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April 2, 2001
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Johns Hopkins Experts Launch Handheld Digital Guide To Antibiotics and Infectious Disease for Practicing Physicians

- -Service is free and available on World Wide Web and for Microsoft PocketPC-based handheld computers

Johns Hopkins today launched a rigorously peer-reviewed database and a point of care decision- support system designed to give office and hospital-based physicians free and up-to-the-minute information on antibiotics and their proper use.

Capitalizing on the popularity of handheld personal digital assistants (PDAs) pocket computers, and developed in part to address a growing national concern over antibiotic drug resistance and the inappropriate prescription of drugs, the Antibiotics Guide (ABX Guide) is the first in a planned series of easily navigated, regularly updated digital medical specialty handbooks from Hopkins experts. The Guide works on both the Web (http://hopkins-abxguide.org) and so-called personal digital assistants, or PDAs, such as the. Microsoft created the PocketPC.

Instead of carrying quickly outdated and limited paper versions of drug references, users of the ABX Guide carry critically edited electronic versions that boil down essential information on drug options and diagnostic criteria. Experts hand-picked by Hopkins continually make updates to reflect changes in the field.. Updates are made regularly by experts whose comments are attributed, along with supporting citations in the literature. Emergency alerts, such as FDA recalls, can be "pushed" to all users in an instant, assuming physicians access the updated database regularly, and preferably daily.

The guide offers information on more than 160 drugs and more than 140 diseases treated by both specialists and primary care physicians.

"We believe this Guide and the technology on which it is based will rapidly advance information evidence-based and outcomes-based medical care, and enrich medical education while addressing key concerns such as medication errors, delays in the incorporation of new developments into practice and antibiotic resistance," says John G. Bartlett, M.D., chief of the Division of Infectious Diseases at Johns Hopkins, who championed the project for Hopkins. These and other concerns were raised in a recent, much publicized national report on the problems of antibiotic use in the United States issued by the Institute of Medicine.

The ABX Guide gives doctors who practice even in remote areas access to the same current diagnostic and treatment guidelines being followed at major medical institutions. The system will also help doctors cope with the estimated 1,500 treatment guidelines that government agencies and medical organizations have developed over the years in an effort to standardize best practices, according to Bartlett.

Unlike other existing digital guides involving infectious diseases, the ABX Guide is heavily annotated and carefully reviewed by specialists at Hopkins and other institutions. "Our strength is that we are teachers and researchers as well as clinicians and ever aware of the need for information to be absolutely accurate and based on the best scientific evidence, not anecdote or convenience," says Walter Atha, M.D., the director of the ABX Guide project. "These academic experts provide candid opinions about inappropriate medication use." In the case of acute bronchitis, for example, for which many clinicians unadvisedly prescribe powerful antibiotics, Bartlett warns, "Donít even think about it!"

According to Atha, extending this application onto secure handheld devices, such as PocketPC, allows the physician to get large amounts of data in his or her hand. "The inclusion of the browser in the PocketPC provides the same look and feel as the browser on the desktop computer, which adds familiarity to the user."

Infectious disease experts who write the ABX Guide can update their assigned sections anytime, from anywhere they have access to the Internet, notes Sharon McAvinue, director of the parent Hopkins initiative known as POC-IT (Point of Care, Information Technology). McAvinue conceived of and spearheaded the ABX Guide project. See sidebar . Johns Hopkins University holds the copyright to all POC-IT content, including the ABX Guide. Under contract to the Infectious Diseases division, Applied Theory (NASDAQ: ATHY), a New York-based company, constructed and will maintain the database and PDA applications. The ABX Guide and future POC-IT applications will soon be available for other PDA operating systems and on other devices such as smart phones.

"Almost all doctors prescribe antibiotics at one time or another," says Atha, an emergency medicine physician at Hopkins. "The ABX Guide isnít just for infectious disease specialists. It will serve the needs of doctors across all specialties." He adds, "the ABX Guide is not designed to take the place of the physicianís own experience or judgment. The goal is to help physicians plan treatments by making the most current information available right at the point of care in the doctorís office or hospital."

"One of the biggest challenges doctors face is trying to keep up with the thought leaders on antibiotic use, " Atha also notes. "New research may find that some drugs arenít effective anymore against certain bacteria, for example, or that certain combinations of drugs shouldnít be used. Thatís why antibiotic guides are one of the most important types of reference a doctor uses."

But thereís too much new information being published in weekly and monthly journals for doctors to keep up with by referring to a guide thatís updated only once a year, Atha says. "Our experts review all current relevant literature on the diagnosis and treatment of infectious diseases and compress that information into recommendations in the form of bullet points."

An important design feature of the ABX Guide, and other planned POC-IT applications, is the ability to gather information anonymously from users, who are required to complete a brief questionnaire on the ABX Guide Web site in order to gain access to the database. POC-IT will then regularly prompt users to update their digest of medical information by downloading newer versions directly into their PDA through a "cradle" attached to their desktop computer.

Currently, as a physician downloads new information from the Web site, POC-IT will collect data about the viewing patterns of registered users. This information will be collected and uploaded from the PDA each time the doctor links to the site through the cradle. Researchers at Hopkins will match those data with answers to the user questionnaire, which consists of five brief demographic questions. The goal is to identify trends in medical practices. Findings will serve as the basis for academic publications and research opportunities.

"This will let us compile an extremely valuable database of prescribing behavior and antibiotic usage trends that reflects how specific diseases are being treated in different settings throughout the country, and could alert practitioners to potential public health problems," says McAvinue. "And because the information is collected anonymously, the names of individual physicians cannot be linked back to them unless they voluntarily submit their e-mail addresses. We believe that there is a wealth of unrecognized clinical expertise in the community that will formally contribute to the advancement of medical knowledge."

A Hopkins oversight board is being formed to consider the potential uses of aggregate data, both academically and commercially, according to McAvinue.

Development of the ABX Guide was funded through unrestricted educational grants to Hopkins POC-IT from Abbott Laboratories, Bristol-Myers Squibb Co., Merck & Co, Ortho McNeill Pharmaceutical, Pfizer Inc., Pharmacia, and Roche Laboratories. Sponsors are acknowledged in a special section on the Web site, but no banner or commercial advertising exists in any of the applications.

The next Hopkins POC-IT Guide, currently in development, will cover treatment of HIV/AIDS.

The Johns Hopkins Antibiotics Guide- -Questions and Answers:  http://www.hopkinsmedicine.org/press/2001/APRIL/010402B.htm

Brief bios of Atha and McAvinue are available at: http://www.hopkinsmedicine.org/press/2001/APRIL/010402A.htm

Microsoft is either registered trademarks of Microsoft Corp. in the United States and/or other countries.

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