Skip Navigation
Find a Doctor


Search for
other physicians or researchers.

Find a Doctor
Photo of Dr. Jimmie T Sylvester, MD

Jimmie T Sylvester, MD

Professor of Medicine

See Research on Pubmed

Appointment Phone


Primary Location

The Johns Hopkins Hospital

View All Locations
Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Professor of Medicine


Critical Care Medicine, Pulmonary Disease and Critical Care Medicine

Research Interests

Pulmonary arterial responses to hypoxia; Chronic hypoxia and pulmonary vascular smooth muscle; Calcium signaling in hypoxic pulmonary vasoconstriction


  • English
Additional Resources +
  • Education +


    • Stanford University School of Medicine ( Stanford CA ) (1969)


    • The Johns Hopkins Hospital/Medicine ( Baltimore MD ) (1971)


    • Johns Hopkins University School of Medicine/Pulmonary Diseases ( Baltimore MD ) (1974)
    • Johns Hopkins University Bloomberg School of Public Health/Environmental Health Sciences ( Baltimore MD ) (1973)


    • Pulmonary Disease, American Board of Internal Medicine (1980)
    • Internal Medicine, American Board of Internal Medicine (1974)
  • Research & Publications +

    Selected Publications View all on PubMed

    1. Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15;304(8):L549-61. doi: 10.1152/ajplung.00081.2012. Epub 2013 Feb 15. PMID: 23418090 
    2. Mitzner W, Sylvester JT. In memoriam Dr Solbert Permutt, 1925–2012. Eur Respir J. 2012 Oct;40(4):811-3. No abstract available. PMID: 23193573 
    3. Leggett K, Maylor J, Undem C, Lai N, Lu W, Schweitzer K, King LS, Myers AC, Sylvester JT, Sidhaye V, Shimoda LA. Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L343-53. doi: 10.1152/ajplung.00130.2012. Epub 2012 Jun 8. PMID: 22683574 
    4. Wang J, Shimoda LA, Sylvester JT. Ca2+ responses of pulmonary arterial myocytes to acute hypoxia require release from ryanodine and inositol trisphosphate receptors in sarcoplasmic reticulum. Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L161-8. doi: 10.1152/ajplung.00348.2011. Epub 2012 May 11. PMID: 22582116 
    5. Luke T, Maylor J, Undem C, Sylvester JT, Shimoda LA. Kinase-dependent activation of voltage-gated Ca2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1128-39. doi: 10.1152/ajplung.00396.2011. Epub 2012 Mar 2. PMID: 22387294 
    6. Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1239-44. doi: 10.1073/pnas.1120385109. Epub 2012 Jan 9. PMID: 22232678 
    7. Sylvester JT, Shimoda LA, Aaronson PI, Ward JP. Hypoxic pulmonary vasoconstriction. Physiol Rev. 2012 Jan;92(1):367-520. doi: 10.1152/physrev.00041.2010. Review. PMID: 22298659
    8. Weigand L, Shimoda LA, Sylvester JT. Enhancement of myofilament calcium sensitivity by acute hypoxia in rat distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 2011 Sep;301(3):L380-7. doi: 10.1152/ajplung.00068.2011. Epub 2011 Jun 10. PMID: 21665962
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Upcoming Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-3467
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-955-3467
    Location Map
    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-550-5864
    Location Map


    • Medicine - Pulmonary and Critical Care Medicine

Is This You? Edit Profile


© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer