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Francis Michael Giardiello, M.D.

Photo of Dr. Francis Michael Giardiello, M.D.

Professor of Medicine


Expertise: Clinical Gastroenterology, Colon Cancer, Colon Polyps, Digestive Diseases, Family History of Cancer, Gastroenterology, Gastrointestinal Cancers, Rectal Bleeding more

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The Johns Hopkins Hospital
Appointment Phone: 410-583-2888

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-583-2888


Dr. Giardiello was graduated from Tufts University School of Medicine and has a MBA from Johns Hopkins University. He received his internal medicine training at The University of Michigan and fellowship training in Gastroenterology at The Johns Hopkins Hospital. Presently, he is the Johns G. Rangos, Sr. Professor of Medicine, the program director for the gastrointestinal fellowship and directs the Johns Hopkins Colorectal Cancer Registry and Risk Assessment Clinic. He served for 9 years as the Director of the Division of Gastroenterology at Johns Hopkins University.

Dr. Giardiellos clinical and research interests have focused on the study of cancer and cancer chemoprevention in the gastrointestinal tract. This has included the investigation of the genetic basis of familial colorectal cancer and the use of genetic testing in the hereditary forms of colorectal cancer. He has a continuing interest in the study of the genotypic phenotypic correlations in the polyposis syndromes which include familial adenomatous polyposis, juvenile polyposis and Peutz-Jeghers syndrome. more


  • Professor of Medicine
  • Professor of Oncology
  • Professor of Pathology



  • MD, Tufts University School of Medicine (1980)


  • University of Michigan Health System / Internal Medicine (1983)


  • Johns Hopkins University School of Medicine / Gastroenterology (1985)
  • Johns Hopkins University School of Medicine / Gastroenterology (1986)

Board Certifications

  • American Board of Internal Medicine / Gastroenterology (1985)
  • American Board of Internal Medicine / Internal Medicine (1983)

Research & Publications

Selected Publications

Canto, M.I.; Goggins, M.; Hruban, R.H.; Petersen, G.M.; Giardiello, F.M.; Yeo, C.; Fishman, E.K.; Brune, K.; Axilbund, J.; Griffin, C.; Ali, S.; Richman, J.; Jagannath, S.; Kantsevoy, S.V.; Kalloo, A.N. Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study. Clin Gastroenterol Hepatol. 2006 Jun;4(6):766-781; quiz 665.

Chen, S.; Wang, W.; Lee, S.; Nafa, K.; Lee, J.; Romans, K.; Watson, P.; Gruber, S.B.; Euhus, D.; Kinzler, K.W.; Jass, J.; Gallinger, S.; Lindor, N.M.; Casey, G.; Ellis, N.; Giardiello, F.M.; Offit, K.; Parmigiani, G. Prediction of germline mutations and cancer risk in the Lynch syndrome. Jama. 2006 Sep 27;296(12):1479-1487.

Hearle, N.; Schumacher, V.; Menko, F.H.; Olschwang, S.; Boardman, L.A.; Gille, J.J.; Keller, J.J.; Westerman, A.M.; Scott, R.J.; Lim, W.; Trimbath, J.D.; Giardiello, F.M.; Gruber, S.B.; Offerhaus, G.J.; Rooij, F.W.; Wilson, J.H.; Hansmann, A.; Moslein, G.; Royer-Pokora, B.; Vogel, T.; Phillips, R.K.; Spigelman, A.D.; Houlston, R.S. STK11 status and intussusception risk in Peutz-Jeghers syndrome. Journal of medical genetics. 2006 Aug;43(8):e41.

Levin, B.; Barthel, J.S.; Burt, R.W.; David, D.S.; Ford, J.M.; Giardiello, F.M.; Gruber, S.B.; Halverson, A.L.; Hamilton, S.; Kohlmann, W.; Ludwig, K.A.; Lynch, P.M.; Marino, C.; Martin, E.W., Jr.; Mayer, R.J.; Pasche, B.; Pirruccello, S.J.; Rajput, A.; Rao, M.S.; Shike, M.; Steinbach, G.; Terdiman, J.P.; Weinberg, D.; Winawer, S.J. Colorectal Cancer Screening Clinical Practice Guidelines. J Natl Compr Canc Netw. 2006 Apr;4(4):384-420.

Brim, H.; Mokarram, P.; Naghibalhossaini, F.; Saberi-Firoozi, M.; Al-Mandhari, M.; Al-Mawaly, K.; Al-Mjeni, R.; Al-Sayegh, A.; Raeburn, S.; Lee, E.; Giardiello, F.; Smoot, D.T.; Vilkin, A.; Boland, C.R.; Goel, A.; Hafezi, M.; Nouraie, M.; Ashktorab, H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008;7:68.

Cho, N.L.; Redston, M.; Zauber, A.G.; Carothers, A.M.; Hornick, J.; Wilton, A.; Sontag, S.; Nishioka, N.; Giardiello, F.M.; Saltzman, J.R.; Gostout, C.; Eagle, C.J.; Hawk, E.T.; Bertagnolli, M.M. Aberrant crypt foci in the adenoma prevention with celecoxib trial. Cancer prevention research (Philadelphia, Pa. 2008 Jun;1(1):21-31.

Cruz-Correa, M.; Zhao, R.; Oviedo, M.; Bernabe, R.D.; Lacourt, M.; Cardona, A.; Lopez-Enriquez, R.; Wexner, S.; Cuffari, C.; Hylind, L.; Platz, E.; Cui, H.; Feinberg, A.P.; Giardiello, F.M. Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene. Epigenetics. 2009 Feb;4(2):114-118.

Edelstein, D.L.; Axilbund, J.; Baxter, M.; Hylind, L.M.; Romans, K.; Griffin, C.A.; Cruz-Correa, M.; Giardiello, F.M. Rapid Development of Colorectal Neoplasia in Patients With Lynch Syndrome. Clin Gastroenterol Hepatol. 2010 Nov 9.

Langeveld, D.; van Hattem, W.A.; de Leng, W.W.; Morsink, F.H.; Ten Kate, F.J.; Giardiello, F.M.; Offerhaus, G.J.; Brosens, L.A. SMAD4 immunohistochemistry reflects genetic status in juvenile polyposis syndrome. Clin Cancer Res. 2010 Aug 15;16(16):4126-4134.
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