Skip Navigation
Search Menu
Find an Expert

 

Photo of Dr. Mark Donowitz

Mark Donowitz, M.D.

Mark Donowitz, M.D.
Director, Hopkins NIH/NIDDK Conte Core Center
Professor of Medicine

Male

Appointment Phone

410-933-7495

Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Director, Hopkins NIH/NIDDK Conte Core Center
  • GI Division, Director of Basic Research
  • Professor of Medicine
  • Professor of Physiology

Centers & Institutes

Departments

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-933-7495

600 N. Wolfe Street
Ross Research Building Suite 925
Baltimore, MD 21287 map
Phone: 410-955-9675
Fax: 410-955-9677

Expertise

Celiac Disease, Clinical Gastroenterology, Diarrheal Disease, Digestive Diseases, Gastroenterology, Inflammatory Bowel Disease, Short Bowel Syndrome

Research Interests

Intestinal Salt Absorption and the proteins involved including their regulation; Development of drug therapy for diarrheal disorders; Use of human enteroids to understand intestinal physiology and pathophysiology

Biography

Mark Donowitz, M.D . has had a distinguished career of scientific discovery, mentorship of young researchers and advocacy for the gastroenterology specialty. Dr. Donowitz is LeBoff Professor of Medicine and Professor of Physiology, Director of the Hopkins Center for Epithelial Disorders at The Johns Hopkins University School of Medicine, and is Founding Director of the NIH/NIDDK Hopkins Conte Digestive Diseases Center for Basic and Translational Research. He was President of the American Gastroenterological Association 2006-2007. He also served as President of the Gastroenterology-Research Group. He has received the Distinguished Achievement Award and as well as the Davenport Memorial Prize from the American Physiology Society, and is a Fellow of the American Association for the Advancement of Science.
 
His scientific focus has been to understand regulation of intestinal Na absorption in normal digestive physiology and abnormalities that contribute to diarrheal diseases. His group was the first to recognize the mammalian Na/H exchanger gene family, to clone the epithelial isoforms, and to trace the evolutionary development of the gene family. He has examined structure/function aspects of the exchangers and identified the large, multiprotein complexes in which the epithelial NHEs function. In addition, his group identified a gene family of PDZ containing brush border proteins called the NHERF family which are scaffolding proteins which interact with NHE3 and are involved in forming the multiprotein complexes, are critical for its regulation, and take part in its association with the cytoskeleton.
 
He has pioneered use of human mini-intestines made from normal human subjects to advance understanding of human digestive physiology and pathophysiology especially related to host-pathogen interactions.
 
His clinical interests are in diagnosis and management of chronic diarrheal diseases, including short gut syndrome, inflammatory bowel diseases and celiac disease.
 
 

...read more

    Additional Information

  • Education +

    Degrees

    • Johns Hopkins University School of Medicine (1968)

    Certifications

    • American Board of Internal Medicine / Gastroenterology (1975)
    • American Board of Internal Medicine / Internal Medicine (1972)
  • Research & Publications +
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Memberships

    • AAAS
    • AAP
    • American Gastroenterogical Association
    • American Physiological Society
    • ASCI
    • Interurban Clinical Club

    Professional Activities

    • President, Gastoenterology Research Group
    • President, Interurban Clinical Club
    • President , American Gastroenterological Association, 2006 - 2007
  • Videos & Media +
Is This You? Edit Profile