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S. Diane Hayward

S. Diane Hayward

Department Affiliation: Primary: Oncology; Secondary: Pharmacology and Molecular Sciences, Neurology
Degree: Ph.D., University of Otago, New Zealand
Rank: Professor
Telephone Number: 410-955-2548
Fax Number: 410-502-6802
E-mail address: dhayward@jhmi.edu 
School of Medicine Address: Bunting-Blaustein Cancer Research Building, CRBI 308;1650 Orleans Street, Baltimore, MD 21287
 


Herpesvirus-Host Cell Interactions.

Epstein-Barr virus (EBV) and Kaposi’s sarcoma associated herpesvirus (KSHV) are human herpesviruses that are associated with a variety of malignancies.  We seek to understand the genesis of virus-associated cancers by examining the mechanisms by which virus proteins interact with cell signaling pathways to promote cell proliferation and cell survival.  The laboratory also studies the lytic stage of the EBV and KSHV life cycle that promotes virus persistence and spread.  We have developed virus proteomic arrays as new tools for probing post-translational modifications such as phosphorylation and sumoylation that affect virus protein functions.  The conserved herpesvirus protein kinase is an antiviral drug target.  We are also using mass spectrometry to investigate the changes in the cell environment induced by this kinase to promote virus replication.

Representative Publications:

  • Zhu, J., Liao, G., Shan, L., Zhang, J., Chen, M.R., Hayward, G.S., Hayward, S.D., Desai, P., and Zhu, H.  Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4. J. Virol. 83:5219-5231, 2009. Pub Med Reference
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  • Shamay, M., Greenway, M., Liao, G., Ambinder, R.F., and Hayward, S.D.  De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins.  J. Biol. Chem. 285:36377-86, 2010.  Pub Med Reference
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  • Zheng, D., Wan, J., Cho, Y.G., Wang, L., Chiou, C.-J., Pai, S., Woodard, C., Zhu, J., Liao, G., Martinez-Maza, O., Qian, J., Zhu, H., Hayward, G.S., Ambinder, R.F., and Hayward, S.D.  Comparison of humoral immune responses to Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus using a viral proteome microarray.  J. Infect. Dis.  In press, 2011.
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  • Li, R., Zhu, J., Xie, Z., Liao, G., Liu, J., Chen, M.-R., Hu, S., Woodard, C., Lin, J., Taverna, S., Desai, P., Ambinder, R.F., Hayward, G.S., Qian, J., Zhu, H., and Hayward, S.D.  Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.  Cell Host Microbe 10(4): 390-400, 2011.  Pub Med Reference
     
  • Shamay, M., Liu, J., Li, R., Liao, G., Shen, L., Greenway, M., Hu, S., Zhu, J., Zhi, X., Ambinder, R.F., Qian, J., Zhu, H., Hayward, S.D. A protein array screen for KSHV LANA interactors links LANA to TIP60, PP2A activity and telomere shortening.  J. Virol. 86(9): 5179-91, 2012.  Pub Med Reference
     
  • Li, R., Wang, L., Liao, G., Guzzo, C.M., Matunis, M.J., Zhu, H., Hayward, S.D.  SUMO binding by the Epstein-Barr virus protein kinase GBLF4 is crucial for BGLF4 function.  J. Virol. 86(10): 5412-21, 2012.  Pub Med Reference
     
  • Woodard, C., Shamay, M., Liao, G., Zhu, J., Ng., A.N., Li, R., Newman, R., Rho, H.S., Hu, J., Wan, J., Qian, J., Zhu, H., Hayward, S.D.  Phosphorylation of the chromatin binding domain of KSHV LANA.  PLoS Pathog. 8(10): e1002972, 2012.  Pub Med Reference
     
  • Li, R. and Hayward, S.D.  Potential of protein kinase inhibitors for treating herpesvirus-associated disease.  Trends Microbiol. 21(6): 286-95, 2013.  Pub Med Reference
     

Other graduate programs in which Dr. Hayward participates:

Biochemistry, Cellular and Molecular Biology
Cellular and Molecular Medicine

 
 
 
 
 
 

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