Skip Navigation
Find a Doctor
 
 
 
 

 

Photo of Dr. Daniel Nyhan, MD

Daniel Nyhan, MD

Director of Cardiac Anesthesia Division
Professor of Anesthesiology and Critical Care Medicine
Male
Appointment Phone

410-955-7519

Main Location

The Johns Hopkins Hospital

View All Locations
Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Director of Cardiac Anesthesia Division
  • Executive Vice Chairman, ACCM, The Johns Hopkins University School of Medicine
  • Professor of Anesthesiology and Critical Care Medicine
  • Associate Professor of Surgery

Expertise

Anesthesiology

Research Interests

Vascular Aging, Underlying Mechanisms

Languages

  • English

Memberships

American Society of Anesthesiologists
American Heart Association
Membership of the Royal College of Physicians of Ireland

Additional Resources

Additional Resources +
  • Education +

    Training

    • Faculty Of MedicineNational University ( Cork ) (1979)

    Residencies

    • Johns Hopkins University School of Medicine / Anesthesiology and Critical Care Medicine ( Baltimore MD) (1985)

    Certifications

    • American Board of Anesthesiology / Anesthesiology (1986)
  • Research & Publications +

    Selected Publications

    Publications Since 2006

    1. White AR, Ryoo SW, Li D, Champion HC, Steppan J, Wang D, Nyhan D, Shoukas AA, Hare JM, Berkowitz DE. Knockdown of arginase 1 restores NO signaling in the vasculature of old rats. Hypertension 2006; 47:245-251.

    2. Gao WD, Da T, Nyhan D. Increased cross-bridge cycling rate in stunned myocardium. Am J Physiol Heart Circ Physiol 2006;290:H866-H893.

    3. Steppan J, Ryoo S, Schuleri KH, Gregg C, Hasan RK, White AR, Bugaj LJ, Khan M, Santhanam L, Nyhan D, Shoukas A, Hare J, Berkowitz DE. Arginase modulates myocardial contractility by a nitric oxide synthase-1 dependent mechanism. PNAS USA. 2006;103:4759-4764.

    4. Ryoo S, Lemmon C, Soucy KG, Gupta G, White AR, Nyhan D, Shoukas A, Romer LH, Berkowitz DE. Oxidized low-density lipoprotein-dependent endothelial arginase Hi activation contributes to impaired nitric oxide signaling. Circ Res. 2006;99: 951-960.

    5. Soucy KG, Ryoo S, Benjo A, Lim HK, Gupta G, Sohi JS, Elser J, Aon MA, Nyhan D, Shoukas AA, Berkowitz DE. Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffeness. JAppI Physiol 2006;101:1751-1759.

    6. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE. Mitochondrial arginase II constrains endothelial NOS-3 activity. AJP-Heart, Lung, Physiol. 2007;93:H3317-H3324.

    7. Berkowitz DE, Nyhan D. Critical role of the alpha-1 B adrenoreceptors in sympathetically-mediated pressor and contractile responses to hypotension. Circulation. In Review.

    8. Benjo A, Thompson RE, Fine D, Hogue CW, Alejo D, Kaw A, Gerstenblith G, Shah A, Berkowitz DE, Nyhan D. Pulse pressure predicts stroke development and acute renal failure after cardiac surgery. Hypertension. 2007;50:630-635.

    9a. Tuday EC, Meek JV, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity-induced changes in aortic
    stiffness and their role in orthostatic intolerance, J Appl Physiol, 2007;102:853-858.

    9b. Associated Editorial: to be published in J Appl Physiol 2007;103:1-2.

    10. Santhanam L, Lim HK, Lim HK, Miriel V, Brown T, Patel M, Balanson S, Ryoo S, Anderson M, Irani K, Khanday F, Di Costanzo L, Nyhan D, Hare JM, Christianson DW, Rivers R, Shoukas A, Berkowitz DE. Inducible NO synthase dependent S-nitrosylation and activation of arginasel contributes to age-related endothelial dysfunction. Circ Res. 2007;101:692-702.

    11. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE. Mitochondrial arginase II constrains endothelial NOS-3 activity. AJP - Heart, Circ Physiol. 2007;293:H3317-H3324.

    12. Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, tuday E, Baraban E, Hies M, Gerstenblith G, Nyhan D, Shoukas A, Christianson DW, Alp NJ, Champion HC, Huso D, Berkowitz DE. Endothelial arginase II: a novel target for the treatment of atherosclerosis, Circ Res. Circ Res. 2008;102:923-943.

    13. Tuday EC, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity induced changes in aortic stiffness and its role in orthostatic intolerance, J Appl Physiol, 2007;102:853-858.

    14. Nyhan D, Berkowitz DE. Perioperative blood pressure management: does central vascular stiffness matter? Anesth Analg. 2008;107:1103-1106.

    Chapters and Reviews since 2006

    1. Grogan K, Nyhan D, Berkowitz DE. Pharmacology of anesthetic drugs. IN: Cardiac Anesthesia; 5th Edition. JA Kaplan, D Reich, S Konstade, C Lake, eds. Elsevier/Saunders, New York, 2006. Chap 9, pp 165-212.

    2. Nyhan D, BlanckTJJ. Cardiac physiology. IN: Mechanisms of Anesthetic Action, 2nd Edition. IN: Basic and Applied Science for Anesthesia. HC Hemmings, Jr., PM Hopkins, eds. CV Mosby, London; Chapter 39.

    3. Steppan J, Berkowitz DE, Martinez E, Nyhan D. Diastolic heart function and the elderly. IN: Aging and Anesthesia. F Sieber, ed. McGraw-Hill, Philadelphia, Chapter 16, 2006.

    4. Simmonds P, Nyhan D, Berkowitz DE. Cardiovascular pharmacological agents. IN: The Johns Hopkins Manual of Cardiac Surgical Care, 2nd Edition. Eds. JV Conte, WA Baumgartner, SG Owens, T Dorman. Elsevier, Philadelphia, PA. Chapter 2, 2008.

    5. Dorman T, Nyhan D. Postoperative hemodynamic management. IN: The Johns Hopkins Manual of Cardiac Surgical Care, 2nd Edition. Eds. JV Conte, WA Baumgartner, SG Owens, T Dorman. Elsevier, Philadelphia, PA. Chapter 9, 2008.

    6. Grogan K, Nyhan D, Berkowitz D. Pharmacology of anesthetic drugs. IN: Cardiac Anesthesia, &h Edition. JA Kaplan, D Reich, S Konstade, C Lake, eds. Elsevier/Saunders, New York. Chapter 7, 2008.



  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Tower 711
    Baltimore, MD 21287
    Phone: 410-955-7519
    Appointment Phone: 410-955-7519
    Fax: 410-955-0994
    Location Map

    Department/Division

    • Anesthesiology and Critical Care Medicine - Cardiac Anesthesia

Is This You? Edit Profile

 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer