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Esteban Mezey, M.D.

Photo of Dr. Esteban Mezey, M.D.

Chief of Hepatology

Professor of Medicine


Languages: English, Spanish

Expertise: Clinical Gastroenterology, Digestive Diseases, Elevated Liver Tests, Fatty Liver, Gastroenterology, Hemochromatosis, Hepatitis, Jaundice, Liver Cancer, Liver Disease, Liver Mass, Liver Test Abnormalities, Liver Transplant, Nonalcoholic Fatty Liver Disease, Sclerosing Cholangitis more

Research Interests: Liver fibrosis

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The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-933-7495

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-550-0796

4940 Eastern Avenue
Baltimore, MD 21224 map

Johns Hopkins Medicine - Green Spring Station
Appointment Phone: 410-616-7350

2360 W. Joppa Road
Lutherville, MD 21093 map


Dr. Esteban Mezey is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include clinical gastroenterology, digestive diseases and elevated liver tests. He serves as chief of hepatology.

Dr. Mezey earned his M.D. from Harvard Medical School. He completed his residency at St. Luke's Roosevelt Hospital Center, where he also performed a fellowship in gastroenterology.

His research interests include liver fibrosis.

Dr. Mezey is a past president of the American Association for the Study of Liver Diseases. He received the organization’s Distinguished Service Award in 2002. He is a member of several professional organizations, including the American Association for the Study of Liver Diseases, the American Gastroenterological Association and the American Society for Clinical Investigation. more


  • Chief of Hepatology
  • Professor of Medicine



  • MD; Medicine, Harvard Medical School (1962)


  • St Luke's Roosevelt Hospital Center / Medicine (1965)


  • St Luke's Roosevelt Hospital Center / Gastroenterology (1967)

Board Certifications

  • American Board of Internal Medicine / Gastroenterology (1975)
  • American Board of Internal Medicine / Internal Medicine (1970)

Research & Publications

Research Summary

As part of ongoing research, Dr. Mezey investigates the mechanisms of liver fibrosis, focusing on the inhibitory effects of fat-soluble vitamins on fibrosis. The studies are conducted in vitro with stellate cells and in vivo in experimental models of liver fibrosis.

Selected Publications

Potter JJ, Liu X, Koteish A, Mezey E. "1,25-dihydroxyvitamin D3 and its nuclear receptor repress human α1 (I) collagen expression and type I collagen formation." Liver Int. 2013 May;33(5):677-86. doi: 10.1111/liv.12122. Epub 2013 Feb 17.

Potter JJ, Koteish A, Hamilton J, Liu X, Liu K, Agre P, Mezey E. "Effects of acetaldehyde on hepatocyte glycerol uptake and cell size: implication of aquaporin 9." Alcohol Clin Exp Res. 2011 May;35(5):939-45. doi: 10.1111/j.1530-0277.2010.01424.x. Epub 2011 Feb 5.

Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, Maag D, Kim S, Huang AS, Dailey MJ, Saleh M, Snowman AM, Moran TH, Mezey E, Snyder SH. "Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain." Cell. 2010 Dec 10;143(6):897-910. doi: 10.1016/j.cell.2010.11.032.

Kaimori A, Potter JJ, Choti M, Ding Z, Mezey E, Koteish AA. "Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes." Hepatology. 2010 Sep;52(3):1033-45. doi: 10.1002/hep.23765.

Sysa P, Potter JJ, Liu X, Mezey E. "Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors." DNA Cell Biol. 2009 Sep;28(9):425-34. doi: 10.1089/dna.2009.0884.

Activities & Honors


  • Distinguished Service Award, American Association for the study of Liver Diseases, 2002


  • American Association for the Study of liver Diseases
  • American Gastroenterological Association
  • American Society for Clinical Investigation
  • Association of American Physicians
  • Research Society on Alcoholism

Professional Activities

  • President, American Association for the Study of Liver Diseases, 1993
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