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Juan C Troncoso, MD

Director, Clinical and Neuropathology Core
Professor of Pathology
Appointment Phone


Main Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Clinical and Neuropathology Core
  • Director, Brain Resource Center
  • Professor of Pathology
  • Associate Professor of Neurology

Centers & Institutes

  • Alzheimer's Disease Research Center
  • Morris K. Udall Parkinson's Disease Research Center



Research Interests

Neurodegenerative diseases, including Alzheimer''s disease; Forensic neuropathology; Trauma of the brain and spinal cord


Dr. Juan Troncoso is a professor of pathology and associate professor of neurology at the Johns Hopkins University School of Medicine. He is a board-certified neurologist/neuropathologist with expertise in the pathological diagnosis of dementias and the neuropathology of normal aging.

Dr. Troncoso serves as the director of the Brain Resource Center, which he established, and director of the Clinical and Neuropathology Core at the Johns Hopkins Udall Center.

He earned his M.D. from Pontificia Universidad Católica de Chile. He completed a residency in pathology at The Johns Hopkins Hospital and a residency in neurology at Hahnemann Medical College in Philadelphia. He performed a fellowship in pathology at the Johns Hopkins School of Medicine.

Dr. Troncoso's research interests include neurodegenerative diseases, such as Alzheimer''s disease; forensic neuropathology; and trauma of the brain and spinal cord.

He has authored more than 70 publications, and has served as neuropathologist for the Office of the Chief Medical Examiner of Maryland since 1981. He is a faculty member of the Aging and Dementia Training Program at Johns Hopkins.


  • English
  • Spanish
Additional Resources +
  • Education +


    • Faculty of Medicine Pontifica Univesity Catolica De chile (Santiago) (1973)


    • Johns Hopkins University School of Medicine / Pathology (Baltimore MD ) (1979)
    • Hahnemann University Hospital / Neurology (Philadelphia PA ) (1978)


    • Johns Hopkins University School of Medicine / Pathology (Baltimore MD ) (1983)


    • American Board of Pathology / Neuropathology (1983)
    • American Board of Psychiatry & Neurology / Neurology (1980)
  • Research & Publications +

    Research Summary

    Dr. Troncoso’s research focuses on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders.

    His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically engineered mouse models and in vitro systems.

    Selected Publications

    1. Iacono D, Resnick SM, O'Brien R, Zonderman AB, An Y, Pletnikova O, Rudow G, Crain B, Troncoso JC. “Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes.” J Neuropathol Exp Neurol. 2014 Apr;73(4):295-304. doi: 10.1097/NEN.0000000000000052.
    2. Riudavets MA, Bartoloni L, Troncoso JC, Pletnikova O, St George-Hyslop P, Schultz M, Sevlever G, Allegri RF. “Familial dementia with frontotemporal features associated with M146V presenilin-1 mutation.” Brain Pathol. 2013 Sep;23(5):595-600. doi: 10.1111/bpa.12051. Epub 2013 Apr 25.
    3. Driscoll I, Troncoso JC, Rudow G, Sojkova J, Pletnikova O, Zhou Y, Kraut MA, Ferrucci L, Mathis CA, Klunk WE, O'Brien RJ, Davatzikos C, Wong DF, Resnick SM. “Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques.” Acta Neuropathol. 2012 Dec;124(6):823-31. doi: 10.1007/s00401-012-1025-1. Epub 2012 Aug 5.
    4. Airavaara M, Pletnikova O, Doyle ME, Zhang YE, Troncoso JC, Liu QR. “Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease.” J Biol Chem. 2011 Dec 30;286(52):45093-102. doi: 10.1074/jbc.M111.310250. Epub 2011 Nov 11.


    Dr. Troncoso’s laboratory has conducted apoE genotyping for more than a decade, serving the Division of Neuropathology and other investigators in the JHMI research community.

    CORE Facilities

    Clinical and Neuropathology Core, Udall Center

  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Neuropathology-Neurology (Course Director)

  • Activities & Honors +

    Professional Activities

    Member, National Institute on Aging Study Section, National Institutes of Health

  • Videos & Media +
  • Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-2660
    Location Map


    • Pathology

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