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Robert Kurman, M.D.

Photo of Dr. Robert Kurman, M.D.

Director, Division of Gynecologic Pathology

Professor of Pathology

Male

Expertise: Pathology

Research Interests: Morphologic and genetic alterations of early events in carcinogenesis; Neoplasms in the female genital tract; High-grade serous carcinomas; Ovarian cancer genesis ...read more

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Locations

The Johns Hopkins Hospital
Appointment Phone: 443-287-4966

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 443-287-4996

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-955-0471

401 N. Broadway
Baltimore, MD 21231 map

Background

Dr. Robert Kurman is a professor of gynecology and obstetrics, oncology and pathology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include gynecologic pathology, and he is an expert at diagnosing borderline ovarian tumors. Dr. Kurman serves as the director of the Division of Gynecologic Pathology.

Dr. Kurman received his M.D. from SUNY Upstate Medical University. He completed a residency in pathology from Brigham and Women''s Hospital, a residency in obstetrics and gynecology from Boston City Hospital, and a residency in obstetrics and gynecology from the University of Southern California Keck School of Medicine. He performed a fellowship at Massachusetts General Hospital.

He was recently awarded a multimillion-dollar Ovarian Cancer Research Program Consortium Award from the Department of Defense’s Congressionally Directed Medical Research Program to study where high-grade serous carcinomas originate. He and his team are trying to prove that most ovarian cancer originates in the fallopian tubes.

...read more

Titles

  • Director, Division of Gynecologic Pathology
  • Professor of Pathology
  • Professor of Gynecology and Obstetrics
  • Professor of Oncology

Education

Degrees

  • MD, SUNY Upstate Medical University (1968)

Residencies

  • Brigham and Women's Hospital / Pathology (1971)
  • Boston City Hospital / Obstetrics and Gynecology (1973)
  • University of Southern California Keck School of Medicine / Obstetrics and Gynecology (1978)

Fellowships

  • Massachusetts General Hospital (1972)

Board Certifications

  • American Board of Obstetrics and Gynecology / Obstetrics And Gynecology (1980)
  • American Board of Pathology / Anatomic Pathology (1972)

Research & Publications

Research Summary

Dr. Kurman and his team research the pathogenesis of a variety of neoplasms in the female genital tract with a particular focus on the morphologic and genetic alterations associated with the early events in carcinogenesis.

Dr. Kurman recently received a multimillion-dollar Ovarian Cancer Research Program Consortium Award from the Department of Defense’s Congressionally Directed Medical Research Programs to study where high-grade serous carcinomas originate, which will aid in developing strategies for preventing these deadly cancers.

Evidence from a recent study by Kurman and his colleagues suggests that ovarian cancer might begin in the fallopian tube but that the cancerous cells shed into an ovary, where they grow. If his further studies prove this to be true, women at high risk could have their tubes or the part of their tubes where the precancerous lesions develop surgically removed. That would reduce their risk of developing ovarian cancer while preserving their fertility and maintaining their source of disease-preventing hormones.

Selected Publications

  1. Mao, T.L.; Hsu, C.Y.; Yen, M.J.; Gilks, B.; Sheu, J.J.; Gabrielson, E.; Vang, R.; Cope, L.; Kurman, R.J.; Wang, T.L.; Shih Ie, M. Expression of Rsf-1, a chromatin-remodeling gene, in ovarian and breast carcinoma. Hum Pathol. 2006 Sep;37(9):1169-1175.
  2. Nakayama, K.; Nakayama, N.; Davidson, B.; Katabuchi, H.; Kurman, R.J.; Velculescu, V.E.; Shih Ie, M.; Wang, T.L. Homozygous deletion of MKK4 in ovarian serous carcinoma. Cancer Biol Ther. 2006 Jun;5(6):630-634.
  3. Nakayama, K.; Nakayama, N.; Kurman, R.J.; Cope, L.; Pohl, G.; Samuels, Y.; Velculescu, V.E.; Wang, T.L.; Shih Ie, M. Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther. 2006 Jul;5(7):779-785.
  4. Park, J.T.; Li, M.; Nakayama, K.; Mao, T.L.; Davidson, B.; Zhang, Z.; Kurman, R.J.; Eberhart, C.G.; Shih Ie, M.; Wang, T.L. Notch3 gene amplification in ovarian cancer. Cancer Res. 2006 Jun 15;66(12):6312-6318.
  5. Kurman, R.J.; Visvanathan, K.; Roden, R.; Wu, T.C.; Shih Ie, M. Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis. Am J Obstet Gynecol. 2008 Apr;198(4):351-356.
  6. Gross, A.L.; Kurman, R.J.; Vang, R.; Shih Ie, M.; Visvanathan, K. Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. J Oncol. 2010;2010:126295.
  7. Kuo, K.T.; Mao, T.L.; Chen, X.; Feng, Y.; Nakayama, K.; Wang, Y.; Glas, R.; Ma, M.J.; Kurman, R.J.; Shih Ie, M.; Wang, T.L. DNA copy numbers profiles in affinity-purified ovarian clear cell carcinoma. Clin Cancer Res. 2010 Apr 1;16(7):1997-2008.
  8. Shih Ie, M.; Chen, L.; Wang, C.C.; Gu, J.; Davidson, B.; Cope, L.; Kurman, R.J.; Xuan, J.; Wang, T.L. Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis. Am J Obstet Gynecol. 2010 Dec;203(6):584 e581-522.

Silverberg SG, Kurman RJ. Atlas of Tumor Pathology. Tumors of the Uterine Corpus and Gestational Trophoblastic Disease, Third Series, Fascicle 3, Armed Forces Institute of Pathology, Washington, D.C., 1992.

Kurman RJ, Norris HJ, Wilkinson E. Atlas of Tumor Pathology. Tumors of the Cervix, Vagina and Vulva, Third Series, Fascicle 4, Armed Forces Institute of Pathology, Washington, D.C., 1992.


Mazur MT, Kurman RJ. Diagnosis of Endometrial Biopsies and Curettings. Apractical Approach, Springer-Verlag, New York, 1995.

Kurman RJ (ed): Blaustein's Pathology of The Female Genital Tract. 5thed., Springer-Verlag, New York, 2002.

Activities & Honors

Honors

  • Ovarian Cancer Research Program Consortium Award, Department of Defense's Congressionally Directed Medical Research Program
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