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Garry R Cutting, M.D.

Photo of Dr. Garry R Cutting, M.D.

Aetna/U.S. Healthcare Professor of Medical Genetics

Professor of Pediatrics

Male

Expertise: Cystic Fibrosis, Genetics, Medical Genetics

Research Interests: Cystic fibrosis; Determining CFTR genotype in phenotypes that overlap with cystic fibrosis (atypical CF, chronic sinusitis, male infertility and obstructive lung diseases); Identifying genetic variants that contribute to chronic lung disease by linkage and candidate gene approaches; Determining the biological role of the CFTR protein by identifying mutations in patients with CF characterization of CFTR transcripts and protein from patients of various genotypes and analysis of chloride conduction properties of mutated CFTR expressed in various cell types; Structure/function analysis of chloride channels expressed in epithelial tissues and retinal neurons ...read more

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Locations

Broadway Research Building
Appointment Phone: 410-955-3071

733 N. Broadway
Suite 551
Baltimore, MD 21287 map

The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-502-1033

1800 Orleans St.
Baltimore, MD 21287 map

Background

Dr. Garry R. Cutting is a professor of pediatrics at the Johns Hopkins University School of Medicine.  He is the Aetna/U.S. Healthcare Professor of Medical Genetics at Johns Hopkins and is also a faculty member of the McKusick-Nathans Institute of Genetic Medicine. His areas of clinical expertise include cystic fibrosis and medical genetics. 

Dr. Cutting’s primary research interest is in the molecular genetics of cystic fibrosis and, more recently, elucidating modifier genes underlying variation in the severity of cystic fibrosis. He is also the director of the CFTR2 project, a worldwide collection of genotype and phenotype data on over 40,000 patients with cystic fibrosis. 

After receiving his undergraduate degree in biology from the University of Connecticut, Dr. Cutting earned his medical degree from the University of Connecticut School of Medicine. He completed his residency training in pediatrics and a fellowship in medical genetics at the Johns Hopkins University School of Medicine and has remained at Johns Hopkins for his entire professional career. 

Dr. Cutting is the recipient of the Paul di Sant’Agnese Distinguished Scientific Achievement Award from the Cystic Fibrosis Foundation and a MERIT award from the National Institutes of Health. He has published more than 150 peer-reviewed articles. He is director of the postdoctoral clinical genetics fellowship programs, the DNA Diagnostic Laboratory and the Genetic Translational Technology Core at Johns Hopkins. 

...read more

Titles

  • Aetna/U.S. Healthcare Professor of Medical Genetics
  • Director, Postdoctoral Clinical Genetics Fellowship Programs
  • Preceptor, Predoctoral Training Program in Human Genetics
  • Director, DNA Diagnostic Laboratory
  • Director, Genetic Translational Technology Core
  • Director, Medical Genetics Training Program
  • Professor of Pediatrics

Departments / Divisions

Education

Degrees

  • MD, University of Connecticut Health Center (1983)

Board Certifications

  • American Board of Medical Genetics and Genomics / Clinical Biochemical Genetics (1990)
  • American Board of Medical Genetics and Genomics / Clinical Genetics / MD (1990)
  • American Board of Medical Genetics and Genomics / Clinical Molecular Genetics (1990)
  • American Board of Pediatrics / Pediatrics (1987)

Research & Publications

Research Summary

Dr. Cutting’s primary research interest is in the molecular genetics of cystic fibrosis and, more recently, elucidating modifier genes underlying variation in the severity of cystic fibrosis. His recent research uncovered 105 genetic errors that cause cystic fibrosis and the genes that cause cystic fibrosis-related intestinal obstruction in newborns.

Core Facility: Genetics Translational Technology Core

Selected Publications

View all on Pubmed

Masica DL, Sosnay PR, Raraigh KS, Cutting GR, Karchin R. "Missense variants in CFTR nucleotide-binding domains predict quantitative phenotypes associated with cystic fibrosis disease severity." Hum Mol Genet. 2014 Dec 8. pii: ddu607. [Epub ahead of print]

Cutting GR. "Cystic fibrosis genetics: from molecular understanding to clinical application." Nat Rev Genet. 2015 Jan;16(1):45-56. doi: 10.1038/nrg3849. Epub 2014 Nov 18.

Collaco JM, Blackman SM, Raraigh KS, Morrow CB, Cutting GR, Paranjape SM. "Self-reported exercise and longitudinal outcomes in cystic fibrosis: a retrospective cohort study." BMC Pulm Med. 2014 Oct 6;14:159. doi: 10.1186/1471-2466-14-159.

Hampton TH, Green DM, Cutting GR, Morrison HG, Sogin ML, Gifford AH, Stanton BA, O'Toole GA. "The microbiome in pediatric cystic fibrosis patients: the role of shared environment suggests a window of intervention." Microbiome. 2014 Apr 28;2:14. doi: 10.1186/2049-2618-2-14. eCollection 2014.

Sharma N, Sosnay PR, Ramalho AS, Douville C, Franca A, Gottschalk LB, Park J, Lee M, Vecchio-Pagan B, Raraigh KS, Amaral MD, Karchin R, Cutting GR. "Experimental assessment of splicing variants using expression minigenes and comparison with in silico predictions." Hum Mutat. 2014 Oct;35(10):1249-59. doi: 10.1002/humu.22624. Epub 2014 Sep 10.

Zeitlin PL, Lu L, Hwang TC, Rhim J, Craig R, Cutting GR, Stetten G, Kieffer KA, Guggino WB. A Cystic Fibrosis bronchial epithelial cell line: Immortalization by Adeno-12 SV-40 infection. Am J Resp Cell and Mol Biol (1991), 4:313-319.

McColley SA, Rosenstein BJ, Cutting GR. Differences in Expression of Cystic Fibrosis in Blacks and Whites. Am J Dis Child (1991), 145:94-97.

Nunes V, Gaona MC, Mana P, Casals T, Cutting GR, Estivill X: Prenatal diagnosis of cystic fibrosis by simultaneous analysis of two different mutations. Prenatal Diagnosis (1991) 11:671-672.

Beaudet AL, Perciaccante RG, Cutting GR. Homozygous nonsense mutation causing cystic fibrosis with uniparental disomy. Am. J. Hum. Genet. (1991) 48:1213.

Cutting GR, Kasch LM, Rosenstein BJ, Zielensky J, Tsui L-C, Antonarakis SE, Kazazian H Jr. A cluster of Cystic Fibrosis mutations in the first nucleotide binding fold domain of the Cystic Fibrosis conductance regulator protein. Nature (1990), 346:366-369.

Cutting GR, Kasch LM, Rosenstein BJ, Tsui L-C, Kazazian H and Antonarakis SE. Two patients with Cystic Fibrosis, nonsense mutations in each Cystic Fibrosis gene, and mild pulmonary disease. New Engl J Med (1990), 323:1685-1689.

Cutting GR, Kasch LM. Worldwide survey of the deltaF508 mutation-report from the Cystic Fibrosis Genetic Analysis Consortium. Am J Hum Genet (1990), 47:354-359.

Cutting GR, McGinniss MJ, Kasch LM, Tsipouras P, Antonarakis SE. Physical mapping by PFGE localizes the COL3A1 and COL5A2 genes to a 35kb region on chromosome 2. Genomics (1990), 8:407-410.

Cutting GR, Antonarakis SE, Beutow KH, Kasch LM, Rosenstein BJ, Kazazian H Jr. Analysis of DNA polymorphism haplotypes linked to the Cystic Fibrosis locus in North American Black and Caucasian families support the existence of multiple mutations of the Cystic Fibrosis gene. Am J Hum Genet (1989), 44:307-318.

Jabs EW, Goble CA, Cutting GR. The macromolecular organization of human centromeric region reveals high frequency, polymorphic macro-DNA repeats. Proc Natl Acad Sci (USA) (1989), 86:202-206.

Cutting GR, Kazazian H Jr, Antonarakis SE, Killen PD, Yamada Y and Francomano CA. Macrorestriction mapping of human collagen genes COL4A1 and COL4A2 on chromosome 13q34. Genomics (1988), 3:256-263.

Cutting GR, Antonarakis SE, Youssoufian H and Kazazian H Jr. The accuracy and limitations of Pulsed Field Gel Electrophoresis in sizing partial deletions of the factor VIII gene. Molecular Biology and Medicine (1988), 5:173-184.

Academic Affiliations & Courses

Courses and Syllabi

  • Introduction to Pathobiology
  • Analytical Methods in Clinical Medicine
  • Jackson Lab Course
  • Human Genetics Lecture Series
  • Advanced Topics in Human Genetics
  • Molecular Mechanisms
  • Cellular and Molecular Medicine
  • Molecules and Cells Course

Activities & Honors

Honors

  • Paul di Sant’Agnese Distinguished Scientific Achievement Award, Cystic Fibrosis Foundation
  • MERIT Award, National Institutes of Health
  • Merck Clinician Scientist Award
  • Linda Ives Award, Basic Science Research in Pediatrics

Memberships

  • Faculty Advancement Committee
  • Human Genetics Committee
  • U.S. Cystic Fibrosis Foundation

Professional Activities

  • Director, CFTR2 project
  • Director, Clinical Genetics Laboratory Training Programs
  • Preceptor, Predoctoral Training Program in Human Genetics
  • Director, DNA Diagnostic Laboratory
  • Director, Genetic Translational Technology Core

Videos & Media

Lectures and Presentations

  • Identification of Sequences Conferring Unique Properties to GABAC Receptors Formed of ? Subunits
    Symposium Presentation ,  Ft. Lauderdale
    Association for Research in Vision & Ophthalmology Annual Meeting
  • Genetic Aspects of Chronic Sinusitis
    Presentation , Scottsdale
    American Academy of Allergy Asthma & Immunology
  • Mutation Analysis in Cystic Fibrosis
    Symposium Presentation , Jerusalem
    XIIth International Cystic Fibrosis Congress
  • Implications of the Multiple Functions of CFTR and Therapy for CF and Gene Therapy for Cystic Fibrosis
    Symposium Presentations , Rio de Janeiro
    9th International Congress of Human Genetics
  • Consequences of CF Mutation Upon CFTR Functions
    Symposium Presentation , Lyon
    Conferences Philippe Laudat
  • Ethnic distribution and phenotypic consequences of CF mutations
    Bethesda
    NIH Consensus Conference: Genetic Testing for Cystic Fibrosis
  • Molecular composition of GABAC receptors
    Symposium Presentation , Fort Lauderdale
    First Annual Conference in Association with Vision Research: Molecular, Cellular and Genetic Approaches to Function and Dysfunction of the Retina
  • “Molecular biology and rhinosinusitis” and “New directions in gene therapy for rhinology”
    Presentations , Philadelphia
    Cottle International Rhinology Centennial Conference
  • Functional analysis of ClC-2 chloride channels stably expressed in cystic fibrosis airway cells
    Symposium Presentation , Kansas City
    Annual Meeting Biophysical Society
  • Phenotypes Associated with Dysfunction of the Cystic Fibrosis Transmembrane Conductance Regulator
    Conference presentation , Lisbon
    Departamento de Genetica Humana Instituto Nacional de Saude

Recent News Articles and Media Coverage

Genes Tied to Severity of Cystic Fibrosis Identified,” U.S. News & World Report, May 22, 2011

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