Dr. Montgomery is a co-principal investigator for an NIH/ITN sponsored tolerance clinical trial for simultaneous donor bone marrow and live donor kidney transplantation. He runs multiple investigator initiated clinical trials of novel desensitization therapies. His research interests include mechanisms underlying the immunomodulatory effect of plasmapheresis, stem cell therapy for highly sensitized patients, and gene and cell based therapies in transplantation.
ACCEPTOR Clinical Trial for Kidney Transplant Recipients
The purpose of this study is to find out if the study treatment will allow people to accept their new kidney and be able to stop taking anti-rejection medications.
Montgomery RA, Lonze BE, King KE, Kraus ES, Kucirka LM, Locke JE, Warren DS, Simpkins CE, Dagher NN, Singer AL, Zachary AA, Segev DL. Desensitization of HLA-Incompatible Kidney Recipients and Survival. N Engl J Med. 2011 July 28;365(4):318-326.
Rees MA, Kopke JE, Pelletier RP, Segev DL, Rutter ME, Fabrega AJ, Rogers J, Pankewycz OG, Hiller J, Roth AE, Sandholm T, Unver MU, Montgomery RA. A nonsimultaneous, extended, altruistic-donor chain. N Engl J Med. 2009 March 12;360(11):1096-1101.
Montgomery RA, Zachary AA, Ratner LE, Segev DL, Hiller JM, Houp J, Cooper M, Kavoussi L, Jarrett T, Burdick J, Maley WR, Melancon JK, Kozlowski T, Simpkins CE, Phillips M, Desai A, Collins V, Reeb B, Kraus E, Rabb H, Leffell MS, Warren DS. Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation. JAMA. 2005 Oct 5;294(13):1655-63.
Segev DL, Gentry SE, Warren DS, Reeb B, Montgomery RA. 2005. Kidney Paired Donation and Optimizing the Use of Live Donor Organs. JAMA 293(15):1883-90.
Montgomery RA, Gentry SE, Marks WH, Warren DS, Hiller J, Houp J, Zachary AA, Melancon JK, Maley WR, Rabb H, Simpkins C, Segev DL. Domino paired kidney donation: A strategy to make best use of live non-directed donation. Lancet. 2006 July 29;368(9533):419-421.
Segev DL, Muzaale AD, Caffo BS, Mehta SH, Singer AL, Taranto SE, McBride MA, Montgomery RA. Perioperative mortality and long-term survival following live kidney donation. JAMA. 2010 March 10;303(10):959-966.
Frischmeyer-Guerrerio PA*, Montgomery RA*, Warren DS, Cooke SK, Lutz J, Sonnenday CJ, Guerrerio AL, Dietz HC. Perturbation of Thymocyte Development in Nonsense Mediated Decay-Deficient Mice. PNAS 2011 June 28;108(26):10638-10643.* Equal Contributors.
Lonze BE, Singer AL, Montgomery RA. Eculizumab and renal transplantation in a patient with CAPS. N Engl J Med. 2010 May 6;362(18):1744-1745.
Alachkar N, Gupta G, Montgomery RA. Angiotensin antibodies and focal segmental glomerulosclerosis. N Engl J Med. 2013 Mar 7;368(10):971-3.
Kucirka LM, Grams ME, Lessler J, Hall EC, James N, Massie AB, Montgomery RA, Segev DL. Association of race and age with survival among patients undergoing dialysis. JAMA. 2011 August 10;306(6):620-626.
Muzaale AD, Massie AB, Wang MC, Montgomery RA, McBride MA, Wainright JL, Segev DL. Risk of end-stage renal disease following live kidney donation. JAMA. 2014 Feb 12;311(6):579-86.
Ratner LE, Kavoussi LR, Sroka M, Hiller J, Weber R, Schulam PG, Montgomery RA. Laparoscopic assisted live donor nephrectomy: a comparison with the open approach. Transplantation. 1997 63(2): 229-233.
Montgomery RA, Zachary AA, Racusen LL, Leffell MS, King KE, Burdick J, Maley WR, Ratner LE. Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into crossmatch-positive recipients. Transplantation 2000. 70(6): 887-895.