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Brigitte Maria Ronnett, M.D.

Photo of Dr. Brigitte Maria Ronnett, M.D.

Professor of Pathology

Female

Expertise: Pathology

Research Interests: Gynecologic pathology; molecular diagnosis of molar pregnancy; pathology of mucinous ovarian neoplasm; clinicopathological characterization of gynecologic neoplasms ...read more

Locations

The Johns Hopkins Hospital

401 North Broadway
Pathology, Weinberg Building, Suite 2242
Baltimore, MD 21231-2410 map
Phone: 410-614-2971

Background

Dr. Brigitte M. Ronnett is Professor of Pathology and Gynecology & Obstetrics at The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD. She is a diagnostic pathologist and clinical researcher whose accomplishments in clinical service, education and research have established her as a nationally and internationally recognized expert in gynecologic pathology. Dr. Ronnett graduated from Northwestern University, Evanston, IL (B.A. chemistry, 1982). She received her medical degree from the University Of Chicago Pritzker School Of Medicine, Chicago, IL (M.D., 1986). She completed residency training in anatomic and clinical pathology at The Johns Hopkins Hospital, Baltimore, MD, (anatomic: 1986-1989; clinical: 1991-1993). She also completed a 1-year surgical pathology fellowship at Memorial Sloan-Kettering Cancer Center, New York, NY (1989-1990) and a 1-year surgical pathology fellowship/chief residency at The Johns Hopkins Hospital, Baltimore, MD (1990-1991). She then completed a 2-year subspecialty fellowship in gynecologic pathology at The Johns Hopkins Hospital, Baltimore, MD (1993-1995). She joined the faculty of the Department of Pathology at The Johns Hopkins Hospital in 1995 and achieved the rank of Full Professor in 2007. Her clinical efforts are focused on a large gynecologic pathology consultation practice at The Johns Hopkins Hospital. Her research efforts have focused on the following topics: 1. ovarian mucinous tumors (distinction of primary and metastatic mucinous tumors in the ovaries, the origin of pseudomyxoma peritonei in women), 2. uterine cervical and endometrial pathology (HPV-related cervical lesions, ancillary techniques for distinction of endocervical and endometrial adenocarcinomas and subtyping of endometrial adenocarcinomas), and 3. hydatidiform moles (ancillary techniques for refined diagnosis).

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Titles

  • Professor of Pathology
  • Professor of Gynecology and Obstetrics

Education

Degrees

  • MD; Medicine, The University of Chicago Pritzker School of Medicine (1986)

Residencies

  • Johns Hopkins University School of Medicine / Pathology (1989)
  • Johns Hopkins University School of Medicine / Pathology Laboratory Medicine (1993)

Fellowships

  • Johns Hopkins University School of Medicine (1990)
  • Memorial Sloan-Kettering Cancer Center / Pathology (1990)
  • Johns Hopkins University School of Medicine (1995)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (1991)
  • American Board of Pathology / Clinical Pathology (1993)

Research & Publications

Research Summary

Dr. Ronnett is a diagnostic pathologist and clinical researcher whose accomplishments in clinical service, education, and research have established her as a nationally and internationally recognized expert in gynecologic pathology. As a clinical researcher, her work has addressed a wide variety of topics in gynecologic pathology. Within this specialty, her research efforts have focused on the following topics:

  1. ovarian mucinous tumors, with emphasis on distinction of primary and metastatic mucinous tumors in the ovaries and clarifying the origin of pseudomyxoma peritonei in women,
  2. uterine cervical and endometrial pathology, with emphasis on ancillary techniques for distinction of endocervical and endometrial adenocarcinomas and subtyping of endometrial adenocarcinomas,
  3. utility of ancillary techniques for refined diagnosis of hydatidiform moles,
  4. collaborative funded studies on HPV and cervical lesions for which she functions as a nationally recognized expert for adjudicating anogenital biopsy diagnoses.

Her work on ovarian mucinous tumors has contributed to refined diagnosis of these tumors, clarification of their behavior and relationship to pseudomyxoma peritonei, and improved recognition of metastatic tumors that simulate primary ovarian tumors. In particular, her work on the relationship between ovarian mucinous tumors and pseudomyxoma peritonei has contributed to a new understanding of this condition as a unique clinicopathologic syndrome of appendiceal (not ovarian) origin and led to the creation of a new pathologic classification system for peritoneal mucinous tumors that is prognostically relevant and has been adopted by pathologists and clinicians nationally and internationally.

Selected Publications

View all on Pubmed

Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM. Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to pseudomyxoma peritonei. Am J Surg Pathol 1995;19(12):1390-1408. PMID: 7503361

Ronnett BM, Kajdacsy-Balla A, Gilks CB, Merino MJ, Silva E, Werness BA, Young RH. Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. Hum Pathol 2004;35(8):949-960. PMID: 15297962

Ronnett BM, DeScipio C, Murphy KM. Hydatidiform moles: ancillary techniques to refine diagnosis. Int J Gynecol Pathol 2011;30(2):101-116. PMID: 21293291

Ronnett BM. Endocervical adenocarcinoma: selected diagnostic challenges. Mod Pathol 2016;29(Suppl 1):S12-28. PMID: 26715171

Hui P, Buza N, Murphy KM, Ronnett BM. Hydatidiform moles: genetic basis and precision diagnosis. Ann Rev Pathol 2017;12:449-485. PMID: 28135560

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