 10. PMID: 21665962

Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15;304(8):L549-61. doi: 10.1152/ajplung.00081.2012. Epub 2013 Feb 15. PMID: 23418090

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