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James C Harris, M.D.

Director, Developmental Neuropsychiatry Clinic
Professor of Psychiatry and Behavioral Sciences

Male  | Languages: English, Thai

Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Developmental Neuropsychiatry Clinic
  • Professor of Psychiatry and Behavioral Sciences
  • Joint Appointment in History of Medicine
  • Professor of Pediatrics

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-614-2401

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-614-2401
Fax: 410-955-8691


Adult Psychiatry , Child and Adolescent Psychiatry , Child Development and Behavioral Health , Lesch-Nyhan Disease, Neurodevelopmental Disorders, Psychiatry

Research Interests

Neurogenetic syndromes, autism, ADHD, Sleep Disorders


1976 Director of Developmental Neuropsychiatry, The Johns Hopkins University School of Medicine
1976-1992 Director of Developmental Neuropsychiatry Kennedy Krieger Institute
1978 1982 Interim Director, Division of Child Psychiatry, Johns Hopkins University School of Medicine
1978 1982 Director Consultation/ Liaison, Division of Child Psychiatry, Johns Hopkins University School of Medicine
1978 1984 Adjunct Scientist, Laboratory of Brain Evolution and Behavior, Poolesville, MD (Paul MacLean, M. D., Chief)
1982 1989 Director of Education, Division of Child Psychiatry, Johns Hopkins University
1983 Co-Founder Autism Clinic, Kennedy Krieger Institute
1984 1992 Adjunct Scientist Laboratory of Comparative Ethology (Steven Suomi, Ph.D., Chief)
1986 1988 President of the Medical Staff (First Elected President), Kennedy Krieger Institute
1992 U. S. Representative, Society for the Study of Behavioral Phenotype
1998 2000 President, Society for Professors of Child & Adolescent Psychiatry
1998 Visiting Professor, Guys and St. Thomas Hospitals, London
2001 2002 Visiting Scholar, University of Chicago (Dept. of Psychiatry: Institute of Mind and Biology) more

    Additional Information

  • Education +


    • George Washington University School of Medicine / MD (1966)


    • American Board of Pediatrics / Pediatrics (1974)
    • American Board of Psychiatry & Neurology / Child And Adolescent Psychiatry (1981)
    • American Board of Psychiatry & Neurology / Psychiatry (1980)
  • Research & Publications +

    Research Summary

    My research is in Developmental Neuropsychiatry, focused on behavioral phenotypes in neurogenetic disorder. I have authored a textbook written to establish this field as subspecialty in psychiatry. This two volume book was chosen as medical book of the year among 2500 medical books in 76 specialties in the year of publication. The NIH awarded me support through an R-01 to study Lesch-Nyhan disease. Psychopharmacology in Neurodevelopmental disorders is another area of research interest. I am a fellow of the American College of Neuropsychopharmacology. I work as the cover editor for the journal JAMA Psychiatry for the Art and Images section and choose the cover each month and write a commentary about a psychiatric theme represented in this work. In the general department I teach a course on personality that focuses on the work of Adolph Meyer, Erik Erikson, John Bowlby and Carl Jung. I write the psychiatry section for the Oski Textbook of Pediatrics (now in the third edition) and the section of purine and pyrimidines for the Nelson Textbook of Pediatrics.

    Clinical Trial Keywords: Neurodevelopmental Disorders

    Selected Publications

    1. Harris JC Behavioral phenotypes of neurodevelomental disorders: portals into the developing brain. In Davis,KL Coyle,JT, Charney,D and Nemeroff C. (eds.), Psychopharmacology: the Fifth Generation of Progress, American College of Psychopharmacology, Nashville, TN, 2001.
    2. Horska, A., Kaufmann, W. E., Brant, L. J., Naidu, S., Harris, J. C., and Barker, P. B. 2002. In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging, 15(2):137-143.
    3. Harris, J.C. Social Neuroscience, integrated brain function, empathy and neurodevelopmental disorders. Physiology and Behavior. 79(3):525-31, 2003.
    4. Fairbanks LD, Harris JC, Duley JA, Simmonds HA. Nucleotide degradation products in cerebrospinal fluid (CSF) in inherited and acquired pathologies. Nucleosides Nucleotides Nucleic Acids. 23:1185-1187, 2004.
    5. De Gregorio L, Jinnah HA, Harris JC, Nyhan WL, Schretlen DJ, Trombley LM,O''Neill JP. Lesch-Nyhan disease in a female with a clinically normal monozygotic twin.Mol Genet Metab. 85:70-7, 2005

      B. Selected Publications

    6. Schretlen DJ, Ward J, Meyer SM, Yun J, Puig JG, Nyhan WL, Jinnah HA, Harris JC. Behavioral aspects of Lesch-Nyhan disease and its variants. Dev Med Child Neurol. 47:673-677, 2005
    7. Jinnah HA, Visser JE, Harris JC, Verdu A, Larovere L, Ceballos-Picot I et al Delineation of the motor disorder of Lesch-Nyhan disease. Brain. 129(Pt 5):1201-1217, 2006
    8. Harris, JC. (2007)The evolutionary biology, emergence, and facilitation of empathy. In Farrow, M. (ed) Empathy and Mental Illness. Cambridge University Press. Cambridge, England.
    9. Harris, JC. . (2007) Psychiatric Disorders in Persons with Intellectual Disability. In Gabbard, G. (ed) Treatments of Psychiatric Disorders,American Psychiatric Association Press, Washington, D. C Harris, JC., 2007
    10. Harris, JC. Disorders of Purine and Pyrimidine Metabolism In Kliegman, R.M., Behrman, R.E, . Jenson, H.B. and Stanton, B. Nelson Textbook of Pediatrics,18th Edition. W.B. Saunders, Philadelphia, 2007.
    11. Harris, J.C. Developmental Neuropsychiatric Disorders. In New Oxford Textbook of Psychiatry. Gelder, M. , Lopez-Ibor, JJ, Andreasen, N. (eds) Oxford University Press. Oxford, U.K. 2009
    12. Harris, JC. Brain Disorders and their effect on psychopathology. In Rutter, M. (ed). Rutters Textbook of Child and Adolescent Psychiatry. Blackwell, London. 2008
    13. Hong CC, Harris JC, Pearlson GD, Kim JS, Calhoun VD, Fallon JH, Golay X, Gillen JS, Simmonds DJ, van
    14. Zijl PC, Zee DS, Pekar JJ. fMRI evidence for multisensory recruitment associated with rapid eye movements during sleep.Hum Brain Mapp. 2009 Oct 28. [Epub ahead of print]
    15. Books, Series Editorships, and Monthly Commentaries
    16. Harris J. (1998). Developmental neuropsychiatry. Volume 1: Fundamentals of developmental neuropsychiatry. Volume 2: Assessment, diagnosis and treatment of the developmental disorders. Oxford University Press, New York. (Medical Book of the Year, 1995)
    17. Harris, J. (2006). Intellectual Disability: Understanding Its Development, Causes, Classification, Evaluation, and Treatment. Oxford University Press, New York.
    18. Harris, J. Book Series Editor, Developmental Perspectives in Psychiatry. Oxford University Press.
    19. Harris, J. Art and Images Editor. Archives of General Psychiatry. Monthly Commentaries on Art and Science.. (75 commentaries published 2002-January 2009 in 10 topic areas)


    Recently Completed Research Support
    R01 HD33095 (Harris, PI) 4/8/973/31/01
    Behavior and Neurobiological Correlates of HPRT Deficiency
    This study aimed to quantify behavioral, cognitive, and neuroanatomic aspects of HPRT deficiency

    (Harris, PI) 11/6/972/1/06
    Lesch-Nyhan Syndrome Childrens Research
    MRI and PET studies of Lesch-Nyhan disease

    Current Research Support.

    Lesch-Nyhan Disease: Neuroanatomical and Biochemical
    Bases of the Phenotype 1 R01 HD053312-01A2 2008-2012
    Schrelen (PI.) Harris (co-investigator)

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Honors Outstanding Teacher Award, 1989
    • Honors Outstanding Teacher Award, Sabbatical Year (Full-Time), 1992 - 1993
    • Medical Book of the Year, Developmental Neuropsychiatry (2 vols. Single Author), 1995
    • Honors Outstanding Teacher Award, 1996
    • Honors Outstanding Teacher Award, 1998
    • Honors Outstanding Teacher Award, 1999
    • Fellow, American College of Neuropsychopharmacology, 2002
    • Who's Who in America, 2002
    • Who's Who in the World, 2002
    • American College of Psychiatrists, 2003
    • APA Agnes Purcell McGavin Award for Distinguished Career Achievement in Child and Adolescent Psychiatry, 2007


    • Academy of Psychiatry and the Law, 1987
    • American Academy of Child and Adolescent Psychiatry, 1980
    • American Academy of Child/Adolescent Psychiatry, 1985
    • American Association for the Advancement of Science, 1983
    • American Association of Directors of Psychiatric Residency Training, 1983
    • American Psychiatric Association, 1993
    • American Psychiatric Association, 2007
      Life Fellow
    • American Psychiatric Association, 1978
    • American Sleep Disorders Association/Society for Sleep Research, 1984
    • American Society of Clinical Psychopharmacology, 1995
    • Maryland Psychiatric Society, 1978
    • Maryland Regional Council for Child and Adolescent Psychiatry, 1986 - 1988
    • New York Academy of Medicine, 1993
    • Society for Neuroscience, 1984
    • Society of Professors of Child and Adolescent Psychiatry, 1998 - 2000
    • United States Representative, International Society for the Study of Behavioral Phenotypes, 1992

    Professional Activities

    • Outstanding Teacher Award, 1999
    • American College of Psychiatrists, 2003
    • Award for Distinguished Career Achievement in Child and Adolescent Psychiatry. , APA Agnes Purcell McGavin, 2007
    • Editorial Boards, Archives of General Psychiatry, 2002
      Art and Images editor
    • Editorial Boards, Journal of Child Neurology, 2001 - 2007
    • Medical Book of the Year, Developmental Neuropsychiatry (2 volumes, Single Author), 1995
    • Whos Who in America, 2002
    • Whos Who in the World, 2002
  • Videos & Media +
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