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Photo of Dr. David Valle

David Lee Valle, M.D.

Director, Institute of Genetic Medicine
Professor of Pediatrics

Male

Appointment Phone

410-955-4260

Main Location

The Johns Hopkins Hospital

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Titles

  • Director, Institute of Genetic Medicine
  • Henry J. Knott Professor
  • Professor of Pediatrics
  • Joint Appointment in Medicine
  • Joint Appointment in Molecular Biology and Genetics
  • Professor of Ophthalmology

Centers & Institutes

Departments

  • Medicine
  • Molecular Biology and Genetics
  • Ophthalmology
  • Pathology
  • Pediatrics - Genetics

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-955-4260

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-4260
Fax: 410-955-7397

Expertise

Medical Genetics

Research Interests

Clinical, biochemical, and molecular bases of disease; Genetic factors in neuropsychiatric disease; Inborn errors of metabolism; Medical sequencing, genome sequencing and comparative genomics

Biography

Dr. David Valle is the director of the Institute of Genetic Medicine and professor of pediatrics and ophthalmology at the Johns Hopkins School of Medicine. He also serves as a geneticist for the Johns Hopkins Children’s Center and is board-certified by the American Board of Medical Genetics in clinical molecular genetics, clinical biochemical genetics, clinical genetics and pediatrics.

Dr. Valle holds a bachelor’s degree and medical degree from Duke University. He completed a pediatric residency at Johns Hopkins University before joining the Johns Hopkins faculty. He is a member of the Large Scale Sequencing Committee and the Large Scale Sequencing Advisory Committee at the National Human Genome Research Institute. He is also a member of the Institute of Medicine of the National Academy of Sciences, a fellow of the American Association for the Advancement of Science and the past president of the American Society of Human Genetics.

Dr. Valle also serves as director of the Predoctoral Training Program in Human Genetics, as well as co-director of the Genes to Society program.
In 2007, Dr. Valle was recognized in Baltimore magazine as one of the city’s top docs.

 

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    Additional Information

  • Education +

    Degrees

    • Duke University School of Medicine / MD (1969)

    Residencies

    • Johns Hopkins University School of Medicine / Pediatrics (1971)
    • Johns Hopkins University School of Medicine / Pediatrics (1975)

    Certifications

    • American Board of Medical Genetics / Clinical Biochemical Genetics (1982)
    • American Board of Medical Genetics / Clinical Genetics / MD (1982)
    • American Board of Medical Genetics / Clinical Molecular Genetics (1993, 2010)
    • American Board of Pediatrics / Pediatrics (1978)
  • Research & Publications +

    Research Summary

    In the broadest sense, my research interests include understanding all aspects of the role of genetic factors in human health and disease. In particular, our studies involve clinical, biochemical, molecular and therapeutic aspects of specific human genetic diseases as well as more global studies of the network interactions and consequences of the genes and proteins implicated in human disease.

    In the past, our lab has focused primarily on rare monogenic disorders including inborn errors of amino acid metabolism as well as various human retinal degenerations. For example, we have conducted extensive molecular, biochemical and structural studies of the enzymes of proline and ornithine metabolism defining the biochemical and molecular bases of several. Most notably, we showed that deficiency of ornithine-delta-aminotransferase (OAT) causes a blinding, chorioretinal degeneration known as gyrate atrophy of the choroid and retina (GA). We also produced a knockout mouse deficient in OAT, showed that it develops a retinal degeneration and used this model to develop and validate treatments. Similarly, we are interested in inborn errors of biogenesis and function of the peroxisome, a ubiquitous sub-cellular organelle whose protein components participate in numerous metabolic pathways. Using a variety of strategies, we identified the genes responsible for several (>10) genetic disorders of peroxisomal biogenesis (e.g. Zellweger syndrome). We also have a special interest in peroxisomal ABC transporters and have produced knockout mice for the genes encoding some of these to elucidate the function of these transporters and their role in human genetic disease.

    Recently, we have focused most of our efforts on understanding the genetic contribution to neuropsychiatric disease, especially schizophrenia. Working together with our collaborators Ann Pulver, Dimitri Avramopoulos and Gerry Nestadt, we have utilized a variety of whole genome approaches to search for genetic variants contributing risk for these disorders. Currently we are performing extensive studies of the genes in 10q22-23 and 8p21; we have found both linkage and association evidence for one or more schizophrenia susceptibility genes in both these regions. Our studies include extensive high throughput genotyping and sequencing, functional evaluation of coding variants and variants in candidate regulatory sequences and development and characterization of mouse models for the strongest candidates. The overall all goals of these studies are to identify the genes and the causative variants contributing risk and to use this information to identify key biological systems involved in the causation and pathophysiology of these disorders. We will use this information to search for additional risk genes and environmental variables as well as for the rational development of therapies.

    Selected Publications View all on PubMed

    1. Microdeletions of 3q29 confer high risk for schizophrenia., Mulle, Jennifer Gladys, Dodd Anne F., McGrath John A., Wolyniec Paula S., Mitchell Adele A., Shetty Amol C., Sobreira Nara L. M., Valle D, M Rudd Katharine, Satten Glen, et al., Am J Hum Genet, 2010 Aug 13, Volume 87, Issue 2, p.229-36, (2010)

    2. Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism., Mejias, Rebeca, Adamczyk A, Anggono Victor, Niranjan Tejasvi, Thomas Gareth M., Sharma Kamal, Skinner Cindy, Schwartz Charles E., Stevenson Roger E., M Fallin Daniele, et al., Proceedings of the National Academy of Sciences of the United States of America, 2011 Mar 22, Volume 108, Issue 12, p.4920-5, (2011)

    3. Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene., Sobreira, Nara L. M., Cirulli Elizabeth T., Avramopoulos Dimitrios, Wohler Elizabeth, Oswald Gretchen L., Stevens Eric L., Ge Dongliang, Shianna Kevin V., Smith Jason P.,Maia Jessica M., et al., PLoS Genet, 2010 Jun, Volume 6, Issue 6, p.e1000991, (2010)

    4. Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia., Chen, Pei-Lung, Avramopoulos D, Lasseter Virginia K., McGrath John A., M Fallin Daniele, Liang Kung-Yee, Nestadt G, Feng Ningping, Steel Gary, Cutting Andrew S., et al., American journal of human genetics, 2009 Jan, Volume 84, Issue 1, p.21-34, (2009)

    5. PRODH variants and risk for schizophrenia.,Willis, Alecia, Bender Hans Uli, Steel Gary, and Valle D, Amino acids, 2008 Nov, Volume 35, Issue 4, p.673-9, (2008)

    6. DNA methylation regulates MicroRNA expression.,Han, Liangfeng, P Witmer Dane, Casey Emily, Valle D, and Sukumar Saraswati, Cancer biology & therapy, 2007 Aug, Volume 6, Issue 8, p.1284-8, (2007)

    7. X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation.,Zhang, Lilei, Jie Chunfa, Obie Cassandra, Abidi Fatima, Schwartz Charles E., Stevenson Roger E., Valle D, and Wang Tao, Genome research, 2007 May, Volume 17, Issue 5, p.641-8, (2007)

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Memberships

    • American Association for the Advancement of Science
      Fellow
    • American College of Medical Genetics 
    • American Federation for Clinical Research
    • American Pediatrics Society
    • American Society of Clinical Investigation 
    • American Society of Human Genetics 
      Past president
    • European Society of Human Genetics 
    • Genetics Society of America
    • Human Genome Organization 
    • Institute of Medicine of the National Academy of Sciences
    • Large Scale Sequencing Advisory Committee, NHGRI
    • Large Scale Sequencing Committee, NHGRI
    • Society for Inherited Metabolic Disorders 
    • Society for Pediatric Research 
    • Society for the Study of Inborn Errors of Metabolism 
  • Videos & Media +
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