Dr. Zeitlin’s research focuses on the role of chloride channels in inherited diseases of the respiratory tract. Her particular focus is on cystic fibrosis. She has studied cystic fibrosis treatments in animal models, developed a cystic fibrosis cell line that’s now shared around the world and participated in a number of studies evaluating an array of novel treatments, including ivacaftor.
Dr. Zeitlin’s lab is studying the role of chloride channels in inherited disease of the respiratory tract. Her focus is on cystic fibrosis where she has cloned uses animal models to understand the contribution of chloride transport in developing lungs and in disease.
Learn more about research in the Pamela Zeitlin Lab.
Glycerol Phenylbutyrate Corrector Therapy For CF (GPBA)
Henry KR, Lee S, Walker D, Zeitlin PL. "Direct interactions between ENaC gamma subunit and ClCN2 in cystic fibrosis epithelial cells." Physiol Rep. 2015 Jan 27;3(1)
Kerem E, Konstan MW, De Boeck K, Accurso FJ, Sermet-Gaudelus I, Wilschanski M, Elborn JS, Melotti P, Bronsveld I, Fajac I, Malfroot A, Rosenbluth DB, Walker PA, McColley SA, Knoop C, Quattrucci S, Rietschel E, Zeitlin PL, Barth J, Elfring GL, Welch EM, Branstrom A, Spiegel RJ, Peltz SW, Ajayi T, Rowe SM; Cystic Fibrosis Ataluren Study Group. "Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial." Lancet Respir Med. 2014 Jul;2(7):539-47.
Lee S, Henderson MJ, Schiffhauer E, Despanie J, Henry K, Kang PW, Walker D, McClure ML, Wilson L, Sorscher EJ, Zeitlin PL. "Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools." Mol Cell Biol. 2014 Jul;34(14):2554-65.
Schiffhauer ES, Vij N, Kovbasnjuk O, Kang PW, Walker D, Lee S, Zeitlin PL. "Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia." Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L324-31.
Jozwik CE, Pollard HB, Srivastava M, Eidelman O, Fan Q, Darling TN, Zeitlin PL. "Antibody microarrays: analysis of cystic fibrosis." Methods Mol Biol. 2012;823:179-200.