Skip Navigation
Find a Doctor


Photo of Dr. David Pearse

David Pearse, M.D.

David B. Pearse, M.D.
Medical Director, Johns Hopkins Bayview Hospital MICU
Professor of Medicine


Appointment Phone


Main Location

Johns Hopkins Bayview Medical Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Medical Director, Johns Hopkins Bayview Hospital MICU
  • Professor of Medicine



Johns Hopkins Outpatient Center

Appointment Phone: 410-955-3467

601 N. Caroline Street
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864

5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map

The Johns Hopkins Hospital

Appointment Phone: 410-550-5864

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-3467


Critical Care Medicine , Pulmonary Disease and Critical Care Medicine, Pulmonary Medicine

Research Interests

Pulmonary endothelial barrier function; Acute lung injury; Pulmonary thromboembolism

    Additional Information

  • Education +
    • B.S., University of Florida (Florida) (1977)
    • M.D., University of Florida (Florida) (1980)
  • Research & Publications +

    Selected Publications View all on PubMed

    1. Stephens RS, Servinsky LE, Rentsendorj O, Kolb TM, Pfeifer A, and Pearse DB. Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase. Am J Physiol Cell Physiol. 2014; 306(6); C559-C569. PMID: 24401847 [PubMed - in process]

    2. Kolb TM, King LS, Pearse DB. A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces. Chest. 2013 Dec 1;144(6):1964-8. doi: 10.1378/chest.13-0902. PMID: 24297131 [PubMed - in process]

    3. Anidi IU, Servinsky LE, Rentsendorj O, Stephens RS, Scott AL, Pearse DB. CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei. PLoS One. 2013 Aug 15;8(8):e71010. doi: 10.1371/journal.pone.0071010. eCollection 2013. PMID: 23967147 [PubMed - in process]

    4. D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 1;189(5):2234-45. doi: 10.4049/jimmunol.1102606. Epub 2012 Jul 27. PMID: 22844117

    5. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug;18(8):1217-23. doi: 10.1038/nm.2843. Epub 2012 Jul 22. PMID: 22820644

    6. Eberlein M, Reed RM, Permutt S, Chahla MF, Bolukbas S, Nathan SD, Iacono A, Pearse DB, Fessler HE, Shah AS, Orens JB, Brower RG. Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation. J Heart Lung Transplant. 2012 Nov;31(11):1207-1213.e7. doi: 10.1016/j.healun.2011.07.015. Epub 2011 Oct 28. PMID: 22036314

    7. Eberlein M, Permutt S, Chahla MF, Bolukbas S, Nathan SD, Shlobin OA, Shelhamer JH, Reed RM, Pearse DB, Orens JB, Brower RG. Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome. Chest. 2012 Feb;141(2):451-60. doi: 10.1378/chest.11-0767. Epub 2011 Jul 28. PMID: 21799025

    8. Rentsendorj O, Damarla M, Aggarwal NR, Choi JY, Johnston L, D'Alessio FR, Crow MT, Pearse DB. Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L161-70. doi: 10.1152/ajplung.00073.2011. Epub 2011 May 13. PMID: 21571906

    9. Eberlein M, Permutt S, Brown RH, Brooker A, Chahla MF, Bolukbas S, Nathan SD, Pearse DB, Orens JB, Brower RG. Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival. Am J Respir Crit Care Med. 2011 Jan 1;183(1):79-87. doi: 10.1164/rccm.201004-0593OC. Epub 2010 Aug 6. PMID: 20693376

  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
Is This You? Edit Profile

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.