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Ralph Hruban, MD

Director of the Sol Goldman Pancreatic Cancer Research Center
Professor of Pathology
Male
Appointment Phone

410-955-2163

Main Location

The Johns Hopkins Hospital

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Titles

  • Director of the Sol Goldman Pancreatic Cancer Research Center
  • Interim Director, Department of Pathology
  • Director, Division of Gastrointestinal/Liver Pathology
  • Deputy Director, Research and Programs, Department of Pathology
  • President-elect, Johns Hopkins Medical and Surgical Association
  • Professor of Pathology
  • Professor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center
  • Sol Goldman Pancreatic Cancer Research Center

Expertise

Neuroendocrine Tumors, Pancreatic Cancer, Pathology

Research Interests

Pancreatic Cancer

Biography

Dr. Ralph Hruban is a professor of pathology and oncology at the Johns Hopkins University School of Medicine. A world-renowned pancreatic cancer pathology expert, his areas of clinical expertise include neuroendocrine tumors, pancreatic cancer and pathology.

His research contributions include the characterization of PanINs, the precursor lesions that give rise to invasive pancreatic cancer.

Dr. Hruban serves as director of the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins. He’s also the director of the Division of Gastrointestinal/Liver Pathology, as well as interim director and deputy director of research and programs in the Department of Pathology.

After receiving an undergraduate degree from the University of Chicago and a medical degree from Johns Hopkins, Dr. Hruban continued his residency training in anatomic pathology at Johns Hopkins. He then completed a fellowship in surgical pathology at Memorial Sloan-Kettering Cancer Center in New York and returned to join the faculty at Johns Hopkins in 1990.

Dr. Hruban co-founded the National Familial Pancreas Tumor Registry at Johns Hopkins in 1994, created an award-winning iPad application to teach pancreas pathology and produced an award-winning documentary on the life of William Stewart Halsted, Hopkins’ first surgeon-in-chief.

He has authored more than 600 peer-reviewed manuscripts and five books, including the standard textbook on pancreatic pathology (the AFIP Fascicle on Tumors of the Pancreas) and the World Health Organization “blue book” on tumors of the digestive tract. He is recognized by the Institute for Scientific Information as a highly cited researcher and by Essential Science Indicators as the most highly cited pancreatic cancer scientist.

Dr. Hruban has received numerous awards including the Arthur Purdy Stout Prize for significant career achievements in surgical pathology, the Ramzi Cotran Award from the United States and Canadian Academy of Pathology, the PanCAN Medical Visionary Award, the Ranice W. Crosby Distinguished Achievement Award in Art as Applied to Medicine, the Ruth C. Brufsky Award of Excellence in Clinical Research for Pancreatic Cancer, the Frank Netter Award for Special Contributions to Medical Education, the Johns Hopkins University Distinguished Alumni Award, the Team Science Award from the American Association for Cancer Research, and five teaching awards from the Johns Hopkins School of Medicine. He was elected to the German National Academy of Sciences Leopoldina in 2013.

Languages

  • English
Additional Resources +
  • Education +

    Training

    • Johns Hopkins University School of Medicine (Baltimore MD) (1985)

    Residencies

    • Johns Hopkins University School of Medicine / Pathology (Baltimore MD) (1990)

    Fellowships

    • Memorial Sloan - Kettering Cancer Center / Pathology (New York NY) (1989)

    Certifications

    • American Board of Pathology / Anatomic Pathology (1990)
  • Research & Publications +

    Research Summary

    The goals of Dr. Hruban’s research are to understand the noninvasive precursor lesions from which invasive pancreatic cancers develop (PanINs and IPMNs); why pancreatic cancer aggregates in some families; and the pathologic ramifications of genetic alterations in the pancreas. Toward these goals, Dr. Hruban has applied molecular genetics to the study of noninvasive precursor lesions in the pancreas and to patients with familial pancreatic cancer. A better understanding of these lesions and families may provide an avenue for the early detection of pancreatic cancer.

    Selected Publications

    1. Canto, M.I.; Goggins, M.; Hruban, R.H.; Petersen, G.M.; Giardiello, F.M.; Yeo, C.; Fishman, E.K.; Brune, K.; Axilbund, J.; Griffin, C.; Ali, S.; Richman, J.; Jagannath, S.; Kantsevoy, S.V.; Kalloo, A.N. Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study. Clin Gastroenterol Hepatol. 2006 Jun;4(6):766-781; quiz 665.
    2. Hansel, D.E.; Meeker, A.K.; Hicks, J.; De Marzo, A.M.; Lillemoe, K.D.; Schulick, R.; Hruban, R.H.; Maitra, A.; Argani, P. Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma. Mod Pathol. 2006 Jun;19(6):772-779.
    3. Jimeno, A.; Amador, M.L.; Kulesza, P.; Wang, X.; Rubio-Viqueira, B.; Zhang, X.; Chan, A.; Wheelhouse, J.; Kuramochi, H.; Tanaka, K.; Danenberg, K.; Messersmith, W.A.; Almuete, V.; Hruban, R.H.; Maitra, A.; Yeo, C.J.; Hidalgo, M. Assessment of celecoxib pharmacodynamics in pancreatic cancer. Mol Cancer Ther. 2006 Dec;5(12):3240-3247.
    4. Rubio-Viqueira, B.; Jimeno, A.; Cusatis, G.; Zhang, X.; Iacobuzio-Donahue, C.; Karikari, C.; Shi, C.; Danenberg, K.; Danenberg, P.V.; Kuramochi, H.; Tanaka, K.; Singh, S.; Salimi-Moosavi, H.; Bouraoud, N.; Amador, M.L.; Altiok, S.; Kulesza, P.; Yeo, C.; Messersmith, W.; Eshleman, J.; Hruban, R.H.; Maitra, A.; Hidalgo, M. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res. 2006 Aug 1;12(15):4652-4661.
    5. Foss, C.A.; Fox, J.J.; Feldmann, G.; Maitra, A.; Iacobuzio-Donohue, C.; Kern, S.E.; Hruban, R.; Pomper, M.G. Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of pancreatic cancer. Mol Imaging. 2007 Mar-Apr;6(2):131-139.
    6. Herman, J.M.; Swartz, M.J.; Hsu, C.C.; Winter, J.; Pawlik, T.M.; Sugar, E.; Robinson, R.; Laheru, D.A.; Jaffee, E.; Hruban, R.H.; Campbell, K.A.; Wolfgang, C.L.; Asrari, F.; Donehower, R.; Hidalgo, M.; Diaz, L.A., Jr.; Yeo, C.; Cameron, J.L.; Schulick, R.D.; Abrams, R. Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital. J Clin Oncol. 2008 Jul 20;26(21):3503-3510.
    7. Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Angenendt, P.; Mankoo, P.; Carter, H.; Kamiyama, H.; Jimeno, A.; Hong, S.M.; Fu, B.; Lin, M.T.; Calhoun, E.S.; Kamiyama, M.; Walter, K.; Nikolskaya, T.; Nikolsky, Y.; Hartigan, J.; Smith, D.R.; Hidalgo, M.; Leach, S.D.; Klein, A.P.; Jaffee, E.M.; Goggins, M.; Maitra, A.; Iacobuzio-Donahue, C.; Eshleman, J.R.; Kern, S.E.; Hruban, R.H.; Karchin, R.; Papadopoulos, N.; Parmigiani, G.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26;321(5897):1801-1806.
    8. Park, S.W.; Davison, J.M.; Rhee, J.; Hruban, R.H.; Maitra, A.; Leach, S.D. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology. 2008 Jun;134(7):2080-2090.
    9. Winter, J.M.; Ting, A.H.; Vilardell, F.; Gallmeier, E.; Baylin, S.B.; Hruban, R.H.; Kern, S.E.; Iacobuzio-Donahue, C.A. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res. 2008 Jan 15;14(2):412-418.
    10. Axilbund, J.E.; Argani, P.; Kamiyama, M.; Palmisano, E.; Raben, M.; Borges, M.; Brune, K.A.; Goggins, M.; Hruban, R.H.; Klein, A.P. Absence of germline BRCA1 mutations in familial pancreatic cancer patients. Cancer Biol Ther. 2009 Jan;8(2):131-135.
    11. Blackford, A.; Parmigiani, G.; Kensler, T.W.; Wolfgang, C.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Klein, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W.; Hruban, R.H. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15;69(8):3681-3688.
    12. Blackford, A.; Serrano, O.K.; Wolfgang, C.L.; Parmigiani, G.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Herman, J.M.; Laheru, D.; Klein, A.P.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Hruban, R.H. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009 Jul 15;15(14):4674-4679.
    13. Harsha, H.C.; Kandasamy, K.; Ranganathan, P.; Rani, S.; Ramabadran, S.; Gollapudi, S.; Balakrishnan, L.; Dwivedi, S.B.; Telikicherla, D.; Selvan, L.D.; Goel, R.; Mathivanan, S.; Marimuthu, A.; Kashyap, M.; Vizza, R.F.; Mayer, R.J.; Decaprio, J.A.; Srivastava, S.; Hanash, S.M.; Hruban, R.H.; Pandey, A. A compendium of potential biomarkers of pancreatic cancer. PLoS Med. 2009 Apr 7;6(4):e1000046.
    14. Jones, S.; Hruban, R.H.; Kamiyama, M.; Borges, M.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Palmisano, E.; Brune, K.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Parmigiani, G.; Kern, S.E.; Velculescu, V.E.; Kinzler, K.W.; Vogelstein, B.; Eshleman, J.R.; Goggins, M.; Klein, A.P. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009 Apr 10;324(5924):217.
    15. Koorstra, J.B.; Hong, S.M.; Shi, C.; Meeker, A.K.; Ryu, J.K.; Offerhaus, G.J.; Goggins, M.G.; Hruban, R.H.; Maitra, A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod Pathol. 2009 Nov;22(11):1439-1445.
    16. Reddy, S.; Cameron, J.L.; Scudiere, J.; Hruban, R.H.; Fishman, E.K.; Ahuja, N.; Pawlik, T.M.; Edil, B.H.; Schulick, R.D.; Wolfgang, C.L. Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series. J Am Coll Surg. 2009 May;208(5):950-957; discussion 957-959.
    17. Wang, L.; Brune, K.A.; Visvanathan, K.; Laheru, D.; Herman, J.; Wolfgang, C.; Schulick, R.; Cameron, J.L.; Goggins, M.; Hruban, R.H.; Klein, A.P. Elevated cancer mortality in the relatives of patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2829-2834.
    18. Brune, K.A.; Lau, B.; Palmisano, E.; Canto, M.; Goggins, M.G.; Hruban, R.H.; Klein, A.P. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst. 2010 Jan 20;102(2):119-126.
    19. Cunningham, S.C.; Hruban, R.H.; Schulick, R.D. Differentiating intraductal papillary mucinous neoplasms from other pancreatic cystic lesions. World J Gastrointest Surg. 2010 Oct 27;2(10):331-336.
    20. Gold, D.V.; Goggins, M.; Modrak, D.E.; Newsome, G.; Liu, M.; Shi, C.; Hruban, R.H.; Goldenberg, D.M. Detection of early-stage pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2786-2794.
    21. Hong, S.M.; Heaphy, C.M.; Shi, C.; Eo, S.H.; Cho, H.; Meeker, A.K.; Eshleman, J.R.; Hruban, R.H.; Goggins, M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod Pathol. 2010 Sep 24.
    22. Hristov, B.; Reddy, S.; Lin, S.H.; Cameron, J.L.; Pawlik, T.M.; Hruban, R.H.; Swartz, M.J.; Edil, B.H.; Kemp, C.; Wolfgang, C.L.; Herman, J.M. Outcomes of adjuvant chemoradiation after pancreaticoduodenectomy with mesenterico-portal vein resection for adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):176-180.
    23. Hruban, R.H.; Canto, M.I.; Goggins, M.; Schulick, R.; Klein, A.P. Update on familial pancreatic cancer. Adv Surg. 2010;44:293-311.
    24. Kamiyama, H.; Kamiyama, M.; Hong, S.M.; Karikari, C.A.; Lin, M.T.; Borges, M.W.; Griffith, M.; Young, A.; Norris-Kirby, A.; Lubek, C.; Mizuma, M.; Feldmann, G.; Shi, C.; Liang, H.; Goggins, M.G.; Maitra, A.; Hruban, R.H.; Eshleman, J.R. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab Invest. 2010 May;90(5):665-673.
    25. Khashab, M.A.; Yong, E.; Lennon, A.M.; Shin, E.J.; Amateau, S.; Hruban, R.H.; Olino, K.; Giday, S.; Fishman, E.K.; Wolfgang, C.L.; Edil, B.H.; Makary, M.; Cantoy, M.I. EUS is still superior to multidetector computerized tomography for detection of pancreatic neuroendocrine tumors. Gastrointest Endosc. 2010 Nov 8.
    26. Lennon, A.M.; Newman, N.; Makary, M.A.; Edil, B.H.; Shin, E.J.; Khashab, M.A.; Hruban, R.H.; Wolfgang, C.L.; Schulick, R.D.; Giday, S.; Canto, M.I. EUS-guided tattooing before laparoscopic distal pancreatic resection (with video). Gastrointest Endosc. 2010 Nov;72(5):1089-1094.
    27. Liby, K.T.; Royce, D.B.; Risingsong, R.; Williams, C.R.; Maitra, A.; Hruban, R.H.; Sporn, M.B. Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer. Cancer Prev Res (Phila). 2010 Nov;3(11):1427-1434.
    28. Park, J.Y.; S-M., H.; Klimstra, D.S.; Goggins, M.G.; Maitra, A.; Hruban, R.H. Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms. Applied Immunohistochemistry & Molecular Morphology. 2010;In Press.
    29. Poultsides, G.A.; Reddy, S.; Cameron, J.L.; Hruban, R.H.; Pawlik, T.M.; Ahuja, N.; Jain, A.; Edil, B.H.; Iacobuzio-Donahue, C.A.; Schulick, R.D.; Wolfgang, C.L. Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas. Ann Surg. 2010 Mar;251(3):470-476.
    30. Redmond, K.J.; Wolfgang, C.L.; Sugar, E.A.; Ahn, J.; Nathan, H.; Laheru, D.; Edil, B.H.; Choti, M.A.; Pawlik, T.M.; Hruban, R.H.; Cameron, J.L.; Herman, J.M. Adjuvant chemoradiation therapy for adenocarcinoma of the distal pancreas. Ann Surg Oncol. 2010 Dec;17(12):3112-3119.
    31. Ryu, J.K.; Hong, S.M.; Karikari, C.A.; Hruban, R.H.; Goggins, M.G.; Maitra, A. Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology. 2010;10(1):66-73.
    32. Scudiere, J.R.; Shi, C.; Hruban, R.H.; Herman, J.M.; Fishman, E.K.; Schulick, R.D.; Wolfgang, C.L.; Makary, M.A.; Thornton, K.; Montgomery, E.; Horton, K.M. Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer. Am J Surg Pathol. 2010 Apr;34(4):447-453.
    33. Shi, C.; Siegelman, S.S.; Kawamoto, S.; Wolfgang, C.L.; Schulick, R.D.; Maitra, A.; Hruban, R.H. Pancreatic duct stenosis secondary to small endocrine neoplasms: a manifestation of serotonin production? Radiology. 2010 Oct;257(1):107-114.
    34. Swartz, M.J.; Hsu, C.C.; Pawlik, T.M.; Winter, J.; Hruban, R.H.; Guler, M.; Schulick, R.D.; Cameron, J.L.; Laheru, D.A.; Wolfgang, C.L.; Herman, J.M. Adjuvant chemoradiotherapy after pancreatic resection for invasive carcinoma associated with intraductal papillary mucinous neoplasm of the pancreas. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):839-844.
    35. Voong, K.R.; Davison, J.; Pawlik, T.M.; Uy, M.O.; Hsu, C.C.; Winter, J.; Hruban, R.H.; Laheru, D.; Rudra, S.; Swartz, M.J.; Nathan, H.; Edil, B.H.; Schulick, R.; Cameron, J.L.; Wolfgang, C.L.; Herman, J.M. Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients. Hum Pathol. 2010 Jan;41(1):113-122.
    36. Winter, J.M.; Cameron, J.L.; Olino, K.; Herman, J.M.; de Jong, M.C.; Hruban, R.H.; Wolfgang, C.L.; Eckhauser, F.; Edil, B.H.; Choti, M.A.; Schulick, R.D.; Pawlik, T.M. Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. J Gastrointest Surg. 2010 Feb;14(2):379-387.
    37. Yachida, S.; Jones, S.; Bozic, I.; Antal, T.; Leary, R.; Fu, B.; Kamiyama, M.; Hruban, R.H.; Eshleman, J.R.; Nowak, M.A.; Velculescu, V.E.; Kinzler, K.W.; Vogelstein, B.; Iacobuzio-Donahue, C.A. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010 Oct 28;467(7319):1114-1117.
    38. Yamakuchi, M.; Lotterman, C.D.; Bao, C.; Hruban, R.H.; Karim, B.; Mendell, J.T.; Huso, D.; Lowenstein, C.J. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6334-6339.
    39. Jiao, Y.; Shi, C.; Edil, B.H.; de Wilde, R.F.; Klimstra, D.S.; Maitra, A.; Schulick, R.D.; Tang, L.H.; Wolfgang, C.L.; Choti, M.A.; Velculescu, V.E.; Diaz, L.A., Jr.; Vogelstein, B.; Kinzler, K.W.; Hruban, R.H.; Papadopoulos, N. DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors. Science. 2011 Jan 20;In Press.
    40. Lutz, E.; Yeo, C.J.; Lillemoe, K.D.; Biedrzycki, B.; Kobrin, B.; Herman, J.; Sugar, E.; Piantadosi, S.; Cameron, J.L.; Solt, S.; Onners, B.; Tartakovsky, I.; Choi, M.; Sharma, R.; Illei, P.B.; Hruban, R.H.; Abrams, R.A.; Le, D.; Jaffee, E.; Laheru, D. A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation. Ann Surg. 2011 Jan 6;Epub 1/11/11.
    41. Villarroel, M.C.; Rajeshkumar, N.V.; Garrido-Laguna, I.; De Jesus-Acosta, A.; Jones, S.; Maitra, A.; Hruban, R.H.; Eshleman, J.R.; Klein, A.; Laheru, D.; Donehower, R.; Hidalgo, M. Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer. Mol Cancer Ther. 2011 Jan;10(1):3-8.
    42. Hong SM, Goggins M, Wolfgang CL, Schulick RD, Edil BH, Cameron JL, Handra-Luca A, Herman JM, Hruban RH. “Vascular invasion in infiltrating ductal adenocarcinoma of the pancreas can mimic pancreatic intraepithelial neoplasia: a histopathologic study of 209 cases.” Am J Surg Pathol. 2012 Feb;36(2):235-41. doi: 10.1097/PAS.0b013e3182376e36.
    43. Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu VE, Goggins M, Vogelstein B, Papadopoulos N, Hruban RH, Kinzler KW, Klein AP. “ATM mutations in patients with hereditary pancreatic cancer.” Cancer Discov. 2012 Jan;2(1):41-6. doi: 10.1158/2159-8290.CD-11-0194. Epub 2011 Dec 29.
    44. Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA Jr, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N. “DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.” Science. 2011 Mar 4;331(6021):1199-203. doi: 10.1126/science.1200609. Epub 2011 Jan 20.
    45. Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, Eshleman JR, Goggins MG, Wolfgang CL, Canto MI, Schulick RD, Edil BH, Choti MA, Adsay V, Klimstra DS, Offerhaus GJ, Klein AP, Kopelovich L, Carter H, Karchin R, Allen PJ, Schmidt CM, Naito Y, Diaz LA Jr, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. “Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.” Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21188-93. doi: 10.1073/pnas.1118046108. Epub 2011 Dec 8.
    46. Matthaei H, Hong SM, Mayo SC, dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH. “Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer.” Ann Surg Oncol. 2011 Nov;18(12):3493-9. doi: 10.1245/s10434-011-1745-9. Epub 2011 May 3.
    47. Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH. “Genetic mutations associated with cigarette smoking in pancreatic cancer.” Cancer Res. 2009 Apr 15;69(8):3681-8. doi: 10.1158/0008-5472.CAN-09-0015. Epub 2009 Apr 7.
    48. Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, Schulick R, Palmisano E, Hruban RH. “Increased prevalence of precursor lesions in familial pancreatic cancer patients.” Clin Cancer Res. 2009 Dec 15;15(24):7737-7743. Epub .
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Member, German National Academy of Sciences Leopoldina, 2013 - present

    Educational Innovation, Institute for Excellence in Education, 2014

    Distinguished Alumnus Award, The Johns Hopkins University Alumni Association, 2013

    Ruth Leff Siegel Award for Excellence in Pancreatic Cancer Research, Columbia University, 2013

    The Ranice W. Crosby Distinguished Achievement Award, Department of Art as Applied to Medicine, The Johns Hopkins University School of Medicine, 2011

    BioCommunications Association’s Medical Education Award, 2012

    Team Science Award, American Association for Cancer Research

    Ruth C. Brufsky Award of Excellence in Clinical Research for Pancreatic Cancer

    Frank Netter Award for Special Contributions to Medical Education, The Vesalius Trust

    Medical Visionary Award, PanCAN

    Ramzi Cotran Award, The United States and Canadian Academy of Pathology

    Arthur Purdy Stout Prize, The Arthur Purdy Stout Society of Surgical Pathologists

    Professional Activities

    President, The Johns Hopkins Medical and Surgical Association, 2013 - 2015

    Scientific Advisory Board, the Lustgarten Foundation

    Scientific Advisory Board, Joseph C. Monastra Foundation

    Scientific Advisory Board, Michael Rolfe Pancreatic Cancer Foundation

    Pancreatic Cancer Consortium Member, the Lustgarten Foundation

  • Videos & Media +

    Videos

    Ralph Hruban, M.D.

    Dr. Hruban explains the terminology of pancreatic cancer tumors.

  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-2163
    Appointment Phone: 410-955-2163
    Fax: 410-955-0115
    Location Map

    Department/Division

    • Pathology

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