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Douglas J. Digirolamo, Ph.D.

Photo of Dr. Douglas J. Digirolamo, Ph.D.

Assistant Professor of Orthopaedic Surgery

Research Interests: Musculoskeletal biology

Background

Douglas J. Digirolamo, Ph.D., is an assistant professor of orthopaedic surgery at the Johns Hopkins School of Medicine.

A researcher, Dr. Digirolamo specializes in musculoskeletal biology—in particular, studying the pathways that enable the communication between bone and skeletal muscle that is necessary for them to coordinate their development and mass. He joined the Johns Hopkins faculty in 2009.

Dr. Digirolamo’s prior research interests have included the roles of GH and IGF-1 signaling in skeletal development, breast-cancer bone metastasis, and cancer angiogenesis.

He is affiliated with the American Society for Bone & Mineral Research and The Endocrine Society, and has also served as the administrative editor of the Journal of Bone and Mineral Research.

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Titles

  • Assistant Professor of Orthopaedic Surgery

Departments / Divisions

Education

Degrees

  • B.S., Pennsylvania State University (Pennsylvania) (2001)
  • Ph.D., University of Alabama (Alabama) (2008)

Research & Publications

Research Summary

Dr. Digirolamo’s research focuses on musculoskeletal biology—in particular, the pathways that enable the communication between bone and skeletal muscle that is necessary for them to coordinate their development and mass.

Selected Publications

View all on Pubmed

  1. Yilgor Huri P, Cook CA, Hutton DL, Goh BC, Gimble JM, DiGirolamo DJ, Grayson WL. "Biophysical cues enhance myogenesis of human adipose derived stem/stromal cells." Biochem Biophys Res Commun. 2013 Aug 16;438(1):180-5. doi: 10.1016/j.bbrc.2013.07.049. Epub 2013 Jul 20.
  2. DiGirolamo DJ, Kiel DP, Esser KA. "Bone and skeletal muscle: neighbors with close ties." J Bone Miner Res. 2013 Jul;28(7):1509-18. doi: 10.1002/jbmr.1969. Review.
  3. DiGirolamo DJ, Clemens TL, Kousteni S. "The skeleton as an endocrine organ." Nat Rev Rheumatol. 2012 Nov;8(11):674-83. doi: 10.1038/nrrheum.2012.157. Epub 2012 Oct 9. Review.
  4. Mavalli MD, DiGirolamo DJ, Fan Y, Riddle RC, Campbell KS, van Groen T, Frank SJ, Sperling MA, Esser KA, Bamman MM, Clemens TL. "Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice." J Clin Invest. 2010 Nov;120(11):4007-20. doi: 10.1172/JCI42447.
  5. Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL. "Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition." Cell. 2010 Jul 23;142(2):309-19. doi: 10.1016/j.cell.2010.06.002.

Activities & Honors

Honors

  • President's Poster Competition Award, American Society for Bone and Mineral Research (ASBMR), 2010
  • Harold Frost Young Investigator Award, ASBMR/International Bone and Mineral Society, 2010
  • Most Outstanding Pathology Graduate Student, University of Alabama at Birmingham, 2005
  • ASBMR Young Investigator Award, American Society for Bone and Mineral Research, 2005
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