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Jonathan I Epstein, MD

The Reinhard Professor of Urologic Pathology
Professor of Pathology

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Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • The Reinhard Professor of Urologic Pathology
  • Director of Surgical Pathology, The Johns Hopkins Hospital
  • Professor of Pathology
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

  • James Buchanan Brady Urological Institute



Research Interests

Prostatic intraepithelial neoplasia; Adenosis; Diagnosis of limited adenocarcinoma on needle biopsy; Prediction of disease progression following radical prostatectomy


Dr. Jonathan I. Epstein is a professor of pathology, oncology and urology at the Johns Hopkins School of Medicine. He also serves as the Director of Surgical Pathology at The Johns Hopkins Hospital. He is recognized as a leader in the field of urological pathology.

Dr. Epstein completed a combined liberal arts and medical degree program at Boston University, receiving both B.A. and M.D. degrees. He obtained his residency training in anatomic pathology at The Johns Hopkins Hospital, followed by a fellowship in oncological pathology at the Memorial Sloan-Kettering Cancer Center in New York. He has been on the faculty at Johns Hopkins since 1985.

Dr. Epstein lectures widely in the United States and overseas on urological pathology, with emphasis on prostatic and bladder disease, and has written several books and more than 700 articles. Among many awards, he has been honored with the Koss Medal for Advancement of Urological Pathology, the Arthur Purdy Stout Surgical Pathology Prize and the American Cancer Society Clinical Oncology Career Development Award.

He is a member of the American Urologic Association, the Arthur Purdy Stout Society of Surgical Pathologists and the International Society of Urologic Pathology. He holds editorial appointments to 11 medical journals, including American Journal of Surgical Pathology, Urology, Human Pathology and Modern Pathology.


  • English


The United States Canadian Division of the International Academy of Pathology

Phi Beta Kappa, Boston University

Alpha Omega Alpha, Boston University Medical School

American Urologic Association

Arthur Purdy Stout Society of Surgical Pathologists

Maryland Pathology Society

International Society of Urologic Pathology (Executive Council, 1996; Program Committee Chairman, 1977)

National Comprehensive Cancer Network – Prostate Cancer Early Detection Panel

Maryland Department of Health & Mental Hygiene Prostate Medical Advisory Committee

Additional Resources +
  • Education +


    • Boston University School of Medicine (Boston MA ) (1981)


    • Johns Hopkins University School of Medicine / Pathology (Baltimore MD ) (1985)
    • Johns Hopkins Hospital Department of Psychiatry and Behavioral Science (Baltimore MD ) (1983)


    • Memorial Sloan - Kettering Cancer Center (New York NY ) (1984)


    • Anatomic Pathology, American Board of Pathology (1986)
  • Research & Publications +

    Selected Publications View all on PubMed

    1. Tan S, Sood A, Rahimi H, Wang W, Gupta N, Hicks J, Mosier S, Gocke CD, Epstein JI, Netto GJ, Liu W, Isaacs WB, De Marzo AM, Lotan T. “Rb Loss is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma.” Clin Cancer Res. 2013 Dec 9. [Epub ahead of print]
    2. Wang CC, Carter HB, Epstein JI. “Value of Transition Zone Biopsy in Active Surveillance of Prostate Cancer. J Urol. 2013 Dec 5. pii: S0022-5347(13)06016-3. doi: 10.1016/j.juro.2013.11.058. [Epub ahead of print].
    3. Ellis CL, Eble JN, Subhawong AP, Martignoni G, Zhong M, Ladanyi M, Epstein JI, Netto GJ, Argani P. “Clinical heterogeneity of Xp11 translocation renal cell carcinoma: impact of fusion subtype, age, and stage.” Mod Pathol. 2013 Dec 6. doi: 10.1038/modpathol.2013.208. [Epub ahead of print].
    4. Bonekamp D, Bonekamp S, Mullins JK, Epstein JI, Carter HB, Macura KJ. “Multiparametric magnetic resonance imaging characterization of prostate lesions in the active surveillance population: incremental value of magnetic resonance imaging for prediction of disease reclassification.” J Comput Assist Tomogr. 2013 Nov-Dec;37(6):948-56. doi: 10.1097/RCT.0b013e31829ae20a
    5. Takahashi H, Epstein JI, Wakui S, Yamamoto T, Furusato B, Zhang M. ‘Differences in prostate cancer grade, stage, and location in radical prostatectomy specimens from United States and Japan.” Prostate. 2014 Feb;74(3):321-5. doi: 10.1002/pros.22754.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    Koss Medal for Advancement of Urological Pathology, The International Society of Urological Pathology, 2004

    Arthur Purdy Stout Society of Surgical Pathologists Award, 1997

    Test Committee for Anatomic Pathology, American Board of Pathology, 1993-present

    Faculty Teaching Award, The Johns Hopkins Hospital Department of Pathology, 1992

    Clinical Oncology Career Development Award, American Cancer Society, 1988-1991

    Cum Laude, Boston University Medical School, 1981

    Summa Cum Laude, Boston University, 1981

    Alumni Award for Excellence, Boston University, 1981

  • Videos & Media +
  • Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Baltimore, MD 21287
    Phone: 410-614-6330
    Appointment Phone: 410-614-6330
    Location Map
    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-955-2660
    Location Map


    • Pathology

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