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Adrian Sandra Dobs, M.D.

Director, Johns Hopkins Clinical Research Network
Professor of Medicine

Female

Appointment Phone

410-955-9270

Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Johns Hopkins Clinical Research Network
  • Director, Johns Hopkins - SYSU (China) Collaboration
  • Vice-Chair Department of Medicine for Faculty Development
  • Director - Johns Hopkins Center to Reduce Cancer Disparities
  • Professor of Medicine
  • Professor of Oncology

Centers & Institutes

Departments

  • Medicine - Endocrinology
  • Medicine - Endocrinology, Diabetes and Metabolism
  • Oncology

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-955-9270

600 N. Wolfe Street
Sheikh Zayed Tower Suite 328
Baltimore, MD 21287 map
Phone: 410-502-6888
Fax: 410-367-2042

The Johns Hopkins Hospital

600 N. Wolfe Street
Halstead
Baltimore, MD 21287 map

Contact for Research Inquiries

Phone: 443-287-4000

Expertise

Diabetes Mellitus, Endocrinology , HIV-Associated Metabolic Abnormalities, Hyperlipidemia, Male Testosterone Disorders, Polycystic Ovarian Disease, Sex Hormone Disorders

Research Interests

Endocrinology, Gonadal dysfunction, hyperlipidemia, diabetes mellitus

Biography

Dr. Dobs is presently an active investigator in the field of male gonadal function. She is particularly interested in new forms of male hormone replacement therapy and has published extensively in the area of hormonal changes with aging. her clinical practice focused on sex hormone disorders in both men and women. As Director of the Clinical Trials Unit, she oversees a team of individuals dedicated to facilitating clinical research within an academic medical center environment.Her other administrative roles include Director of the Johns Hopkins SYSU (China) Collaboration in Clinical Research and Director of the NCI-funded Center to Reduce Cancer Disparities. 

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    Additional Information

  • Education +

    Degrees

    • Albany Medical College of Union University / MD (1978)

    Certifications

    • American Board of Internal Medicine / Endocrinology and Metabolism (1987)
    • American Board of Internal Medicine / Internal Medicine (1981)
  • Research & Publications +

    Research Summary

    Dr. Dobs is presently an active investigator in the field of sex hormone disorders and a clinical investigator who has published extensively in HIV-related endocrinopathies and risks and benefits of testosterone replacement therapies.

    Clinical Trial Keywords: Hormone replacement therapy men and women, hyperlipidemia, diabetes

    Selected Publications

    Research Support.

    Ongoing Research Support:
    RO1 DA1409801 (Dobs AS) 06/15/03 05/31/09
    NIDA/NIH Cognitive Consequences of Endocrine Dysfunction in Injection Drug Users
    Role: Principal Investigator
    The major goal of this project is to investigate the consequences of hypogonadal endocrine dysfunction in injection drug users with and without HIV.

    2U01 AI35042-07 (Margolick JB) 04/01/04 03/31/11
    NIAID/NIH Multi-Center AIDS Cohorts
    Role: Co-Investigator
    The major goal of this project is to determine metabolic abnormalities of HIV disease.

    R03DA026038 09/30/08 9/29/10
    Serum Sex Hormones and Cardiovascular Risk in the MACS
    The major goal of this project is to study the relationship of sex steroids to heart disease
    Principal Investigator

    Publications

    1. Paller CJ, Shiels MS,Rohrmann S, Basaria S, Rifai N, Nelson W, Platz EA, Dobs A, Relationship of Sex Streriod Hormones with Bone Mineral Density in a Nationally-Representative Sample of Men, Clin Endocrinol (Oxf) May 2008 (E-pub ahead of print) PMID 18485120

    2. Wohl D, Scherzer R, Heymensfield S, Simberkoff M, Sidney S, Bacchetti P, Grunfeld C:FRAM Study Investigators (including Dobs A), The Associations of Regional Adipose Tissue with Lipid and Lipoprotein Levels in HIV Infected Men, J Aquir Immune Defic Syndr. , May 2008 48 (1):44-52.

    3. Brown T, Jacobson L, Xu X, Tang Y, Qaqish R, Kingsley L, Palella F, Witt M, Visscher B, Dobs A, The Relationship Between Inflammatory Markers, the Metabolic Syndrome and Body Composition Among HIV Seropositive and Seronegative Men: Two Nested Case-Control Studies from the Multicenter AIDS Cohort Study, Conference on Retroviruses and Oppurtunistic Infections.

    4. Dobs A, Mortgentaler A, Does Testosterone Therapy Increase the Risk of Prostate Cancer?Endocr.Prac.,2008,14,7,904-911 PMID 18996823
    Eckman A, Dobs A, Drug-Induced Gynecomastia,Expert Opin.Drug Saf..,2008,7,6,691-702, England PMID 18983216

    5. Mortgentaler A, Dobs AS, Kaufman JM, Miner MM, Shsbsigh R, Swerdloff, RS, Wang C. Long Acting Testosterone Therapyin Men with Hypogonadism: Results of a Pharmacokinetic Clinical Study, JUrol.,2008,180,6,2307-2313,United States, PMID 18930255

    6. Ouyang P, Vaidya D, Dobs A, Golden S, Szklo M, Heckbert S, Kopp P, Gapstur S, Sex Hormone Levels and Subclinical Atherosclerosis , Atherosclerosis, 2008 PMID 18849030

    7. Andrade A, Hendrix C, Parsons T, Caballero B, Yuan C, Flexner C, Dobs A, Brown T, BMC Complementary and Alternative Medicine.,2008,8,50,England, PMID 18713456

    8. Vaidya D, Dobs A, Gapstur S, Golden S, Hankinson A, Liu K, Ouyang P, The Association of Endogenous Sex Hormones with Lipoprotein Subfraction Profile in the Multi-Ethnic Study of Atheroschlerosis, Metabolism, 2008,57,6,782-790, United States, PMID 18502260

    9. Pfeil E., Dobs A, Current and Future Testosterone Delivery Systems for Treatment of the Hypogonadal Male, Expert Opin. Drug Deliv., 2008 5,4,471-481, England, PMID 18426387

    10. Cofrancesco J, Scherzer R, Tien P, Gilbert C, Southwell H, Sidney S, Dobs A, Grunfeld C, Illicit Drug Use and HIV Treatment Outcomes in a US Cohort, AIDS,2008,22,3,357-365, England, PMID 18195562

    Journal Citations

    Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. Cancer. 2006 Feb 1;106(3):581-588.

    Braga-Basaria, M.; Dobs, A.S.; Muller, D.C.; Carducci, M.A.; John, M.; Egan, J.; Basaria, S. Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol. 2006 Aug 20;24(24):3979-3983.

    Braga-Basaria, M.; Muller, D.C.; Carducci, M.A.; Dobs, A.S.; Basaria, S. Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy. International journal of impotence research. 2006 Sep-Oct;18(5):494-498.

    Levinson, N.M.; Kuchment, O.; Shen, K.; Young, M.A.; Koldobskiy, M.; Karplus, M.; Cole, P.A.; Kuriyan, J. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol. 2006 May;4(5):e144.

    Maggio, M.; Blackford, A.; Taub, D.; Carducci, M.; Ble, A.; Metter, E.J.; Braga-Basaria, M.; Dobs, A.; Basaria, S. Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. J Androl. 2006 Nov-Dec;27(6):725-728.

    Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancer. Archives of internal medicine. 2007 Mar 26;167(6):612-613.

    Rohrmann, S.; Nelson, W.G.; Rifai, N.; Brown, T.R.; Dobs, A.; Kanarek, N.; Yager, J.D.; Platz, E.A. Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. J Clin Endocrinol Metab. 2007 Jul;92(7):2519-2525.

    Selvin, E.; Feinleib, M.; Zhang, L.; Rohrmann, S.; Rifai, N.; Nelson, W.G.; Dobs, A.; Basaria, S.; Golden, S.H.; Platz, E.A. Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007 Feb;30(2):234-238.

    Paller, C.J.; Shiels, M.S.; Rohrmann, S.; Basaria, S.; Rifai, N.; Nelson, W.; Platz, E.A.; Dobs, A. Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men. Clinical endocrinology. 2009 Jan;70(1):26-34.

    Sharma, P.; Wisniewski, A.; Braga-Basaria, M.; Xu, X.; Yep, M.; Denmeade, S.; Dobs, A.S.; DeWeese, T.; Carducci, M.; Basaria, S. Lack of an effect of high dose isoflavones in men with prostate cancer undergoing androgen deprivation therapy. J Urol. 2009 Nov;182(5):2265-2272.

    Shiels, M.S.; Rohrmann, S.; Menke, A.; Selvin, E.; Crespo, C.J.; Rifai, N.; Dobs, A.; Feinleib, M.; Guallar, E.; Platz, E.A. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes Control. 2009 Aug;20(6):877-886.

    Menke, A.; Guallar, E.; Rohrmann, S.; Nelson, W.G.; Rifai, N.; Kanarek, N.; Feinleib, M.; Michos, E.D.; Dobs, A.; Platz, E.A. Sex steroid hormone concentrations and risk of death in US men. Am J Epidemiol. 2010 Mar 1;171(5):583-592.

    Mondul, A.M.; Selvin, E.; Rohrmann, S.; Menke, A.; Feinleib, M.; Kanarek, N.; Rifai, N.; Dobs, A.S.; Platz, E.A. Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III. Cancer Causes Control. 2010 Oct;21(10):1575-1583.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Memberships

    • The Endocrine Society, 1987
    • American Andrology Society, 1994
    • Institute of Medicine Roundtable in Clinical Research, 2000

    Professional Activities

    • Medical Residency, Albert Einstein College of Medicine, 1978 - 1981
      Internal Medicine
    • Vice-Chair , Johns Hopkins University School of Medicine, 1996 - 2001
      Department of Medicine Clinical Research
    • Director, Clinical Trials Unit of Johns Hopkins School of Medicine, 1998
    • Director, Johns Hopkins Center for Complementary and Alternative Medicine¬†, 2001 - 2007
    • Vice-Chair , Johns Hopkins University School of Medicine, 2001
      Department of Medicine Faculty Development
    • Director , JHU-SYSU (China) Clinical Reserach Collaboration, 2011
    • Director, NCI-funded Center to Reduce Cancer Disparities, 2012
  • Videos & Media +
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