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Adrian Sandra Dobs, M.D., M.P.H.

Photo of Dr. Adrian Sandra Dobs, M.D., M.P.H.

Director, Johns Hopkins Clinical Research Network

Professor of Medicine

Female

Expertise: Diabetes Mellitus, Endocrinology , HIV-Associated Metabolic Abnormalities, Hyperlipidemia, Male Testosterone Disorders, Polycystic Ovarian Disease, Sex Hormone Disorders ...read more

Research Interests: Endocrinology, Gonadal dysfunction, hyperlipidemia, diabetes mellitus

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-9270

600 N. Wolfe Street
Sheikh Zayed Tower Suite 328
Baltimore, MD 21287 map
Phone: 410-502-6888
Fax: 410-367-2042

Contact for Research Inquiries

Phone: 443-287-4000

Background

Dr. Dobs is presently an active investigator in the field of male gonadal function. She is particularly interested in new forms of male hormone replacement therapy and has published extensively in the area of hormonal changes with aging. her clinical practice focused on sex hormone disorders in both men and women. As Director of the Clinical Trials Unit, she oversees a team of individuals dedicated to facilitating clinical research within an academic medical center environment.Her other administrative roles include Director of the Johns Hopkins SYSU (China) Collaboration in Clinical Research and Director of the NCI-funded Center to Reduce Cancer Disparities. 

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Titles

  • Director, Johns Hopkins Clinical Research Network
  • Director, Johns Hopkins - SYSU (China) Collaboration
  • Director - Johns Hopkins Center to Reduce Cancer Disparities
  • Professor of Medicine
  • Professor of Oncology

Education

Degrees

  • MD, Albany Medical College of Union University (1978)

Board Certifications

  • American Board of Internal Medicine / Endocrinology and Metabolism (1987)
  • American Board of Internal Medicine / Internal Medicine (1981)

Research & Publications

Research Summary

Dr. Dobs is presently an active investigator in the field of sex hormone disorders and a clinical investigator who has published extensively in HIV-related endocrinopathies and risks and benefits of testosterone replacement therapies.

Lab Website: Adrian Dobs Lab
Core Facility: Johns Hopkins Clinical Research Network (JHCRN)

Clinical Trial Keywords

Hormone replacement therapy men and women, hyperlipidemia, diabetes

Selected Publications

Research Support.

Ongoing Research Support:
RO1 DA1409801 (Dobs AS) 06/15/03 05/31/09
NIDA/NIH Cognitive Consequences of Endocrine Dysfunction in Injection Drug Users
Role: Principal Investigator
The major goal of this project is to investigate the consequences of hypogonadal endocrine dysfunction in injection drug users with and without HIV.

2U01 AI35042-07 (Margolick JB) 04/01/04 03/31/11
NIAID/NIH Multi-Center AIDS Cohorts
Role: Co-Investigator
The major goal of this project is to determine metabolic abnormalities of HIV disease.

R03DA026038 09/30/08 9/29/10
Serum Sex Hormones and Cardiovascular Risk in the MACS
The major goal of this project is to study the relationship of sex steroids to heart disease
Principal Investigator

Publications

1. Paller CJ, Shiels MS,Rohrmann S, Basaria S, Rifai N, Nelson W, Platz EA, Dobs A, Relationship of Sex Streriod Hormones with Bone Mineral Density in a Nationally-Representative Sample of Men, Clin Endocrinol (Oxf) May 2008 (E-pub ahead of print) PMID 18485120

2. Wohl D, Scherzer R, Heymensfield S, Simberkoff M, Sidney S, Bacchetti P, Grunfeld C:FRAM Study Investigators (including Dobs A), The Associations of Regional Adipose Tissue with Lipid and Lipoprotein Levels in HIV Infected Men, J Aquir Immune Defic Syndr. , May 2008 48 (1):44-52.

3. Brown T, Jacobson L, Xu X, Tang Y, Qaqish R, Kingsley L, Palella F, Witt M, Visscher B, Dobs A, The Relationship Between Inflammatory Markers, the Metabolic Syndrome and Body Composition Among HIV Seropositive and Seronegative Men: Two Nested Case-Control Studies from the Multicenter AIDS Cohort Study, Conference on Retroviruses and Oppurtunistic Infections.

4. Dobs A, Mortgentaler A, Does Testosterone Therapy Increase the Risk of Prostate Cancer?Endocr.Prac.,2008,14,7,904-911 PMID 18996823
Eckman A, Dobs A, Drug-Induced Gynecomastia,Expert Opin.Drug Saf..,2008,7,6,691-702, England PMID 18983216

5. Mortgentaler A, Dobs AS, Kaufman JM, Miner MM, Shsbsigh R, Swerdloff, RS, Wang C. Long Acting Testosterone Therapyin Men with Hypogonadism: Results of a Pharmacokinetic Clinical Study, JUrol.,2008,180,6,2307-2313,United States, PMID 18930255

6. Ouyang P, Vaidya D, Dobs A, Golden S, Szklo M, Heckbert S, Kopp P, Gapstur S, Sex Hormone Levels and Subclinical Atherosclerosis , Atherosclerosis, 2008 PMID 18849030

7. Andrade A, Hendrix C, Parsons T, Caballero B, Yuan C, Flexner C, Dobs A, Brown T, BMC Complementary and Alternative Medicine.,2008,8,50,England, PMID 18713456

8. Vaidya D, Dobs A, Gapstur S, Golden S, Hankinson A, Liu K, Ouyang P, The Association of Endogenous Sex Hormones with Lipoprotein Subfraction Profile in the Multi-Ethnic Study of Atheroschlerosis, Metabolism, 2008,57,6,782-790, United States, PMID 18502260

9. Pfeil E., Dobs A, Current and Future Testosterone Delivery Systems for Treatment of the Hypogonadal Male, Expert Opin. Drug Deliv., 2008 5,4,471-481, England, PMID 18426387

10. Cofrancesco J, Scherzer R, Tien P, Gilbert C, Southwell H, Sidney S, Dobs A, Grunfeld C, Illicit Drug Use and HIV Treatment Outcomes in a US Cohort, AIDS,2008,22,3,357-365, England, PMID 18195562

Journal Citations

Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. Cancer. 2006 Feb 1;106(3):581-588.

Braga-Basaria, M.; Dobs, A.S.; Muller, D.C.; Carducci, M.A.; John, M.; Egan, J.; Basaria, S. Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol. 2006 Aug 20;24(24):3979-3983.

Braga-Basaria, M.; Muller, D.C.; Carducci, M.A.; Dobs, A.S.; Basaria, S. Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy. International journal of impotence research. 2006 Sep-Oct;18(5):494-498.

Levinson, N.M.; Kuchment, O.; Shen, K.; Young, M.A.; Koldobskiy, M.; Karplus, M.; Cole, P.A.; Kuriyan, J. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol. 2006 May;4(5):e144.

Maggio, M.; Blackford, A.; Taub, D.; Carducci, M.; Ble, A.; Metter, E.J.; Braga-Basaria, M.; Dobs, A.; Basaria, S. Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. J Androl. 2006 Nov-Dec;27(6):725-728.

Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancer. Archives of internal medicine. 2007 Mar 26;167(6):612-613.

Rohrmann, S.; Nelson, W.G.; Rifai, N.; Brown, T.R.; Dobs, A.; Kanarek, N.; Yager, J.D.; Platz, E.A. Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. J Clin Endocrinol Metab. 2007 Jul;92(7):2519-2525.

Selvin, E.; Feinleib, M.; Zhang, L.; Rohrmann, S.; Rifai, N.; Nelson, W.G.; Dobs, A.; Basaria, S.; Golden, S.H.; Platz, E.A. Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007 Feb;30(2):234-238.

Paller, C.J.; Shiels, M.S.; Rohrmann, S.; Basaria, S.; Rifai, N.; Nelson, W.; Platz, E.A.; Dobs, A. Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men. Clinical endocrinology. 2009 Jan;70(1):26-34.

Sharma, P.; Wisniewski, A.; Braga-Basaria, M.; Xu, X.; Yep, M.; Denmeade, S.; Dobs, A.S.; DeWeese, T.; Carducci, M.; Basaria, S. Lack of an effect of high dose isoflavones in men with prostate cancer undergoing androgen deprivation therapy. J Urol. 2009 Nov;182(5):2265-2272.

Shiels, M.S.; Rohrmann, S.; Menke, A.; Selvin, E.; Crespo, C.J.; Rifai, N.; Dobs, A.; Feinleib, M.; Guallar, E.; Platz, E.A. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes Control. 2009 Aug;20(6):877-886.

Menke, A.; Guallar, E.; Rohrmann, S.; Nelson, W.G.; Rifai, N.; Kanarek, N.; Feinleib, M.; Michos, E.D.; Dobs, A.; Platz, E.A. Sex steroid hormone concentrations and risk of death in US men. Am J Epidemiol. 2010 Mar 1;171(5):583-592.

Mondul, A.M.; Selvin, E.; Rohrmann, S.; Menke, A.; Feinleib, M.; Kanarek, N.; Rifai, N.; Dobs, A.S.; Platz, E.A. Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III. Cancer Causes Control. 2010 Oct;21(10):1575-1583.

Activities & Honors

Memberships

  • American Andrology Society, 1994
  • Institute of Medicine Roundtable in Clinical Research, 2000
  • The Endocrine Society, 1987

Professional Activities

  • Director, Clinical Trials Unit of Johns Hopkins School of Medicine, 1998
  • Director, Johns Hopkins Center for Complementary and Alternative Medicine , 2001 - 2007
  • Director, NCI-funded Center to Reduce Cancer Disparities, 2012
  • Director , JHU-SYSU (China) Clinical Reserach Collaboration, 2011
  • Medical Residency, Albert Einstein College of Medicine, 1978 - 1981
    Internal Medicine
  • Vice-Chair , Johns Hopkins University School of Medicine, 1996 - 2001
    Department of Medicine Clinical Research
  • Vice-Chair , Johns Hopkins University School of Medicine, 2001
    Department of Medicine Faculty Development
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