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Henry Halperin, M.D.

Photo of Dr. Henry Halperin, M.D.

Co-director, Johns Hopkins Imaging Institute of Excellence

Professor of Medicine

Male

Expertise: Cardiac Electrophysiology, Cardiac Imaging, Cardiopulmonary Resuscitation, Cardiovascular Diseases, Electrophysiology, Heart Disease

Research Interests: Cardiopulmonary Resuscitation; Computed Tomography; Magnetic Resonance Imaging; Image Guided Electrophysiology Intervention; Sudden Death

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Locations

The Johns Hopkins Hospital
Appointment Phone: 443-997-0270

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-2412

Background

Dr Halperin received the B.S degree in physics with highest distinction from Purdue University, the M.A. degree in physics from the University of California, Berkeley, and the M.D. degree from Louisiana State University, New Orleans, Louisiana. He is a member of Phi Beta Kappa, an Established Investigator and Fellow of the American Heart Association, and a McClure Fellow of the Johns Hopkins University Applied Physics laboratory.

Dr. Halperin is currently a Professor of Medicine, Radiology and Biomedical Engineering at the Johns Hopkins Medical Institutions. He is the co-Director of the Cardiovascular Imaging Center of Excellence. He serves on the editorial board of the journal Resuscitation, and is a past chair of the national American Heart Association Advanced Cardiovascular Life Support Subcommitte and a past member of the Emergency Cardiac Care Committee. Ten of his students have received young investigator awards from the American Heart Association and Heart Rhythm Society, and he has ongoing support from the National Institutes of Heath for his research programs. He has over 120 peer-reviewed publications and over 20 patents issued.
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Titles

  • Co-director, Johns Hopkins Imaging Institute of Excellence
  • Director, Advanced Cardiovascular Life Support
  • Professor of Medicine
  • Professor of Biomedical Engineering
  • Professor of Radiology and Radiological Science

Centers & Institutes

Education

Degrees

  • MD, Louisiana State University School of Medicine (1977)

Residencies

  • Louisiana State University School of Medicine / Internal Medicine (1980)

Fellowships

  • Johns Hopkins University School of Medicine / Cardiology (1984)

Board Certifications

  • American Board of Internal Medicine / Cardiovascular Disease (1983)
  • American Board of Internal Medicine / Clinical Cardiac Electrophysiology (2009)
  • American Board of Internal Medicine / Internal Medicine (1981)

Research & Publications

Selected Publications

1. Dickfeld T, Calkins H, Zviman M, Kato R, Meininger G, Lickfett L, Berger R, Halperin H, Solomon SB: Anatomic stereotactic catheter ablation on three-dimensional magnetic resonance images in real time. Circulation. 2003 Nov 11;108(19):2407-13. Epub 2003 Oct 20.


2. Roguin A, Zviman M, Meininger G, Rodriguez ER, Dickfeld T, Bluemke D, Lardo A, Berger R, Calkins H, Halperin H: Modern pacemaker and implantable cardioverter-defibrillator systems can be MRI safe: In-vitro and in-vivo assessment of safety and function at 1.5-Tesla. Circulation. 2004 Aug 3;110(5):475-82.


3. Nazarian S, S, Bluemke D, Lardo A, Zviman M, Watkins S, Dickfeld T, Meininger G, Roguin A, Calkins H, Tomaselli G, Weiss RG, Berger R, Lima J, Halperin H: Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in non-ischemic cardiomyopathy. Circulation. 2005;112:2821-5.


4. Dickfeld T, Kato R , Zviman M, Meininger G , Lardo A , Roguin A, Bluemke D, Berger R, Calkins H, Halperin H: Characterization of radiofrequency ablation lesions with gadolinium-enhanced cardiovascular magnetic resonance imaging. J Am Coll Cardiol. 2006;47:370-8.


5. Dong J, Calkins H, Solomon SB, Lai S, Dalal D, Lardo A, Brem E, Preiss A, Berger RD, Halperin H, Dickfeld T. Integrated electroanatomic mapping with three-dimensional computed tomographic images for real-time guided ablations. Circulation. 2006;113:186-94.


6. Lardo AC, Cordeiro MA, Silva C, Amado LC, George RT, Saliaris AP, Schuleri KH, Fernandes VR, Zviman M, Nazarian S, Halperin HR, Wu KC, Hare JM, Lima JA. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation. 2006;113:394-404


7. Nazarian S, Roguin A, Zviman M, Lardo A, Dickfeld T, Calkins H , Berger R, Bluemke D, Halperin H: Clinical Utility and Safety of a Protocol for Non-Cardiac and Cardiac Magnetic Resonance Imaging of Patients with Permanent Pacemakers and Implantable Cardioverter Defibrillators at 1.5 Tesla. Circulation. 2006;114(12):1277-84. Epub 2006 (Featured)


8. Dickfeld T, Kato R, Zviman M, Nazarian S, Dong J, Ashikaga H, Lardo AC, Berger RD, Calkins H, Halperin H.Characterization of acute and subacute radiofrequency ablation lesions with nonenhanced magnetic resonance imaging. Heart Rhythm. 2007 Feb;4(2):208-14.


9. Halperin, H; American Heart Association: Recommendations for implementation of community consultation and public disclosure under the Food and Drug Administration "exception from informed consent requirements for emergency research": testimony of the American Heart Association. Acad Emerg Med. 2007 Apr;14(4):e37-9.


10. Halperin H, Paradis N, Mosesso V Jr, Nichol G, Sayre M, Ornato JP, Gerardi M, Nadkarni VM, Berg R, Becker L, Siegler M, Collins M, Cairns CB, Biros MH, Vanden Hoek T, Peberdy MA: Recommendations for implementation of community consultation and public disclosure under the Food and Drug Administration''s "Exception from informed consent requirements for emergency research": A special report from the American Heart Association Emergency Cardiovascular Care Committee and Council on Cardiopulmonary, Perioperative and Critical Care: Endorsed by the American College of Emergency Physicians and the Society for Academic Emergency Medicine. Circulation. 2007 Oct 16;116(16):1855-63. Epub 2007 Sep 24. [Comment in JAMA. 2007;298(22):2608-2609].


11. Berger RD, Palazzolo J, Halperin H. Rhythm discrimination during uninterrupted CPR using motion artifact reduction system. Resuscitation. 2007 Oct;75(1):145-52. Epub 2007 Apr 30.


12. Tandri H, Zviman MM, Wedan SR, Lloyd T, Berger RD, Halperin H. Determinants of gradient field-induced current in a pacemaker lead system in a magnetic resonance imaging environment. Heart Rhythm. 2008 Mar;5(3):462-8. Epub 2007 Dec 27.


13. Nazarian S, Kolandaivelu A, Zviman MM, Meininger G, Kato R, Susil R, Roguin A, Dickfeld T, Ashikaga H, Calkins H, Berger RD, Bluemke D, Lardo A, Halperin HR: Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studies. Circulation. 2008 Jul 15;118(3):223-9.


14. Nazarian S, Kantsevoy SV, Zviman MM, Matsen FA 3rd, Calkins H, Berger RD, Halperin HR: Feasibility of endoscopic guidance for nonsurgical transthoracic atrial and ventricular epicardial ablation. Heart Rhythm. 2008 Aug;5(8):1115-9. Epub 2008 May 9.

Patents

CPR Chest Compression Monitor and Method of Use
Patent # US8968224 B2 | 03/03/2015

A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals directing a chest compression force being applied to the chest and a frequency of such compressions.

Band Stop Filter Employing a Capacitor And an Inductor Tank Circuit to Enhance MRI Compatibility of Active Medical Devices
Patent # US8897887 B2 | 11/25/2014

A band stop filter is provided for a lead wire of an active medical device (AMD). The band stop filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the band stop filter is resonant at a selected frequency. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the band stop filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the band stop filter is integrated into a TIP and/or RING electrode for an active implantable medical device.

ECG Artifact Reduction System
Patent # US8666480 B2 | 03/04/2014

An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR.

Band Stop Filter Employing a Capacitor And an Inductor Tank Circuit to Enhance MRI Compatibility of Active Medical Devices
Patent # US8275466 B2 | 09/25/2012

A band stop filter is provided for a lead wire of an active medical device (AMD). The band stop filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the band stop filter has a Q with the resultant 3 dB bandwidth being in the megahertz range. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the band stop filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the band stop filter is integrated into a TIP and/or RING electrode for an active implantable medical device.

CPR Chest Compression Monitor And Method of Use
Patent # US8147433 B2 | 04/03/2012

A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals directing a chest compression force being applied to the chest and a frequency of such compressions.

Band stop filter employing a capacitor and an inductor tank
Patent # US7363090 B | 04/22/2008

Band stop filter employing a capacitor and an indcutor tank circuit to enhance MRI compatability of active implantable medical devices.

Activities & Honors

Honors

  • Eagle Scout, 1964
  • Phi Beta Kappa, 1970
  • Richard King Award for Outstanding Senior, Purdue University, 1971
  • B.S. With Highest Distinction, Purdue University, 1971
  • National Science Foundation Fellowship, 1971 - 1972
  • Physician Scientist, National Institutes of Health, 1984 - 1989
  • Established Investigator, American Heart Association, 1989 - 1994
  • McClure Fellow, Johns Hopkins Applied Physics Laboratory, 1998 - 2001
  • Fellow, American Heart Association, 2001

Memberships

  • American Heart Association
  • Electrophysiology Society
  • Heart Rhythm Society
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