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Roy G Brower, M.D.
Medical Director, Medical Intensive Care Unit
Professor of Medicine
Expertise: Acute Lung Injury, Acute Respiratory Distress Syndrome, Critical Care Medicine, Pulmonary Disease and Critical Care Medicine, Pulmonary Medicine, Respiratory Failure ...read more
Research Interests: Ventilation-associated lung injury; Acute respiratory distress syndrome (ARDS); Clinical and translational research in acute lung injury; Respiratory failure; Acute Lung Injury; Acute Respiratory Distress Syndrome; Critical Care Medicine ...read more
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Dr. Roy G. Brower is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include acute lung injury, acute respiratory distress syndrome (ARDS) and critical care medicine. Dr. Brower serves as the medical director of the Medical Intensive Care Unit.
He earned his M.D. from Johns Hopkins. He completed his residency and performed a fellowship in pulmonary and critical care medicine at Johns Hopkins.
Dr. Brower's research interests include ventilation-associated lung injury, ARDS, and clinical and translational research in acute lung injury.
He served as reviewer for the Johns Hopkins Hospital 2015-2016 Antibiotics Guidelines. He has been recognized with several honors, including the Departmental Teaching Award from the Johns Hopkins Institute for Excellence in Education and the Lifetime Achievement Award from the Critical Care Assembly of the American Thoracic Society. He is a member of the American Thoracic Society and the Society of Critical Care Medicine.
- Medical Director, Medical Intensive Care Unit
- Professor of Medicine
Departments / Divisions
Centers & Institutes
- MD; Medicine, Johns Hopkins University School of Medicine (1976)
- Johns Hopkins University School of Medicine / Internal Medicine (1979)
- Johns Hopkins University School of Medicine / Pulmonary and Critical Care Medicine (1984)
- American Board of Internal Medicine / Internal Medicine (1979)
- American Board of Internal Medicine / Pulmonary Disease (1984)
Research & Publications
Dr. Brower has led or contributed to a dozen clinical trials looking at the management of acute respiratory distress syndrome (ARDS). He also studies oxygen toxicity, a condition that results from receiving too much supplemental oxygen.
Clinical Trial KeywordsARDS, Acute respiratory distress syndrome, Acute lung injury
Selected PublicationsView all on Pubmed
Truong AD, Kho ME, Brower RG, Feldman DR, Colantuoni E, Needham DM. "Effects of neuromuscular electrical stimulation on cytokines in peripheral blood for healthy participants: a prospective, single-blinded Study." Clin Physiol Funct Imaging. 2015 Oct 16. doi: 10.1111/cpf.12290. [Epub ahead of print]
Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, Stewart TE, Briel M, Talmor D, Mercat A, Richard JC, Carvalho CR, Brower RG. "Driving pressure and survival in the acute respiratory distress syndrome." N Engl J Med. 2015 Feb 19;372(8):747-55. doi: 10.1056/NEJMsa1410639.
Denney JA, Capanni F, Herrera P, Dulanto A, Roldan R, Paz E, Jaymez AA, Chirinos EE, Portugal J, Quispe R, Brower RG, Checkley W; INTENSIVOS Cohort Study. "Establishment of a prospective cohort of mechanically ventilated patients in five intensive care units in Lima, Peru: protocol and organisational characteristics of participating centres." BMJ Open. 2015 Jan 16;5(1):e005803. doi: 10.1136/bmjopen-2014-005803.
Needham DM, Yang T, Dinglas VD, Mendez-Tellez PA, Shanholtz C, Sevransky JE, Brower RG, Pronovost PJ, Colantuoni E. "Timing of low tidal volume ventilation and intensive care unit mortality in acute respiratory distress syndrome. A prospective cohort study." Am J Respir Crit Care Med. 2015 Jan 15;191(2):177-85. doi: 10.1164/rccm.201409-1598OC.
Eberlein M, Reed RM, Bolukbas S, Diamond JM, Wille KM, Orens JB, Brower RG, Christie JD; Lung Transplant Outcomes Group. "Lung size mismatch and primary graft dysfunction after bilateral lung transplantation." J Heart Lung Transplant. 2015 Feb;34(2):233-40. doi: 10.1016/j.healun.2014.09.030. Epub 2014 Sep 28.
Kamdar BB, Yang J, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Brower RG, Collop NA, Needham DM. Developing, Implementing, and Evaluating a Multifaceted Quality Improvement Intervention to Promote Sleep in an ICU. Am J Med Qual. 2013 Nov 22. [Epub ahead of print] PMID: 24270169
Eberlein M, Reed RM, Maidaa M, Bolukbas S, Arnaoutakis GJ, Orens JB, Brower RG, Merlo CA, Hunsicker LG. Donor-recipient size matching and survival after lung transplantation. A cohort study. Ann Am Thorac Soc. 2013 Oct;10(5):418-25. doi: 10.1513/AnnalsATS.201301-008OC. PMID: 23988005
Brower RG. Time to reach a new equilibrium after changes in PEEP in acute respiratory distress syndrome patients. Intensive Care Med. 2013 Nov;39(11):2053-5. No abstract available. PMID: 23958739
Eberlein M, Reed RM, Bolukbas S, Parekh KR, Arnaoutakis GJ, Orens JB, Brower RG, Shah AS, Hunsicker L, Merlo CA. Lung size mismatch and survival after single and bilateral lung transplantation. Ann Thorac Surg. 2013 Aug;96(2):457-63. doi: 10.1016/j.athoracsur.2013.04.064. Epub 2013 Jun 26. PMID: 23809729
Hager DN, Dinglas VD, Subhas S, Rowden AM, Neufeld KJ, Bienvenu OJ, Touradji P, Colantuoni E, Reddy DR, Brower RG, Needham DM. Reducing deep sedation and delirium in acute lung injury patients: a quality improvement project. Crit Care Med. 2013 Jun;41(6):1435-42. doi: 10.1097/CCM.0b013e31827ca949. PMID: 23507716
Prescott HC, Brower RG, Cooke CR, Phillips G, O'Brien JM; Factors associated with elevated plateau pressure in patients with acute lung injury receiving lower tidal volume ventilation. National Institutes of Health Acute Respiratory Distress Syndrome Investigators. Crit Care Med. 2013 Mar;41(3):756-64. doi: 10.1097/CCM.0b013e3182741790. PMID: 23328258
Kamdar BB, King LM, Collop NA, Sakamuri S, Colantuoni E, Neufeld KJ, Bienvenu OJ, Rowden AM, Touradji P, Brower RG, Needham DM. The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med. 2013 Mar;41(3):800-9. doi: 10.1097/CCM.0b013e3182746442. PMID: 23314584
Dezube R, Arnaoutakis GJ, Reed RM, Bolukbas S, Shah AS, Orens JB, Brower RG, Eberlein M. The effect of lung-size mismatch on mechanical ventilation tidal volumes after bilateral lung transplantation. Interact Cardiovasc Thorac Surg. 2013 Mar;16(3):275-81. doi: 10.1093/icvts/ivs493. Epub 2012 Dec 12. PMID: 23243035
Miller RR 3rd, Macintyre NR, Hite RD, Truwit JD, Brower RG, Morris AH. Point: should positive end-expiratory pressure in patients with ARDS be set on oxygenation? Yes. Chest. 2012 Jun;141(6):1379-82; discussion 1386-7. doi: 10.1378/chest.12-0155. No abstract available. PMID: 22670017
Needham DM, Colantuoni E, Mendez-Tellez PA, Dinglas VD, Sevransky JE, Dennison Himmelfarb CR, Desai SV, Shanholtz C, Brower RG, Pronovost PJ. Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study. BMJ. 2012 Apr 5;344:e2124. doi: 10.1136/bmj.e2124. PMID: 22491953
Activities & Honors
- Departmental Teaching Award, Johns Hopkins Institute for Excellence in Education, 2015
- Lifetime Achievement Award, Critical Care Assembly, American Thoracic Society, 2015
- William J. Martin Distinguished Achievement Award, American Thoracic Society Public Advisory Roundtable, 2010
- American Thoracic Society
- Society of Critical Care Medicine
- Reviewer, Antibiotic Guidelines, Johns Hopkins, 2015