L. Mario Amzel, Ph.D., Professor
3-D structure of proteins: immunoglobulins and other binding proteins; ATP synthase; monoxygenases and dioxygenases quinone reductase.
Marc M. Greenberg, Ph.D., Professor
Chemical and biochemical approaches to the study of DNA damage and repair, and their applications.
Carol Greider, Ph.D., Professor
Telomerase and telomere length regulation.
Richard L. Huganir, Ph.D., Professor
Molecular mechanisms in the regulation of synaptic plasticity.
John T. Isaacs, Ph.D., Professor
Anti-cancer drug development; Normal and malignant stem cell biology.
William B. Isaacs, Ph.D., Professor
Understanding the molecular genetic events responsible for initiation and progression of prostate cancer, with particular interest in inherited susceptibility to prostate cancer.
Elizabeth M. Jaffee, M.D., Professor
Analysis of antitumor immune responses against human tumors; identification of the targets of tumor-specific cytotoxic T cells.
Kenneth W. Kinzler, Ph.D., Professor
Molecular genetics of cancer, translational cancer research.
Mark Levis, M.D., Ph.D., Associate Professor
Targeting the FLT3 signaling pathway as a treatment for acute leukemia.
Paula M. Pitha-Rowe, Ph.D., Professor
Effects of viral infection on expression of cellular (cytokines and chemokines and their receptors) and viral (HIV-1, HHV-8) genes; targeted antiviral and anticellular therapy (gene transfer, ribozymes); breast cancer: role of c-erbB-2.
Stuart C. Ray, M.D., Professor
Computational immunovirology of chronic viral hepatitis.
Charles M. Rudin, M.D., Ph.D., Professor
Molecular mechanisms of apoptosis, roles of apoptosis in carcinogenesis and therapeutic resistance, novel therapeutic development in animal models of cancer.
Saraswati Sukumar, Ph.D., Professor
Molecular alterations in breast cancer.
Craig A. Townsend, Ph.D., Professor
Organic and bioorganic chemistry: biosynthesis of natural products and biomimetic synthesis; elucidation of protein function; molecular biology of secondary metabolism and engineering of biosynthetic systems to practical ends; study of the role and inhibition of fatty acid synthesis in human cancer, tuberculosis, and obesity.
Srinivasan Yegnasubramanian, M.D., Ph.D., Associate Professor
Understanding and exploiting alterations in the cancer genome and epigenome for development of biomarkers and therapeutics.
Bert Vogelstein, M.D., Professor
Molecular genetics of human cancer.