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Scott Lee Kominsky, Ph.D.

Photo of Dr. Scott Lee Kominsky, Ph.D.

Director of Research Education

Associate Professor of Orthopaedic Surgery

Research Interests: Novel prophylactic and therapeutic modalities for bone metastasis; Mechanisms of metastatic tumor cell homing to and growth in bone; Molecular genetics of breast cancer ...read more

Background

Dr. Scott Kominsky is an associate professor of orthopaedic surgery and oncology at the Johns Hopkins University School of Medicine. His research focuses on molecular genetics of breast cancer, mechanisms of metastatic tumor cell homing to and growth in bone, and novel prophylactic therapeutic modalities for bone metastasis. Dr. Kominsky serves as the director of Research Education within the department of Orthopaedic Surgery and is the assistant director of the Basic Science Laboratory.

Dr. Kominsky and the Basic Science Laboratory team are engaged in conducting studies to better understand the molecular genetics of breast cancer and the mechanisms of metastatic tumor cell homing to and growth in the bone. The research goals are to identify key interactions between metastatic tumor cells and the bone environment with the aim of developing novel prophylactic and therapeutic modalities for bone metastasis and identify genetic differences between normal and cancerous breast tissues that can be used for diagnostic, prognostic, and therapeutic applications.

Dr. Kominsky earned his Ph.D. from the University of Florida and completed a fellowship at Johns Hopkins University School of Medicine. He was named a Johns Hopkins Musculoskeletal Research Grant Awardee for Orthopaedic Surgery: “Role of the CCL20/CCR6 Axis in Bone.”

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Titles

  • Director of Research Education
  • Assistant Director, Basic Science Laboratory
  • Associate Professor of Orthopaedic Surgery
  • Associate Professor of Oncology

Departments / Divisions

Education

Degrees

  • B.S., University of Florida (Florida) (1995)
  • Ph.D., University of Florida (Florida) (2000)

Research & Publications

Research Summary

The primary goal of Dr. Kominsky’s research is to elucidate the molecular mechanisms responsible for breast and kidney cancer homing to and growth in the bone environment in order to develop novel preventative and therapeutic modalities for bone metastasis. The secondary goal of his research is to develop and test experimental therapeutics for primary musculoskeletal tumors including osteosarcoma and chondrosarcoma.

Lab

The Basic Science Laboratory is conducting studies to better understand the molecular genetics of breast cancer and the mechanisms of metastatic tumor cell homing to and growth in the bone. The goals of our research are to identify key interactions between metastatic tumor cells and the bone environment with the aim of developing novel prophylactic and therapeutic modalities for bone metastasis and to identify genetic differences between normal and cancerous breast tissues that can by used for diagnostic, prognostic and therapeutic applications.

Selected Publications

View all on Pubmed

  1. Lau WM, Doucet M, Stadel R, Huang D, Weber KL, Kominsky SL. "Enpp1: a potential facilitator of breast cancer bone metastasis." PLoS One. 2013 Jul 5;8(7):e66752. doi: 10.1371/journal.pone.0066752. Print 2013.
  2. Lau WM, Doucet M, Huang D, Weber KL, Kominsky SL. "CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells." Biochem Biophys Res Commun. 2013 Jul 26;437(2):261-6. doi: 10.1016/j.bbrc.2013.06.063. Epub 2013 Jun 27.
  3. Weber KL, Doucet M, Shaner A, Hsu N, Huang D, Fogel J, Kominsky SL. "MIP-1δ activates NFATc1 and enhances osteoclastogenesis: involvement of both PLCγ2 and NFκB signaling." PLoS One. 2012;7(7):e40799. doi: 10.1371/journal.pone.0040799. Epub 2012 Jul 9.
  4. Stearns V, Mori T, Jacobs LK, Khouri NF, Gabrielson E, Yoshida T, Kominsky SL, Huso DL, Jeter S, Powers P, Tarpinian K, Brown RJ, Lange JR, Rudek MA, Zhang Z, Tsangaris TN, Sukumar S. "Preclinical and clinical evaluation of intraductally administered agents in early breast cancer." Sci Transl Med. 2011 Oct 26;3(106):106ra108. doi: 10.1126/scitranslmed.3002368.
  5. Lau WM, Weber KL, Doucet M, Chou YT, Brady K, Kowalski J, Tsai HL, Yang J, Kominsky SL. "Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2." Int J Cancer. 2010 Feb 15;126(4):876-84. doi: 10.1002/ijc.24780.

Activities & Honors

Honors

  • Grant Awardee for Orthopaedic Surgery: "Role of the CCL20/CCR6 Axis in Bone", Johns Hopkins Musculoskeletal Research, 2012 - 2013
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