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Brigitte Maria Ronnett, M.D.

Photo of Dr. Brigitte Maria Ronnett, M.D.

Professor of Pathology

Female

Expertise: Pathology

Research Interests: Gynecologic pathology

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Locations

The Johns Hopkins Hospital
Appointment Phone: 443-287-4996

Pathology
401 North Broadway
Weinberg Building, Suite 2242
Baltimore, MD 21231-2410 map
Phone: 410-614-2971

Background

Dr. Brigitte Ronnett is a professor of pathology and gynecology and obstetrics at the Johns Hopkins University School of Medicine. She is a diagnostic pathologist and clinical researcher whose accomplishments in clinical service, education and research have established her as a nationally and internationally recognized expert in gynecologic pathology.

Dr. Ronnett received her undergraduate degree in chemistry from Northwestern University. She earned her M.D. from the Pritzker School of Medicine at the University of Chicago. She completed her residency in anatomic and clinical pathology at the Johns Hopkins University School of Medicine.  She completed a fellowship in surgical pathology at the Memorial Sloan-Kettering Cancer Center. She also completed fellowships in surgical pathology and gynecologic pathology, both at Johns Hopkins.

She is a cervical dysplasia expert at the Center for Cervical Dysplasia and a co-investigator at the Cervical Cancer SPORE at Johns Hopkins.

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Titles

  • Professor of Pathology
  • Professor of Gynecology and Obstetrics

Education

Degrees

  • MD; Medicine, The University of Chicago Pritzker School of Medicine (1986)

Residencies

  • Johns Hopkins University School of Medicine / Pathology (1989)
  • Johns Hopkins University School of Medicine / Pathology Laboratory Medicine (1993)

Fellowships

  • Johns Hopkins University School of Medicine (1990)
  • Memorial Sloan-Kettering Cancer Center / Pathology (1990)
  • Johns Hopkins University School of Medicine (1995)
  • Johns Hopkins University School of Medicine / Pathology (1995)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (1991)
  • American Board of Pathology / Clinical Pathology (1993)

Research & Publications

Research Summary

Dr. Ronnett is a diagnostic pathologist and clinical researcher whose accomplishments in clinical service, education, and research have established her as a nationally and internationally recognized expert in gynecologic pathology. As a clinical researcher, her work has addressed a wide variety of topics in gynecologic pathology. Within this specialty, her research efforts have focused on the following topics:

  1. ovarian mucinous tumors, with emphasis on distinction of primary and metastatic mucinous tumors in the ovaries and clarifying the origin of pseudomyxoma peritonei in women,
  2. uterine cervical and endometrial pathology, with emphasis on ancillary techniques for distinction of endocervical and endometrial adenocarcinomas and subtyping of endometrial adenocarcinomas,
  3. utility of ancillary techniques for refined diagnosis of hydatidiform moles,
  4. collaborative funded studies on HPV and cervical lesions for which she functions as a nationally recognized expert for adjudicating anogenital biopsy diagnoses.

Her work on ovarian mucinous tumors has contributed to refined diagnosis of these tumors, clarification of their behavior and relationship to pseudomyxoma peritonei, and improved recognition of metastatic tumors that simulate primary ovarian tumors. In particular, her work on the relationship between ovarian mucinous tumors and pseudomyxoma peritonei has contributed to a new understanding of this condition as a unique clinicopathologic syndrome of appendiceal (not ovarian) origin and led to the creation of a new pathologic classification system for peritoneal mucinous tumors that is prognostically relevant and has been adopted by pathologists and clinicians nationally and internationally.

Selected Publications

View all on Pubmed

Kurman RJ, Ellenson LH, Ronnett BM (eds), Blaustein's Pathology of the Female Genital Tract, 6th ed., New York, NY: Springer Verlag, 2011.

Kurman RJ, Ronnett BM, Sherman ME, Wilkinson EJ. Tumors of the Cervix, Vagina, and Vulva. AFIP Atlas of Tumor Pathology, Series 4 (#13). Washington, DC: American Registry of Pathology, Armed Forces Institute of Pathology, 2010

Longacre T, Bell D, Malpica A, Prat J, Ronnett BM, Seidman JD, Vang R. Tumours of the ovary: Epithelial-stromal tumours – Mucinous tumours. In: Kurman RJ, Carcangiu ML, Herrington S, Young RH, eds. World Health Organization Classification of Tumours of Female Reproductive Organs, 4th Edition. Lyon, France: IARC Press, 2014.

Vang R, Cheung ANY, Kommoss F, Matias-Guiu X, Ronnett BM, Young RH. Tumours of the ovary: Secondary tumours. In: Kurman RJ, Carcangiu ML, Herrington S, Young RH, eds. World Health Organization Classification of Tumours of Female Reproductive Organs, 4th Edition. Lyon, France: IARC Press, 2014.

Hui P, Baergen R, Cheung ANY, Fukunaga N, Gersell D, Lage JM, Ronnett BM, Sebire NJ, Wells M. Gestational trophoblastic disease. In: Kurman RJ, Carcangiu ML, Herrington S, Young RH, eds. World Health Organization Classification of Tumours of Female Reproductive Organs, 4th Edition. Lyon, France: IARC Press, 2014.

Wilbur D, Colgan T, Ferenczy A, Hirschowitz L, Loening T, McCluggage WG, Mikami Y, Park K, Ronnett BM, Schneider A, Wells M, Wright TC. Tumours of the uterine cervix: Epithelial tumours – Glandular tumours and precursors. In: Kurman RJ, Carcangiu ML, Herrington S, Young RH, eds. World Health Organization Classification of Tumours of Female Reproductive Organs, 4th Edition. Lyon, France: IARC Press, 2014.

Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM. Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to pseudomyxoma peritonei. Am J Surg Pathol 1995;19(12):1390-1408. PMID 7503361

Ronnett BM, Yan H, Kurman RJ, Shmookler BM, Wu L, Sugarbaker PH. Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosis. Cancer 2001;92(1):85-91. PMID 11443613

Ronnett BM, Kajdacsy-Balla A, Gilks CB, Merino MJ, Silva E, Werness BA, Young RH. Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. Hum Pathol 2004;35(8):949-960. PMID 15297962

Yemelyanova AV, Vang R, Judson K, Wu LSF, Ronnett BM. Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with re-evaluation of an algorithm for tumor classification. Am J Surg Pathol 2008;32(1):128-138. PMID 18162780

Ronnett BM, Yemelyanova AV, Vang R, Gilks CB, Miller D, Gravitt PE, Kurman RJ. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases, with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol 2008;32(12):1835-1853. PMID 18813124

McConnell TG, Murphy KM, Hafez M, Vang R, Ronnett BM. Diagnosis and subclassification of hydatidiform moles utilizing p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approach. Am J Surg Pathol 2009;33(6):805-817. PMID: 19145201

Murphy KM, McConnell TG, Hafez MJ, Vang R, Ronnett BM. Molecular genotyping of hydatidiform moles: analytic validation of a multiplex short tandem repeat (STR) assay. J Molec Diagn 2009;11(6):598-605. PMID: 19815697

Meriden Z, Yemelyanova A, Vang R, Ronnett BM. Ovarian metastases of pancreaticobiliary tract adenocarcinomas: analysis of 35 cases, with emphasis on the ability of metastases to simulate primary ovarian mucinous tumors. Am J Surg Pathol 2011;35(2):276-288. PMID: 21263249

Ronnett BM, DeScipio C, Murphy KM. Hydatidiform moles: ancillary techniques to refine diagnosis. Int J Gynecol Pathol 2011;30(2):101-116. PMID: 21293291

Vang R, Gupta M, Wu LSF, Yemelyanova AV, Kurman RJ, Murphy KM, DeScipio C, Ronnett BM. Diagnostic reproducibility of hydatidiform moles: ancillary techniques (p57 immunohistochemistry and molecular genotyping) improve morphologic diagnosis. Am J Surg Pathol 2012;36(3):443-453. PMID: 22245958

Lewis GH, DeScipio C, Murphy KM, Haley L, Beierl K, Mosier S, Tandy S, Cohen DS, Lytwyn A, Elit L, Vang R, Ronnett BM. Characterization of androgenetic/biparental mosaic/chimeric conceptions, including some with a molar component: morphology, p57 immunohistochemistry, molecular genotyping, and risk of persistent gestational trophoblastic disease. Int J Gynecol Pathol 2013;32(2):199-214. PMID: 23370656

Banet N, DeScipio C, Murphy KM, Beierl K, Adams E, Vang R, Ronnett BM. Characteristics of hydatidiform moles: analysis of a prospective series with p57 immunohistochemistry and molecular genotyping. Mod Pathol 2014;27(2):238-254. PMID: 23887308

Bynum J, Murphy KM, DeScipio C, Beierl K, Adams E, Anderson D , Vang R, Ronnett BM. Invasive complete hydatidiform moles: analysis of a case series with genotyping. Int J Gynecol Pathol 2016;35(2):134-141. PMID: 2653598

Ronnett BM. Endocervical adenocarcinoma: selected diagnostic challenges. Mod Pathol 2016;29(Suppl 1):S12-28. (USCAP 2015 Long Course) PMID: 26715171

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