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Photo of Dr. Ephraim Joseph Fuchs, MD

Ephraim Joseph Fuchs, MD

Associate Professor of Oncology
Professor of Oncology
Male
Appointment Phone

410-955-8964

Primary Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

View All Locations
Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Associate Professor of Oncology
  • Professor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphoblastic Leukemia, Chronic Myeloid Leukemia, Hematologic Malignancies, Hodgkin's Disease, Leukemia, Lymphoma, Medical Oncology, Multiple Myeloma, Myelodysplastic Syndrome, Non-Hodgkin's Lymphoma

Research Interests

myeloid disorders; bone marrow transplant

Languages

  • English

Clinical Trial Keywords

  • bone marrow transplant
  • lymphoma
  • leukemia

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Pennsylvania Health System School of Medicine ( Philadelphia PA ) (1985)

    Residencies

    • The Johns Hopkins Hospital ( Baltimore MD ) (1988)

    Fellowships

    • The Johns Hopkins Hospital ( Baltimore MD ) (1994)

    Certifications

    • Internal Medicine, American Board of Internal Medicine (1988)
  • Research & Publications +

    Selected Publications

    Durakovic, N.; Bezak, K.B.; Skarica, M.; Radojcic, V.; Fuchs, E.J.; Murphy, G.F.; Luznik, L. Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions. J Immunol. 2006 Oct 1;177(7):4414-4425.

    Huff, C.A.; Fuchs, E.J.; Smith, B.D.; Blackford, A.; Garrett-Mayer, E.; Brodsky, R.A.; Flinn, I.W.; Ambinder, R.F.; Borrello, I.M.; Matsui, W.H.; Vogelsang, G.B.; Griffin, C.A.; Luznik, L.; Jones, R.J. Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions. Biol Blood Marrow Transplant. 2006 Apr;12(4):414-421.

    Ravi, R.; Fuchs, E.J.; Jain, A.; Pham, V.; Yoshimura, K.; Prouser, T.; Jalla, S.; Zhou, X.; Garrett-Mayer, E.; Kaufmann, S.H.; Schulick, R.D.; Pardoll, D.M.; Bedi, A. Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling. Cancer Res. 2006 Feb 1;66(3):1730-1739.

    Wu, K.; Giovannucci, E.; Byrne, C.; Platz, E.A.; Fuchs, C.; Willett, W.C.; Sinha, R. Meat mutagens and risk of distal colon adenoma in a cohort of U.S. men. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1120-1125.

    Bolanos-Meade, J.; Garrett-Mayer, E.; Luznik, L.; Anders, V.; Webb, J.; Fuchs, E.J.; Huff, C.A.; Matsui, W.; Borrello, I.M.; Brodsky, R.; Kasamon, Y.L.; Swinnen, L.J.; Flinn, I.W.; Ambinder, R.F.; Jones, R.J.; Hess, A.D.; Vogelsang, G.B. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant. 2007 Oct;13(10):1185-1191.

    Durakovic, N.; Radojcic, V.; Skarica, M.; Bezak, K.B.; Powell, J.D.; Fuchs, E.J.; Luznik, L. Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse. Blood. 2007 May 15;109(10):4564-4574.

    Fuchs, E.J.; Lee, L.A.; Torbenson, M.S.; Parsons, T.L.; Bakshi, R.P.; Guidos, A.M.; Wahl, R.L.; Hendrix, C.W. Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. J Infect Dis. 2007 Mar 1;195(5):703-710.

    Thimmulappa, R.K.; Fuchs, R.J.; Malhotra, D.; Scollick, C.; Traore, K.; Bream, J.H.; Trush, M.A.; Liby, K.T.; Sporn, M.B.; Kensler, T.W.; Biswal, S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal. 2007 Nov;9(11):1963-1970.

    Brodsky, R.A.; Luznik, L.; Bolanos-Meade, J.; Leffell, M.S.; Jones, R.J.; Fuchs, E.J. Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant. 2008 Oct;42(8):523-527.

    Luznik, L.; O''Donnell, P.V.; Symons, H.J.; Chen, A.R.; Leffell, M.S.; Zahurak, M.; Gooley, T.A.; Piantadosi, S.; Kaup, M.; Ambinder, R.F.; Huff, C.A.; Matsui, W.; Bolanos-Meade, J.; Borrello, I.; Powell, J.D.; Harrington, E.; Warnock, S.; Flowers, M.; Brodsky, R.A.; Sandmaier, B.M.; Storb, R.F.; Jones, R.J.; Fuchs, E.J. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008 Jun;14(6):641-650.

    Symons, H.J.; Levy, M.Y.; Wang, J.; Zhou, X.; Zhou, G.; Cohen, S.E.; Luznik, L.; Levitsky, H.I.; Fuchs, E.J. The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells. Biol Blood Marrow Transplant. 2008 May;14(5):499-509.

    Warlick, E.D.; O''Donnell, P.V.; Borowitz, M.; Grupka, N.; Decloe, L.; Garrett-Mayer, E.; Borrello, I.; Brodsky, R.; Fuchs, E.; Huff, C.A.; Luznik, L.; Matsui, W.; Ambinder, R.; Jones, R.J.; Douglas Smith, B. Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes. Leuk Res. 2008 Sep;32(9):1439-1447.

    Bolanos-Meade, J.; Luznik, L.; Muth, M.; Matsui, W.H.; Huff, C.A.; Smith, B.D.; Levy, M.Y.; Kasamon, Y.L.; Swinnen, L.J.; Powell, J.D.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen. Bone Marrow Transplant. 2009 Mar;43(6):477-480.

    Fuchs, E.J.; Huang, X.J.; Miller, J.S. HLA-haploidentical stem cell transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2009 Nov 2.

    Fuchs, E.J.; Luznik, L.; Bolanos-Meade, J.; Miller, C.B.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J. Successful pregnancy and childbirth after reduced-intensity conditioning and partially HLA-mismatched BMT. Bone Marrow Transplant. 2009 Jun;43(12):969-970.

    Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O''Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-Haploidentical BMT with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome. Biol Blood Marrow Transplant. 2009 Nov 16.

    Leffell, M.S.; Cao, K.; Coppage, M.; Hansen, J.A.; Hart, J.M.; Pereira, N.; Pereira, S.; Reinsmoen, N.L.; Senitzer, D.; Smith, A.; Torres, M.; Vega, R.; Fuchs, E. Incidence of humoral sensitization in HLA partially mismatched hematopoietic stem cell transplantation. Tissue Antigens. 2009 Oct 4;74:494-498.

    Levy, M.Y.; Sidana, A.; Chowdhury, W.H.; Solomon, S.B.; Drake, C.G.; Rodriguez, R.; Fuchs, E.J. Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation. J Pharmacol Exp Ther. 2009 Aug;330(2):596-601.

    Oster, S.F.; Ebrahimi, K.B.; Eberhart, C.G.; Schein, O.D.; Stark, W.J.; Jun, A.S. A clinicopathologic series of primary graft failure after Descemet''s stripping and automated endothelial keratoplasty. Ophthalmology. 2009 Apr;116(4):609-614.

    Wu, K.; Platz, E.A.; Willett, W.C.; Fuchs, C.S.; Selhub, J.; Rosner, B.A.; Hunter, D.J.; Giovannucci, E. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. The American journal of clinical nutrition. 2009 Dec;90(6):1623-1631.

    Bolanos-Meade, J.; Smith, B.D.; Gore, S.D.; McDevitt, M.A.; Luznik, L.; Fuchs, E.J.; Jones, R.J. 5-Azacytidine as Salvage Treatment in Relapsed Myeloid Tumors after Allogeneic Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2010 Oct 15;In Press.

    Brodsky, R.A.; Chen, A.R.; Dorr, D.; Fuchs, E.J.; Huff, C.A.; Luznik, L.; Smith, B.D.; Matsui, W.H.; Goodman, S.N.; Ambinder, R.F.; Jones, R.J. High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up. Blood. 2010 Mar 18;115(11):2136-2141.

    Chen, J.; Garner, R.C.; Lee, L.S.; Seymour, M.; Fuchs, E.J.; Hubbard, W.C.; Parsons, T.L.; Pakes, G.E.; Fletcher, C.V.; Flexner, C. Accelerator mass spectrometry measurement of intracellular concentrations of active drug metabolites in human target cells in vivo. Clin Pharmacol Ther. 2010 Dec;88(6):796-800.

    Dezern, A.E.; Luznik, L.; Fuchs, E.J.; Jones, R.J.; Brodsky, R.A. Post-transplantation cyclophosphamide for GVHD prophylaxis in severe aplastic anemia. Bone Marrow Transplant. 2010 Sep 13.

    Engler, C.; Kelliher, C.; Spitze, A.R.; Speck, C.L.; Eberhart, C.G.; Jun, A.S. Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway? Am J Ophthalmol. 2010 Feb;149(2):194-202 e192.

    Engstrom, P.F.; Arnoletti, J.P.; Benson, A.B., 3rd; Berlin, J.D.; Berry, J.M.; Chen, Y.J.; Choti, M.A.; Cooper, H.S.; Dilawari, R.A.; Early, D.S.; Enzinger, P.C.; Fakih, M.G.; Fleshman, J., Jr.; Fuchs, C.; Grem, J.L.; Knol, J.A.; Leong, L.A.; Lin, E.; Mulcahy, M.F.; Rohren, E.; Ryan, D.P.; Saltz, L.; Shibata, D.; Skibber, J.M.; Small, W.; Sofocleous, C.; Thomas, J.; Venook, A.P.; Willett, C. NCCN clinical practice guidelines in oncology. Anal carcinoma. J Natl Compr Canc Netw. 2010 Jan;8(1):106-120.

    Fuchs, E.J.; Huang, X.J.; Miller, J.S. HLA-haploidentical stem cell transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S57-63.
    Kasamon, Y.L.; Jones, R.J.; Brodsky, R.A.; Fuchs, E.J.; Matsui, W.; Luznik, L.; Powell, J.D.; Blackford, A.L.; Goodrich, A.; Gocke, C.D.; Abrams, R.A.; Ambinder, R.F.; Flinn, I.W. Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma. Ann Oncol. 2010 Jun;21(6):1203-1210.

    Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O''Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant. 2010 Apr;16(4):482-489.

    Luznik, L.; Bolanos-Meade, J.; Zahurak, M.; Chen, A.R.; Smith, B.D.; Brodsky, R.; Huff, C.A.; Borrello, I.; Matsui, W.; Powell, J.D.; Kasamon, Y.; Goodman, S.N.; Hess, A.; Levitsky, H.I.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010 Apr 22;115(16):3224-3230.

    Luznik, L.; Fuchs, E.J. High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation. Immunol Res. 2010 Jul;47(1-3):65-77.

    Luznik, L.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide for graft-versus-host disease prevention. Curr Opin Hematol. 2010 Nov;17(6):493-499.

    Petersen, G.M.; Amundadottir, L.; Fuchs, C.S.; Kraft, P.; Stolzenberg-Solomon, R.Z.; Jacobs, K.B.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gallinger, S.; Gross, M.; Helzlsouer, K.; Holly, E.A.; Jacobs, E.J.; Klein, A.P.; LaCroix, A.; Li, D.; Mandelson, M.T.; Olson, S.H.; Risch, H.A.; Zheng, W.; Albanes, D.; Bamlet, W.R.; Berg, C.D.; Boutron-Ruault, M.C.; Buring, J.E.; Bracci, P.M.; Canzian, F.; Clipp, S.; Cotterchio, M.; de Andrade, M.; Duell, E.J.; Gaziano, J.M.; Giovannucci, E.L.; Goggins, M.; Hallmans, G.; Hankinson, S.E.; Hassan, M.; Howard, B.; Hunter, D.J.; Hutchinson, A.; Jenab, M.; Kaaks, R.; Kooperberg, C.; Krogh, V.; Kurtz, R.C.; Lynch, S.M.; McWilliams, R.R.; Mendelsohn, J.B.; Michaud, D.S.; Parikh, H.; Patel, A.V.; Peeters, P.H.; Rajkovic, A.; Riboli, E.; Rodriguez, L.; Seminara, D.; Shu, X.O.; Thomas, G.; Tjonneland, A.; Tobias, G.S.; Trichopoulos, D.; Van Den Eeden, S.K.; Virtamo, J.; Wactawski-Wende, J.; Wang, Z.; Wolpin, B.M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Fraumeni, J.F., Jr.; Hoover, R.N.; Hartge, P.; Chanock, S.J. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Mar;42(3):224-228.

    Sidana, A.; Chowdhury, W.H.; Fuchs, E.J.; Rodriguez, R. Cryoimmunotherapy in urologic oncology. Urology. 2010 May;75(5):1009-1014.

    Symons, H.J.; Leffell, M.S.; Rossiter, N.D.; Zahurak, M.; Jones, R.J.; Fuchs, E.J. Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation. Biol Blood Marrow Transplant. 2010 Apr;16(4):533-542.

    Wolpin, B.M.; Kraft, P.; Xu, M.; Steplowski, E.; Olsson, M.L.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gross, M.; Helzlsouer, K.; Jacobs, E.J.; LaCroix, A.; Petersen, G.; Stolzenberg-Solomon, R.Z.; Zheng, W.; Albanes, D.; Allen, N.E.; Amundadottir, L.; Austin, M.A.; Boutron-Ruault, M.C.; Buring, J.E.; Canzian, F.; Chanock, S.J.; Gaziano, J.M.; Giovannucci, E.L.; Hallmans, G.; Hankinson, S.E.; Hoover, R.N.; Hunter, D.J.; Hutchinson, A.; Jacobs, K.B.; Kooperberg, C.; Mendelsohn, J.B.; Michaud, D.S.; Overvad, K.; Patel, A.V.; Sanchez, M.J.; Sansbury, L.; Shu, X.O.; Slimani, N.; Tobias, G.S.; Trichopoulos, D.; Vineis, P.; Visvanathan, K.; Virtamo, J.; Wactawski-Wende, J.; Watters, J.; Yu, K.; Zeleniuch-Jacquotte, A.; Hartge, P.; Fuchs, C.S. Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium. Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3140-3149.
  • Academic Affiliations & Courses +
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  • Contact & Locations +

    Locations

    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    401 N. Broadway
    Baltimore, MD 21231
    Phone: 410-955-8143
    Appointment Phone: 410-955-8964
    Fax: 410-502-8651
    Location Map

    Department/Division

    • Oncology

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