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Pamela L Zeitlin, M.D., Ph.D.

Photo of Dr. Pamela L Zeitlin, M.D., Ph.D.

Director of Pediatric Pulmonology

Professor of Pediatrics

Female

Expertise: Cystic Fibrosis, Pediatric Pulmonary Medicine, Pulmonary Medicine

Research Interests: Cystic fibrosis, Effect of chaperons on CFTR processing, Drug development for CF

Locations

Johns Hopkins Pediatrics
Appointment Phone: 410-955-2035

200 N. Wolfe Street
Rubenstein Child Health Building
Baltimore, MD 21287 map
Phone: 410-955-2795
Fax: 410-955-1030

Background

Dr. Pamela Zeitlin is a professor of pediatrics and physiology at the Johns Hopkins University School of Medicine. Her area of clinical expertise is in pulmonary medicine, with a particular focus on cystic fibrosis. She serves as the director of pediatric pulmonology and the co-director of the Cystic Fibrosis Center at the Johns Hopkins.

Dr. Zeitlin received her M.D. and Ph.D. degrees from the Yale University School of Medicine, completed her internship and residency in pediatrics at The Johns Hopkins Hospital and her fellowship in pediatric pulmonology at Johns Hopkins University School of Medicine.

In 1988, she joined the Johns Hopkins faculty in pediatrics, where she has developed a program of clinical and translational research into cystic fibrosis. Dr. Zeitlin directs a pediatric pulmonology multidisciplinary training grant for Ph.D. and M.D. trainees interested in developing an academic career in respiratory research. She is director of the Eudowood Division of Pediatric Respiratory Sciences and deputy director of the Institute for Clinical and Translational Research at Johns Hopkins University. Her research focuses on the role of chloride channels in inherited diseases of the respiratory tract, e.g., cystic fibrosis. 

She serves on a number of National Institutes of Health Studies Sections and is a member of the American Thoracic Society.

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Titles

  • Director of Pediatric Pulmonology
  • Co-Director, Cystic Fibrosis Center
  • Director, Eudowood Division of Pediatric Respiratory Sciences
  • Professor of Pediatrics
  • Joint Appointment in Physiology

Departments / Divisions

Education

Degrees

  • MD, Yale School of Medicine (1983)

Residencies

  • Johns Hopkins University School of Medicine / Pediatrics (1986)

Fellowships

  • Johns Hopkins University School of Medicine / Pediatrics (1988)

Board Certifications

  • American Board of Pediatrics / Pediatric Pulmonology (1992, 2014)
  • American Board of Pediatrics / Pediatrics (1988)

Research & Publications

Research Summary

Dr. Zeitlin’s research focuses on the role of chloride channels in inherited diseases of the respiratory tract. Her particular focus is on cystic fibrosis.  She has studied cystic fibrosis treatments in animal models, developed a cystic fibrosis cell line that’s now shared around the world and participated in a number of studies evaluating an array of novel treatments, including ivacaftor.

Lab

Dr. Zeitlin’s lab is studying the role of chloride channels in inherited disease of the respiratory tract. Her focus is on cystic fibrosis where she has cloned uses animal models to understand the contribution of chloride transport in developing lungs and in disease. 

Learn more about research in the Pamela Zeitlin Lab.

Clinical Trials

Glycerol Phenylbutyrate Corrector Therapy For CF (GPBA)

Selected Publications

View all on Pubmed

Henry KR, Lee S, Walker D, Zeitlin PL. "Direct interactions between ENaC gamma subunit and ClCN2 in cystic fibrosis epithelial cells." Physiol Rep. 2015 Jan 27;3(1)

Kerem E, Konstan MW, De Boeck K, Accurso FJ, Sermet-Gaudelus I, Wilschanski M, Elborn JS, Melotti P, Bronsveld I, Fajac I, Malfroot A, Rosenbluth DB, Walker PA, McColley SA, Knoop C, Quattrucci S, Rietschel E, Zeitlin PL, Barth J, Elfring GL, Welch EM, Branstrom A, Spiegel RJ, Peltz SW, Ajayi T, Rowe SM; Cystic Fibrosis Ataluren Study Group. "Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial." Lancet Respir Med. 2014 Jul;2(7):539-47.

Lee S, Henderson MJ, Schiffhauer E, Despanie J, Henry K, Kang PW, Walker D, McClure ML, Wilson L, Sorscher EJ, Zeitlin PL. "Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools." Mol Cell Biol. 2014 Jul;34(14):2554-65.

Schiffhauer ES, Vij N, Kovbasnjuk O, Kang PW, Walker D, Lee S, Zeitlin PL. "Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia." Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L324-31.

Jozwik CE, Pollard HB, Srivastava M, Eidelman O, Fan Q, Darling TN, Zeitlin PL. "Antibody microarrays: analysis of cystic fibrosis." Methods Mol Biol. 2012;823:179-200.

Activities & Honors

Honors

  • Elizabeth A. Rich, M.D. Award, American Thoracic Society, 2012

Memberships

  • American Thoracic Society
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