Lab Website: Tomaselli Lab
Clinical Trial Keywords:
sudden death, implantable defibrillator, arrhythmia, PROSE-ICD
Donald M. Lloyd-Jones; Yuling Hong; Darwin Labarthe; Dariush Mozaffarian; Lawrence J. Appel; Linda Van Horn; Kurt Greenlund; Stephen Daniels; Graham Nichol; Gordon F. Tomaselli; et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: The american heart association's strategic impact goal through 2020 and beyond. Circulation. 2010;121(4):586-613.
Gordon F. Tomaselli; Eduardo Marbán. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovascular Research. 1999;42(2):270-283.
Stefan Kääb; H. Bradley Nuss; Nipavan Chiamvimonvat; Brian O'Rourke; Peter H. Pak; David A. Kass; Eduardo Marban; Gordon F. Tomaselli. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circulation Research. 1996;78(2):262-273.
Ronald D. Berger; Edward K. Kasper; Kenneth L. Baughman; Eduardo Marban; Hugh Calkins; Gordon F. Tomaselli. Beat-to-beat QT interval variability: Novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation.  1997;96(5):1557-1565.
Brian O'Rourke; David A. Kass; Gordon F. Tomaselli; Stefan Kääb; Richard Tunin; Eduardo Marbán. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: Experimental studies. Circulation Research. 1999;84(5):562-570.
André Schmidt; Clerio F. Azevedo; Alan Cheng; Sandeep N. Gupta; David A. Bluemke; Thomas K. Foo; Gary Gerstenblith; Robert G. Weiss; Eduardo Marbán; Gordon F. Tomaselli; et al. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation. 2007;115(15):2006-2014.
Tian Xue; Hee Cheol Cho; Fadi G. Akar; Suk-Ying Tsang; Steven P. Jones; Eduardo Marbán; Gordon F. Tomaselli; Ronald A. Li. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation. 2005;111(1):11-20.
Carina Blomström-Lundqvist; Melvin M. Scheinman; Etienne M. Aliot; Joseph S. Alpert; Hugh Calkins; A. John Camm; W. Barton Campbell; David E. Haines; Karl H. Kuck; Bruce B. Lerman; et al. ACC/AHA/ESC Guidelines for the Management of Patients with Supraventricular Arrhythmias - Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients with Supraventricular Arrhythmias). Journal of the American College of Cardiology. 2003;42(8):1493-1531.
Gordon F. Tomaselli; Dirk J. Beuckelmann; Hugh G. Calkins; Ronald D. Berger; Paul D. Kessler; John H. Lawrence; David Kass; Arthur M. Feldman; Eduardo Marban. Sudden cardiac death in heart failure: The role of abnormal repolarization. Circulation. 1994;90(5):2534-2539.
Carina Blomström-Lundqvist; Melvin M. Scheinman; Etienne M. Aliot; Joseph S. Alpert; Hugh Calkins; A. John Camm; W. Barton Campbell; David E. Haines; Karl H. Kuck; Bruce B. Lerman; et al. ACC/AHA/ESC Guidelines for the Management of Patients With Supraventricular Arrhythmias - Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias). Circulation. 2003;108(15):1871-1909.
Customizing stem cell-derived cardiomyocytes for transplantation
Patent # WO2006017567 A3 | 08/02/2004
The present invention relates to methods of customizing the biological activity (e.g. rhythmic firing rate) of cardiomyocytes derived from pluripotent or multipotent stem cells, followed by transplantation to modify cardiac functions in vivo (e.g. to augment or attenuate the heart rate by modifying the cellular excitability of recipient cells).
Treatment of ischemia-induced arrhythmias
Patent # WO2006138487 A3 | 06/14/2005
New methods and compositions are provided for preventing development of arrhythmias associated with ischemia and repurfusion. Preferred methods of the invention include treatment to inhibit the mitochondrial inner membrane anion channel.
Methods for improving heart function
Patent # Methods for improving heart function | 11/08/2010
The invention provides methods related to improving heart function.
Ventricular activation (rr) entropy change as a predictor of sudden cardiac death in cardiac resynchronization therapy patients
Patent # WO2013170232 A1 | 05/11/2012
A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a cardiac entropy in the RR time series over the temporal intervals using coefficient of sample entropy (COSEn). Additionally, the method includes comparing the cardiac entropy between the intervals to determine health and mortality. The absolute and relative changes in entropy over a patient's follow up period provide dynamic information regarding health and mortality risk. The determination of health and mortality can then be used to create a treatment plan for the subject.
System and method for risk stratification based on dynamic nonlinear analysis and comparison of cardiac repolarization with other physiological signals
Patent # WO2013170251 A2 | 05/11/2012
System and Method for Risk Stratification Based on Dynamic Nonlinear Analysis and Comparison of Cardiac Repolarization with Other Physiological Signals