Skip Navigation
Find a Doctor
 
 
 
 

 

Photo of Dr. Harry Dietz

Harry C Dietz, MD

Co-Director, Medical Genetics Fellowship Training Program
Professor of Pediatrics

See Research on Pubmed | See Research on Google Scholar

Male
Appointment Phone

410-955-3071

Main Location

The Johns Hopkins Hospital

View All Locations
Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Co-Director, Medical Genetics Fellowship Training Program
  • Associate Director, Human Genetics Graduate Training Program
  • Director, William S. Smilow Center for Marfan Syndrome Research Institute of Genetic Medicine
  • Investigator, Howard Hughes Medical Institute
  • Victor A. McKusick Professor of Medicine and Genetics
  • Professor of Pediatrics
  • Associate Professor of Medicine
  • Assistant Professor of Neurological Surgery

Centers & Institutes

  • Children's Center
  • Comprehensive Marfan Center
  • Dana & Albert "Cubby" Broccoli Center for Aortic Diseases
  • Heart and Vascular Institute
  • Helen B. Taussig Children's Congenital Heart Center
  • Howard Hughes Medical Institute
  • Inherited Heart Disease, Center for
  • McKusick-Nathans Institute of Genetic Medicine

Expertise

Aortic Aneurysms, Marfan Syndrome, Medical Genetics, Pediatric Cardiology

Research Interests

Nonsense-mediated mRNA decay; Genetics of aging; Molecular basis of inherited disorders of vascular development and homeostasis; Pathogenesis of Marfan syndrome

Biography

Recognized as the world’s authority on Marfan syndrome, Dr. Harry Dietz conducted genomic mapping and research on therapeutic agents for deficiencies in the genetic protein fibrillin, which is linked to Marfan syndrome.

Dr. Dietz is a professor of pediatric cardiology, as well as a Victor A. McKusick Professor of Genetics in the departments of Medicine, Pediatrics and Molecular Biology and Genetics at the Johns Hopkins University School of Medicine.
He also serves as director of the William S. Smilow Center for Marfan Syndrome Research.
He has received more than 50 national and international awards and honors, including the Antoine Marfan Award from the National Marfan Foundation and the Art of Listening award from the American Heart Association.

Dr. Dietz is an ad hoc reviewer for 19 different organizations, including the American Journal of Cardiology, the Archives of Pediatric and Adolescent Medicine and the Journal of Clinical Investigation.
Over more than two decades, Dr. Dietz has mentored approximately 50 predoctoral and postdoctoral researchers. He has authored 213 original publications in peer-reviewed journals, 22 textbook chapters and 226 abstracts, and has also delivered more than 350 lectures on Marfan syndrome and related genetic disorders.

Dr. Dietz holds a bachelor’s degree from Duke University and a medical degree from SUNY Upstate Medical University. He completed a pediatric residency and a cardiology fellowship at Johns Hopkins University before joining the Johns Hopkins faculty in 1992. He is also board-certified by the American Board of Pediatrics.

Languages

  • English

Additional Resources

Additional Resources +
  • Education +

    Training

    • SUNY Upstate Medical University (Syracuse NY ) (1984)

    Residencies

    • Johns Hopkins University School of Medicine / Pediatrics (Baltimore MD ) (1989)

    Fellowships

    • Johns Hopkins University School of Medicine / Pediatrics (Baltimore MD ) (1992)
  • Research & Publications +

    Research Summary

    Our laboratory is interested in the development and homeostasis of the arterial wall. One goal is to understand genetic factors that predispose to aortic aneurysm, a condition accounting for 1-2 percent of deaths in industrialized countries. Our initial approach has been to study Marfan syndrome (MFS), a genetic disease that includes aortic aneurysm as part of the condition and that is caused by mutations in a single gene. It is anticipated that a comprehensive understanding of the cause, progression, and modulation of MFS will promote a greater understanding of vascular wall biology. Other vascular disorders currently being studied include: familial tetralogy of Fallot, cerebral cavernous malformation, a novel dominant syndrome of premature aging that prominently includes the cardiovascular system, the association of bicuspid aortic valve with aneurysm, and a novel and aggressive aneurysm phenotype called Loeys-Dietz syndrome. During our study of MFS, we recognized that a particular type of mutation is associated with very low levels of mutant RNA and tends to cause very mild forms of the disease. A second major interest of our laboratory is to understand the mechanism of nonsense-mediated mRNA decay; to evaluate its basic biologic purpose; and to assess its role as a potent modulator of disease severity in a wide variety of genetic disorders.

    Selected Publications View all on PubMed

    “New Insights Regarding the Pathogenesis and Modification of Marfan Syndrome and Related Disorders”, 78th Annual Scientific Meeting of the Japanese Circulation Society, Tokyo, Japan, March 2014.

    “Found in Translation: New Insights into the Pathogenesis and Treatment of Marfan Syndrome and Related Disorders”, Charles R. Ross Memorial, Student Research Celebration, Upstate Medical University, Syracuse, NY, April 2014.

    “The Extracellular Matrix in Homeostatic, Autoimmune and Fibrotic Disease Process", Christian J. 2014 Lambertsen Honorary Lecture, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, April 2014.

     “The Extracellular Matrix in Homeostatic, Autoimmune and Fibrotic Disease Processes”, Robert Berliner Professorship, Yale University, New Haven, CT, April 2014.

    “Found in Translation: New Insights into the Pathogenesis and Treatment of Marfan Syndrome and Related Disorders. American Heart Association, BCVS Meeting (Basic Cardiovascular Sciences), Las Vegas, NV, July, 2014

     “Marfan & Loeys-Dietz”, 5th Annual New England Symposium on Marfan Sydrome & Related Disorders. Ambrey Genetics, Marfan Foundation, MA Chapter and the NH/VT Network of the Marfan Foundation, Manchester, NH, September 2014.

    “Conditional Provocations in a Knock-In-Mouse Model of Marfan Syndrome” (Basic Science Session), “ New Therapeutic Opportunities in MFS and LDS as Revealed by Modifier Studies in Patients and Mouse Models” (Mechanisms and Options for Therapeutic Interventions Session), 9th International Research Symposium on Marfan Syndrome and Related Disorders, The Marfan Foundation, Paris (France), September 2014.

    “Found in Translation: New Insights into the Pathogenesis and Treatment of Marfan Syndrome and Related Disorders. Centro de Biología Molecular “Severo Ochoa”
    Consejo Superior de Investigaciones Científicas Madrid, Spain, October 2014.

    “Found in Translation: New Insights into the Pathogenesis and Treatment of Marfan Syndrome and Related Disorders”. Stevenson Lecture, University of Western Ontario, London, Ontario, November 2014.

     “Found in Translation: New Insights into the Pathogenesis and Treatment of Marfan Syndrome and Related Disorders”. Laennec Clinician/Educator Lecture, American Heart Association Scientific Sessions, Chicago, IL, November 2014.

    “The Extracellular Matrix in Homeostatic, Autoimmune and Fibrotic Disease”. Northwestern Lectures in Life Sciences, Northwestern University, Chicago, IL, January 2015.

     “Personalized Surgery – Genomics and Immunotherapy for Surgical Diseases” (SUS Presidential Session), 10th Academic Surgical Congress, Las Vegas, NV. February, 2015

  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Preceptor, Predoctoral Research Training Programs

    • Human Genetics
    • Biochemistry, Cellular & Molecular Biology
    • Cellular and Molecular Medicine

    Fellowship Training

    • Division of Pediatric Cardiology
    • Division of Pulmonary and Critical Care Medicine
    • Department of Surgery

    Courses and Syllabi

    Molecules & Cells Course Lecturer

    • Mutation in Human Disease
    • Marfan Syndrome, Clinical Correlations
  • Activities & Honors +

    Honors

    SUNY Upstate School of Medicine:

    • 1983 Alpha Omega Alpha
    • 1984 Summa Cum Laude, Valedictorian, Class of 1984

    The Johns Hopkins Hospital:

    • 1988 Pediatric Chief Resident
    • 1990 Harriet Lane Research Fellowship, Department of Pediatrics
    • 1992 First Richard Starr Ross Research Scholar, Johns Hopkins Medical Institutions
    • 2000 Director, William S. Smilow Center for Marfan Syndrome Research
    • 2004 First Victor A. McKusick Professor of Medicine and Genetic

    National and International:

    • 1992 Richard D. Rowe Award, Society for Pediatric Research
    • 1993 Young Investigator Award, Society for Pediatric Research
    • 1993 Patrick John Niland Memorial Lecture, University of Michigan
    • 1993 Professional Advisory Board, National Marfan Foundation
    • 1993 Editorial Board, Genomics
    • 1994 Antoine Marfan Award, National Marfan Foundation
    • 1995 Visiting Professorship, Northwestern University School of Medicine
    • 1996 Visiting Professorship, Cleveland Clinic
    • 1997 Appointed to the Howard Hughes Medical Institute
    • 1997 Elster Memorial Lecture, Mount Sinai University School of Medicine
    • 1997 Visiting Professorship and Memorial Lecture, Hospital for Sick Children
    • 1997 Visiting Professorship, Winner Memorial Lecture, Univ of Maryland School of Medicine
    • 1997 Department of Energy BER 50th Anniversary Celebration, National Academy of Sciences
    • 1997 Editorial Board, Human Molecular Genetics
    • 1998 Chair, Professional Advisory Board, National Marfan Foundation
    • 1999 Editorial Board, Circulation Research
    • 2001 Pauline Wilson Horner Lecture, Case Western Reserve University
    • 2001 Editorial Board, Pediatric Research
    • 2002 Inductee, Society for Pediatric Research
    • 2002 Chair, Agarini Foundation Scientific Committee
    • 2002 Editorial Board, American Journal of Human Genetics
    • 2003 Inductee, American Society for Clinical Investigation
    • 2004 Board of Scientific Counselors, National Human Genome Research Institute
    • 2005 Elected to the Board of the American Society for Clinical Investigation
    • 2005 Inductee, American Association for the Advancement of Science
    • 2005 Wilson Lecture, Case Western Reserve University
    • 2005 Editorial Board, American Journal of Medical Genetics
    • 2006 Recipient of the Curt Stern Award, American Society of Human Genetics
    • 2006 Nahum J. Winer Memorial Lecture, New York Academy of Medicine
    • 2006 Thomas P. Graham Jr. Lecture, Pioneer Lecture Series, Vanderbilt University
    • 2006 Cazden Lecture, Oregon health Sciences University
    • 2006 Meinhard Robinow Lecture, Dayton Children's Hospital
    • 2007 Chair, Board of Scientific Counselors, National Human Genome Research 
    • Institute
    • 2007 Elected to the Board of the American Society of Human Genetics
    • 2007 Scientific Advisory Board, Center for Preterm Birth Research at Washington University in St. Louis
    • 2007 Princess Lilian Foundation Professorship, Gent, Belgium
    • 2007 Edmund R. McCluskey Memorial Lectureship, University of Pittsburgh
    • 2007 Paulette Shirley Pritchett Endowed Lecture in Pathology, University of Alabama at Birmingham
    • 2007 Isadore Rosenfeld Visiting Professorship, Weil Medical College of Cornell University
    • 2007 Robert M. Jeresaty Lecture, St. Francis Medical Center, Hartford
    • 2007 Congressional Biomedical Research Caucus Symposium, Joint Steering Committee on Public Policy
    • 2007 Whitehead Symposium XXV, Massachusetts Institute of Technology
    • 2007 Kathryn L. Ober Visiting Professor, Indiana University
    • 2007 Editorial Board, Clinical and Translational Science
    • 2008 Hero with a Heart Honoree, National Marfan Foundation 
    • 2008 Humanitarian Award, American Skin Association, New York
    • 2008 Inductee, National Academy of Sciences Institute of Medicine
    • 2009 Heritage Award, Johns Hopkins University
    • 2009 George E. Brown Memorial Lecturer Award – American Heart Association
    • 2010 Niccolo Paganini Prize, SIMA Congreso Internacional de Síndrome de Marfan
    • 2010 Art of Listening Award, Genetic Alliance
    • 2011 Pruzansky Lecture (Annual Clinical Genetics Meeting) - ACMG
    • 2011 Inductee, The National Academy of Sciences
    • 2012 Colonel Harland Sanders Lifetime Achievement Award in Medical Genetics,
    • March of Dimes and American College of Medical Genetics
    • 2012 Winner - Taubman Prize for Excellence in Translation Medical Science
    • 2013 Inductee – Association of American Physician
    • 2013 Winner – Pasarow Award in Cardiovascular Research
    • 2014 Winner – InBev - Baillet Latour Health Prize, Belgium
    • 2014 Winner – Harrington Prize from the American Society for Clinical Investigation and the Harrington Institute
    • 2014 Clinical Cardiology Laennec Clinician/Educator Lecture Award

    Professional Activities

    • Director of the Professional Advisory Board, National Marfan Foundation
    • Howard Hughes Medical Institute
    • Board of Governors, National Human Genome Research Institute
    • American Society for Pediatric Research
    • Editorial Boards: Genomics; American Journal of Medical Genetics; Human Molecular Genetics; Pediatric Research; Circulation Research; American Journal of Human Genetics; Clinical and Translational Science; eLife; Science Translation Medicine
    • Heart Disease in the Young, American Heart Association Study Section (1996-1999)
    • Professional Advisory Board of the National Marfan Foundation (1997 – present)
    • Induced Mutant Repository Advisory Board, Jackson Laboratories 
    • Member, Young Investigator's Day Award Review Committee
    • Member, David Israel Macht Memorial Research Prize Committee
    • Member, Michael A. Sarnoff Research Award Committee
    • Member, Human Genetics Selection Committee
    • Member, Medical Scientist Training Program Steering Committee (M.D./Ph.D.)
    • Associate Director, Human Genetics Predoctoral Training Program 
    • American Society of Human Genetics Nomination Committee, 1999
    • The Genome Action Coalition (American Society of Human Genetics Representative)
    • Member, McKusick-Nathans Institute of Genetic Medicine Directorship Search Committee, 
    • 1999-2000
    • Member, Agarini Foundation Scientific Committee
    • Member, McKusick-Nathans Institute of Genetic Medicine Recruitment Committee
    • Member, Evaluation Committee for Specialized Centers of Research (SCOR) Program in 
    • Cardiovascular Disease, National Institutes of Health, Division of Heart and Vascular Diseases 
    • Member, Mammalian Genetics Study Section, National Institutes of Health (2002-2004)
    • Member, Department of Molecular Biology and Genetics Chairman Recruitment Committee
    • Chair, Board of Scientific Counselors, National Human Genome Research Institute
    • Member, Advisory Board of the Gene Vector Core
    • Member, Board of American Society for Clinical Investigation
    • Director, William S. Smilow Center for Marfan Syndrome Research
    • Member, Professional Advisory Board of the Ehlers-Danlos Syndrome National Foundation
    • Member, Institute of Medicine (IOM) Committee on Accelerating Research and Development for Rare 
    • Diseases and Orphan Products 
    • Chair, National of Arthritis and Musculoskeletal and Skin Diseases Advisory Council of the National
    • Institutes of Health (NIAMS) 3/2010 – 9/2013 
    • Member, Global Fibrosis Foundation Medical Advisory Council
    • Editor, Science Translation Medicine
    • ASHG Nominating Committee
    • Musculoskeletal P & F Advisory Board
    • The Research Committee of the Cincinnati Medical Center Board of Trustees
    • Director, William S. Smilow Center for Marfan Syndrome Research
    • Member, Search and Screen Committee, Medical Physiology and Metabolism Section, 
    • National Academy of Sciences
    • Member, National Organization for Rare Disorders (NORD) Scientific Advisory Committee
    • President, The American Society of Human Genetics
    • The American Society of Human Genetics
    • Fellow of the American Heart Association
    • Charter Fellow of the Council on Basic Cardiovascular Sciences
    • Society for Pediatric Research
    • American Society for Clinical Investigation
    • Fellow of the American Association for the Advancement of Science
    • Institute of Medicine, National Academies of Science
    • National Academy of Sciences
    • Association of American Physicians (AAP)

    Ad Hoc Reviewer:

    • American Journal of Cardiology 
    • American Journal of Human Genetics 
    • American Journal of Medical Genetics 
    • Archives of Pediatric and Adolescent Medicine 
    • Cell
    • Circulation 
    • Clinical Genetics 
    • Developmental Dynamics 
    • European Journal of Human Genetics
    • Human Molecular Genetics
    • Human Mutation 
    • Journal of Clinical Investigation 
    • Nature Genetics 
    • Nature Medicine 
    • New England Journal of Medicine 
    • Nucleic Acids Research 
    • Proceedings of the National Academy of Sciences (USA) 
    • RNA 
    • Science

     

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-614-0701
    Appointment Phone: 410-955-3071
    Fax: 410-614-9246
    Location Map

    Department/Division

    • Pediatrics - Cardiology

Is This You? Edit Profile

 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.