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Photo of Dr. Jeffrey Rothstein

Jeffrey Rothstein, M.D., Ph.D.

Jeffrey David Rothstein, M.D., Ph.D.
Director, Robert Packard Center for ALS Research
Professor of Neurology


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Robert Packard Center for ALS Research
  • Professor of Neurology
  • Professor of Neuroscience

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-614-5972

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-614-5972

601 N. Caroline Street
Baltimore, MD 21287 map


Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, Neurology, Neuromuscular Disease

Research Interests

Various molecular mechanisms of selective neurodegeneration in motor neuron diseases such as amyotrophic lateral sclerosis; Identification of novel drug or peptide therapeutics to delay or prevent motor neuron degeneration in ALS through the use of cell culture and transgenic models of ALS; Use of neuronal and non-neuronal stem cell therapies to treat motor neurons diseases including ALS and Spinal Muscular Atrophy; Models of motor axon regeneration regrowth; Basic biology of glutamate transporters and their role in acute and chronic neuronal degeneration (e.g. ALS, epilepsy, stroke, spinocerebellar ataxia); Cloning and characterization of novel proteins which may be responsible for the cellular regulation of glutamate transporters.


Dr. Jeffrey Rothstein focuses on neuromuscular diseases, with a particular focus on Amyotrophic lateral sclerosis (ALS). Other clinical areas relevant to his laboratory-based research include: idiopathic stupor, epilepsy and motor neuron degeneration.

His laboratory includes more than 20-post doctoral fellows, neurology residents, neuromuscular and epilepsy fellows, undergraduate students, technicians and ALS clinic staff. He has been the principal and/or local investigator in eight national or international trials in ALS. He is the author of more than 100 articles on basic and clinical neuroscience. Dr. Rothsteins laboratory research is funded through the National Institutes of Health, the Muscular Dystrophy Association, the ALS Association and Project A.L.S.

Dr. Jeffrey Rothstein received a masters degree in neurochemistry from the University of Chicago and a Ph.D. in physiology and biophysics from the University of Illinois Health Sciences Center. He then obtained his medical degree from the University of Illinois College of Medicine. He went on to complete an internship at the University of North Carolina Memorial Hospital before joining The Johns Hopkins for his residency. While at Johns Hopkins, he became chief resident in neurology and completed his fellowship in neuromuscular disease. more

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