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Photo of Dr. Howard Mark Lederman, M.D., Ph.D.

Howard Mark Lederman, M.D., Ph.D.

Director, Immunodeficiency Clinic
Professor of Pediatrics


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Immunodeficiency Clinic
  • Director, Ataxia-Telangiectasia Clinical Center
  • Director, Pediatric Immunology Laboratory
  • Professor of Pediatrics
  • Joint Appointment in Medicine

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-955-5883

600 N. Wolfe Street
Sheikh Zayed Tower Suite 1102
Baltimore, MD 21287 map
Phone: 410-955-5883
Fax: 410-955-0229


Allergy and Immunology, Antibody Deficiency, Ataxia-Telangiectasia, Chronic Granulomatous Disease, Common Variable Immunodeficiency, Complement Deficiency, DiGeorge Syndrome, Gamma Globulin Therapy, Hyper-IgE Syndrome, Hyper-IgM Syndrome, Hypogammaglobulinemia, IgA Deficiency, IgM Deficiency, Leukocyte Adhesion Deficiency, Primary Immunodeficiency Diseases, Severe Combined Immunodeficiency, Wiskott-Aldrich Syndrome, X-linked Agammaglobulinemia

Research Interests

Primary Immunodeficiency Diseases; Ataxia-Telangiectasia; IgA deficiency; Common variable immunodeficiency; Chronic granulomatous disease and other disorders of phagocytes; Severe combined immunodeficiency; Hypogammaglobulinemia; Immunoglobulin therapy; IVIG; DiGeorge syndrome; Wiskott-Aldrich syndrome; Hyper-IgM syndrome; Hyper-IgE syndrome; Complement deficiency; X-linked agammaglobulinemia; Antibody deficiency; IgM deficiency


Dr. Howard Lederman is a professor of pediatrics at the Johns Hopkins University School of Medicine. He is the director of the Immunodeficiency Clinic, the Pediatric Immunology Laboratory, and the Ataxia-Telangiectasia (A-T) Clinical Center.  

Dr. Lederman specializes in the evaluation, diagnostic testing and long-term management of patients of all ages who have known or suspected primary immunodeficiency diseases. He is an expert on the use of gamma globulin therapy for a wide variety of disorders. 

After receiving his M.D. and Ph.D. from the University of Michigan, Dr. Lederman came to Johns Hopkins Children’s Center for a residency in pediatrics, followed by a fellowship in immunology at the Hospital for Sick Children in Toronto. 

Dr. Lederman’s current research laboratory and clinical research focuses on better understanding and treating patients with ataxia-telangiectasia, a devastating neurological disorder for which there is no cure.

He is a member of numerous professional societies, including American Association of Immunologists, the American Society for Microbiology and the Clinical Immunology Society. more

    Additional Information

  • Education +


    • University of Michigan Medical School / MD (1977)


    • Johns Hopkins University School of Medicine / Pediatrics (1981)


    • Hospital for Sick Children / Immunology (1983)


    • American Board of Pediatrics / Pediatrics (1984)
  • Research & Publications +

    Research Summary

    Dr. Lederman’s current research laboratory and clinical research focuses on better understanding and treating patients with ataxia-telangiectasia, a devastating neurological disorder for which there is no cure.

    Clinical Trials:

    Cell-Based Approaches For Modeling and Treating Ataxia-Telangiectasia

    Clinical Trial Keywords: Immunoglobulin, Gamma globulin, Ataxia- Telangiectasia

    Selected Publications

    McGrath-Morrow S, Lefton-Greif M, Rosquist K, Crawford T, Kelly A, Zeitlin P, Carson K , Lederman HM. "Pulmonary function in adolescents with ataxia-telangiectasia." Pediatr Pulmonol. 2008 Jan;43(1):59-66.

    Daniels JA, Maitra A, Lederman HM, and Montgomery E. "Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): A clinicopathologic study and review." Am J Surg Pathol. 2007 Dec;31(12):1800-12.

    Alterman N, Fattal-Valevski A, Moyal L, Crawford TO, Lederman HM, Ziv Y, and Shiloh Y. "Ataxia-Telangiectasia: Mild neurological presentation despite null ATM mutation and severe cellular phenotype." Am J Med Genet A. 2007 Aug 15;143A(16):1827-34.

    Shreffler WG, Visness CM, Burger M, Cruikshank WW, Lederman HM, de la Morena M, Grindle K, Calatroni A, Sampson HA and Gern JE. "Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study." BMC Immunol. 2006 Dec 12;7:29.

    Lin, DDM, Crawford TO, Lederman HM, Barker PB. "Proton MR Spectroscopic Imaging in Ataxia-Telangiectasia." Neuropediatrics. 2006 Aug;37(4):241-6.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • American Association of Immunologists 
    • American Society for Microbiology 
    • Clinical Immunology Society 
    • Infectious Diseases Society of America
    • Society for Pediatric Research 
  • Videos & Media +
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