Research & Publications +
Dr. Clark''s current research interests are focused in the area of cancer diagnostics. Dr. Clarks laboratory is interested in the molecular characterization of cellular damage and the discovery of novel biomarkers for cancer. The translational arm of his research laboratory is interested in characterizing molecular alterations in cytologic samples of human tumors and developing molecular biomarkers to guide targeted cancer therapy.
Filie AC, Asa S, Geisenger KR, Logani S, Merino M, Nikiforov YE, Clark DP: Utilization of Ancillary Studies in Thyroid Fine Needle Aspirates: A Synopsis of the National Cancer Institute* Thyroid Fine Needle Aspiration State of the Science Conference. Diagn Cytopathol 2008; 36(6):438-441.
Murphy KM, Chen F, Clark DP: Identification of immunohistochemical biomarkers for papillary thyroid carcinoma using gene expression profiling. Human Pathol, 2008; 39(3): 420-426.
Baloch ZW, Cibas ES, Clark DP, Layfield LJ, Ljung B-M, Pitman MB, Abati, A: The National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference: A Summation. Cytojournal 2008; 5(1):6.
Kelly D, Kincaid E, Fansler Z, Rosenthal, Clark DP: Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProExTM C). Cancer (Cancer Cytopathol) 2006;108:494-500.
Jimeno A, Kulesza P, Wheelhouse J, Chan A, Zhang X, Kincaid E, Chen R, Clark DP, Forastiere A, Hidalgo M: Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy. Bri J Cancer 2007; 96: 952-959.
Jimeno A, Kulesza P, Kincaid E, Bouaroud N, Chan A, Forastiere A, Brahmer J, Clark DP, Hidalgo M: C-fos assessment as a marker of anti-epidermal growth factor receptor effect. Cancer Res 2006 66(4):2385-2390.
Yang B, Guo M, Herman JG, and Clark DP: Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163(3):1101-1107, 2003.