Dr. Ronnett is a diagnostic pathologist and clinical researcher whose accomplishments in clinical service, education, and research have established her as a nationally and internationally recognized expert in gynecologic pathology. As a clinical researcher, her work has addressed a wide variety of topics in gynecologic pathology. Within this specialty, her research efforts have focused on the following topics:
- ovarian mucinous tumors, with emphasis on distinction of primary and metastatic mucinous tumors in the ovaries and clarifying the origin of pseudomyxoma peritonei in women,
- uterine cervical and endometrial pathology, with emphasis on ancillary techniques for distinction of endocervical and endometrial adenocarcinomas and subtyping of endometrial adenocarcinomas,
- utility of ancillary techniques for refined diagnosis of hydatidiform moles,
- collaborative funded studies on HPV and cervical lesions for which she functions as a nationally recognized expert for adjudicating anogenital biopsy diagnoses.
Her work on ovarian mucinous tumors has contributed to refined diagnosis of these tumors, clarification of their behavior and relationship to pseudomyxoma peritonei, and improved recognition of metastatic tumors that simulate primary ovarian tumors. In particular, her work on the relationship between ovarian mucinous tumors and pseudomyxoma peritonei has contributed to a new understanding of this condition as a unique clinicopathologic syndrome of appendiceal (not ovarian) origin and led to the creation of a new pathologic classification system for peritoneal mucinous tumors that is prognostically relevant and has been adopted by pathologists and clinicians nationally and internationally.
- Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM. Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to pseudomyxoma peritonei. Am J Surg Pathol 1995;19:1390-1408.
- Ronnett BM, Yan H, Kurman RJ, Shmookler BM, Wu L, Sugarbaker PH. Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosis. Cancer 2001;92:85-91.
- Ronnett BM, Kajdacsy-Balla A, Gilks CB, Merino MJ, Silva E, Werness BA, Young RH. Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. Hum Pathol 2004;35:949-960.
- Vang R, Ronnett BM. Distinction of primary ovarian mucinous tumors and mucinous tumors metastatic to the ovary: a practical approach with guidelines for prediction of primary site for metastases of uncertain origin. Pathol Case Rev 2006;11:18-30.
- Yemelyanova AV, Vang R, Judson K, Wu LSF, Ronnett BM. Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with re-evaluation of an algorithm for tumor classification. Am J Surg Pathol 2008;32:128-138.
- Ronnett BM, Yemelyanova AV, Vang R, Gilks CB, Miller D, Gravitt PE, Kurman RJ. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases, with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol 2008;32:1835-1853.
- Staebler A, Sherman ME, Zaino RJ, Ronnett BM. Hormone receptor immunohistochemistry and HPV in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomas. Am J Surg Pathol 2002;26:998-1006.
- Ansari-Lari MA, Staebler A. Zaino RJ, Shah KV, Ronnett BM. Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detection. Am J Surg Pathol 2004;28:160-167.
- Yemelyanova A, Ji H, Shih IM, Wang TL, Wu LSF, Ronnett BM. Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. Am J Surg Pathol 2009;33:1504-1514.
- McConnell TG, Murphy KM, Hafez M, Vang R, Ronnett BM. Diagnosis and subclassification of hydatidiform moles utilizing p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approach. Am J Surg Pathol 2009;33:805-817.
- Murphy KM, McConnell TG, Hafez MJ, Vang R, Ronnett BM. Molecular genotyping of hydatidiform moles: analytic validation of a multiplex short tandem repeat (STR) assay. J Molec Diagn 2009;11:598-605.
- Cai B, Ronnett BM, Stoler M, Ferenczy A, Kurman RJ, Sadow D, Alvarez F, Pearson J, Sings H, Barr E, Liaw K-L. Longitudinal evaluation of interobserver and intraobserver agreement of cervical intraepithelial neoplasia diagnosis among an experienced panel of gynecologic pathologists. Am J Surg Pathol 2007;31:1854-1860.
- Lacey JV Jr, Ioffe OB, Ronnett BM, Rush BB, Richesson DA, Chatterjee N, Langholz B, Glass AG, Sherman ME. Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan. Br J Cancer 2008;98:45-53.
- Sherman ME, Ronnett BM, Ioffe OB, Richesson DA, Rush BB, Glass AG, Chatterjee N, Duggan MA, Lacey JV Jr. Reproducibility of biopsy diagnoses of endometrial hyperplasia: evidence supporting a simplified classification. Int J Gynecol Pathol 2008;27:318-325.
- Kurman RJ, Ronnett BM, Sherman ME, Wilkinson EJ. Tumors of the Cervix, Vagina, and Vulva. Atlas of Tumor Pathology, Series 4, Washington, DC: American Registry of Pathology, Armed Forces Institute of Pathology, 2010 (In Press).