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Jonathan I Epstein, M.D.

Photo of Dr. Jonathan I Epstein, M.D.

The Reinhard Professor of Urologic Pathology

Professor of Pathology


Expertise: Pathology

Research Interests: Prediction of disease progression following radical prostatectomy; Diagnosis of limited adenocarcinoma on needle biopsy; Adenosis; Prostatic intraepithelial neoplasia more


The Johns Hopkins Hospital
Appointment Phone: 410-614-6330

401 North Broadway
Weinberg Building, Suite 2242
Baltimore, MD 21231-2410 map
Phone: 410-614-6330

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-955-2660

4940 Eastern Avenue
Baltimore, MD 21224 map


Dr. Jonathan I. Epstein is a professor of pathology, oncology and urology at the Johns Hopkins School of Medicine. He also serves as the Director of Surgical Pathology at The Johns Hopkins Hospital. He is recognized as a leader in the field of urological pathology.

Dr. Epstein completed a combined liberal arts and medical degree program at Boston University, receiving both B.A. and M.D. degrees. He obtained his residency training in anatomic pathology at The Johns Hopkins Hospital, followed by a fellowship in oncological pathology at the Memorial Sloan-Kettering Cancer Center in New York. He has been on the faculty at Johns Hopkins since 1985.

Dr. Epstein lectures widely in the United States and overseas on urological pathology, with emphasis on prostatic and bladder disease, and has written several books and more than 700 articles. Among many awards, he has been honored with the Koss Medal for Advancement of Urological Pathology, the Arthur Purdy Stout Surgical Pathology Prize and the American Cancer Society Clinical Oncology Career Development Award.

He is a member of the American Urologic Association, the Arthur Purdy Stout Society of Surgical Pathologists and the International Society of Urologic Pathology. He holds editorial appointments to 11 medical journals, including American Journal of Surgical Pathology, Urology, Human Pathology and Modern Pathology. more


  • The Reinhard Professor of Urologic Pathology
  • Director of Surgical Pathology, The Johns Hopkins Hospital
  • Professor of Pathology
  • Professor of Oncology
  • Professor of Urology

Departments / Divisions

Centers & Institutes



  • MD, Boston University School of Medicine (1981)


  • Johns Hopkins Hospital Department of Psychiatry and Behavioral Science (1983)
  • Johns Hopkins University School of Medicine / Pathology (1985)


  • Memorial Sloan-Kettering Cancer Center (1984)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (1986)

Research & Publications

Selected Publications

View all on Pubmed

  1. Tan S, Sood A, Rahimi H, Wang W, Gupta N, Hicks J, Mosier S, Gocke CD, Epstein JI, Netto GJ, Liu W, Isaacs WB, De Marzo AM, Lotan T. "Rb Loss is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma." Clin Cancer Res. 2013 Dec 9. [Epub ahead of print]
  2. Wang CC, Carter HB, Epstein JI. "Value of Transition Zone Biopsy in Active Surveillance of Prostate Cancer. J Urol. 2013 Dec 5. pii: S0022-5347(13)06016-3. doi: 10.1016/j.juro.2013.11.058. [Epub ahead of print].
  3. Ellis CL, Eble JN, Subhawong AP, Martignoni G, Zhong M, Ladanyi M, Epstein JI, Netto GJ, Argani P. "Clinical heterogeneity of Xp11 translocation renal cell carcinoma: impact of fusion subtype, age, and stage." Mod Pathol. 2013 Dec 6. doi: 10.1038/modpathol.2013.208. [Epub ahead of print].
  4. Bonekamp D, Bonekamp S, Mullins JK, Epstein JI, Carter HB, Macura KJ. "Multiparametric magnetic resonance imaging characterization of prostate lesions in the active surveillance population: incremental value of magnetic resonance imaging for prediction of disease reclassification." J Comput Assist Tomogr. 2013 Nov-Dec;37(6):948-56. doi: 10.1097/RCT.0b013e31829ae20a
  5. Takahashi H, Epstein JI, Wakui S, Yamamoto T, Furusato B, Zhang M. ‘Differences in prostate cancer grade, stage, and location in radical prostatectomy specimens from United States and Japan." Prostate. 2014 Feb;74(3):321-5. doi: 10.1002/pros.22754.

Epstein JI, Walsh PC, CarMichael M, Brendler CB. Pathological and clinical findings to predict tumor extent of non-palpable (stage T1c) prostate cancer JAMA 271:368-374, 1994. Epstein JI, Allsbrook Jr. WC, Amin MB, Egevad LL & The ISUP grading committee. The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma. Am J Surg Pathol 29: 1228-42, 2005.

Epstein JI, Amin MB, Reuter VR, Mostofi FK, and the Bladder Consensus Conference Committee. The World Health Organization/International Society of Urological Pathology Consensus Classification of Urothelial (Transitional Cell) Neoplasms of the Urinary Bladder. Am J Surg Pathol 22:1435-1448, 1998.

Pan C-C, Potter SR, Partin AW, Epstein, JI. The prognostic significance of tertiary Gleason patterns of higher grade in radical prostatectomy specimens: a proposal to modify the Gleason grading system Am J Surg Pathol 24:563-569, 2000.

Duffield A, Epstein JI. Detection of cancer in radical prostatectomy specimens with no residual carcinoma in the initial specimen. Am J Surg Pathol (January) 33:120-125,2009.

Activities & Honors


  • Koss Medal for Advancement of Urological Pathology, The International Society of Urological Pathology, 2004
  • Arthur Purdy Stout Society of Surgical Pathologists Award, 1997
  • Test Committee for Anatomic Pathology, American Board of Pathology, 1993
  • Faculty Teaching Award, The Johns Hopkins Hospital Department of Pathology, 1992
  • Clinical Oncology Career Development Award, American Cancer Society, 1988 - 1991
  • Cum Laude, Boston University Medical School, 1981
  • Summa Cum Laude, Boston University, 1981
  • Alumni Award for Excellence, Boston University, 1981


  • The United States Canadian Division of the International Academy of Pathology
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