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L. Mario Amzel, Ph.D., Professor
3-D structure of proteins: immunoglobulins and other binding proteins; ATP synthase; monoxygenases and dioxygenases quinone reductase.

Namandje N. Bumpus, Ph.D., Assistant Professor
Drug Metabolism and preclinical drug development; small molecule mass spectrometry; targeted metabolomics; antiviral drug-induced toxicity; modulation of cellular signaling pathways by reactive metabolites.

Philip Cole M.D., Ph.D., Professor and Director
Chemical and biochemical approaches in the study of signal transduction, circadian rhythm, and gene regulation.

Robert J. Cotter, Ph.D., Professor
Development of new analytical techniques and instrumentation for mass spectrometry; applications of mass spectrometry to the structural analysis of peptides, glycopeptides, and glycolipids.

Samuel R. Denmeade, M.D., Associate Professor
Targeted therapies for cancer; prodrugs; proteases; peptide libraries.

Phillip A. Dennis, M.D., Ph.D., Professor
Activation of the PI3K/Akt pathway and the biology of lung cancer.

Wade Gibson, Ph.D., Professor
Herpesvirus proteins: studies of their expression, structure, and function using genetic, biochemical, and immunological approaches.

Carol Greider, Ph.D., Professor
Telomerase and telomere length regulation.

S. Diane Hayward, Ph.D., Professor
Epstein-Barr virus; viral latency and B-cell immortalization; DNA-binding proteins in regulation of viral gene expression; mechanisms of virus-induced cell proliferation; notch signaling pathway.

John T. Isaacs, Ph.D., Professor
Anti-cancer drug development; Normal and malignant stem cell biology.

William B. Isaacs, Ph.D., Professor
Understanding the molecular genetic events responsible for initiation and progression of prostate cancer, with particular interest in inherited susceptibility to prostate cancer.

Elizabeth M. Jaffee, M.D., Professor
Analysis of antitumor immune responses against human tumors; identification of the targets of tumor-specific cytotoxic T cells.

Kenneth W. Kinzler, Ph.D., Professor
Molecular genetics of cancer, particularly colorectal cancer and familial adenomatous polyposis.

Daniel J. Leahy, Ph.D., Professor
Molecular studies of signal transduction.

Mark Levis, MD., Ph.D., Associate Professor
Targeting the FLT3 signaling pathway as a treatment for acute leukemia.

Jun Liu, Ph.D., Professor
Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation.

Caren L. Freel Meyers, Ph.D., Assistant Professor
Organic and medicinal chemistry, chemical biology: drug delivery; study of non-mammalian isoprenoid biosynthesis; development of potential therapeutic agents for cancer and infectious disease. 

William G. Nelson, M.D., Ph.D., Professor
Molecular mechanisms of prostatic carcinogenesis; epigenetic alterations in cancer; new approaches to prostate cancer prevention and treatment.

Kenneth J. Pienta, M.D., Professor
The ecology of cancer, tumor microenvironment, metastasis, biomarker development, novel therapeutic development. 

Martin G. Pomper, M.D., Ph.D., Associate Professor
In Vivo molecular and cellular imaging; radiopharmaceutical development; targeted cancer imaging and therapy; functional brain imaging.

Jonathan D. Powell, M.D., Ph.D., Assistant Professor
Mechanisms of T cell activation and tolerance.

Stuart C. Ray, Ph.D., Professor
Computational immunovirology of chronic viral hepatitis.

Douglas N. Robinson, Ph.D., Assistant Professor
Understanding cytokinesis and cell shape control.

Charles M. Rudin, M.D., Ph.D., Associate Professor
Molecular mechanisms of apoptosis; roles of apoptosis in carcinogenesis and therapeutic resistance; novel therapeutic development in animal models of cancer.

Ronald L. Schnaar, Ph.D., Professor
Cell interactions in the nervous system.

James Stivers, Ph.D., Associate Professor
Molecular mechanism and inhibition of enzymes involved in DNA and RNA metabolism.

Saraswati Sukumar, Ph.D., Professor
Molecular alterations in breast cancer.

Paul Talalay, M.D., Professor
Molecular mechanisms involved in chemoprotection against mutagens and carcinogens; catalytic mechanism of the enzymatic transformations of steroid hormones.

Sean D. Taverna, Ph.D., Assistant Professor
Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.

Craig A. Townsend, Ph.D., Professor
Organic and bioorganic chemistry: biosynthesis of natural products and biomimetic synthesis; protein isolation and mechanistic enzymology; molecular biology of secondary metabolism and the applications of biosynthetic systems; study of the role and inhibition of fatty acid synthesis in human cancer and tuberculosis.

Bert Vogelstein, M.D., Professor
Molecular genetics of human cancer.

Srinivasan Yegnasubramanian, M.D., Ph.D., Assistant Professor
Understanding and exploiting alterations in the cancer genome and epigenome for development of biomarkers and therapeutics.

Bert Vogelstein, M.D., Professor
Molecular genetics of human cancer.

Srinivasan Yegnasubramanian, M.D., Ph.D., Assistant Professor
Understanding and exploiting alterations in the cancer genome and epigenome for development of biomarkers and therapeutics.

Jin Zhang, Ph.D., Associate Professor
Cell signaling; kinases and phosphatases; chemotaxis; live-cell imaging; fluorescent proteins and reporters; chemical Biology.

Heng Zhu, Ph.D., Assistant Professor
Signal Transduction, protein network, host-pathogen interaction, protein chip approach to study proteomics.