Department Affiliation: Primary: Medicine; Secondary: Pharmacology and Molecular Sciences
Degree: M.D., Johns Hopkins University
Rank: Associate Professor
Telephone Number: 410-550-4229
Fax Number: 410-550-6864
E-mail address: pyen3@jhmi.edu
Johns Hopkins Bayview Medical Center Address: Div. of Endocrinology, Dept. Medicine, 5200 Eastern Avenue, Mason F. Lord Bldg., Rm. 432, Baltimore, MD 21224
Molecular mechanisms of positive and negative transcriptional regulation by thyroid hormone receptors; cell signaling and cell cycle regulation by PI-3 kinase regulatory subunits; role of PI-3 kinase regulatory subunit inhibitors on cell proliferation and cancer.
We have had a long-standing interest in the molecular mechanisms of positive and negative regulation of gene transcription by thyroid hormone receptors. We are interested in the recruitment of specific co-factors to thyroid hormone response elements and concomitant changes in histone acetylation and methylation in the promoters of individual target genes and the entire genome. We also are interested in cell signaling and cell cycle regulation by PI-3 kinase regulatory subunits, particularly p55 PI3K. We also study the employment of PI-3 kinase regulatory subunit inhibitors as therapeutic agents against cell proliferation and cancer.
Representative Publications:
- Maruvada, P., Baumann, C.T., Hager, G.L., and Yen, P.M. Dynamic shuttling and intranuclear diffusion of nuclear hormone receptors, J. Biol. Chem. 278:12425-12432, 2003. Pub Med Reference
- Yen, P.M., Feng, X., Flamant, F., Chen, Y.D., Samarut, J., Refetoff, S., and Meltzer, P.S. Effects of hormonal status and thyroid hormone receptor (TR) isoforms on hepatic gene expression profiles in TR knockout mice, EMBO Reports 4:581-587, 2003. Pub Med Reference
- Maruvada, P., Dmitrieva, N.I., East-Palmer, J., and Yen P.M. Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity, Mol. Biol. Cell 15:1895-1903, 2004. Pub Med Reference
- Liu, Y., Ando, S., Xia, X., Yao, R.F., Kim, M., Fondell, J., and Yen, P.M. P62, a TFIIH subunit interacts with thyroid hormone receptors (TRs) and enhances T3-mediated transcription, Mol. Endocrinol. 19:879-884, 2005. Pub Med Reference
- Liu, Y., Xia, X., Fondell, J.D., and Yen, P.M. Thyroid hormone regulated genes have distinct patterns of co-activator recruitment and histone acetylation, Mol. Endocrinol. 20:483-490, 2006. Pub Med Reference
Other graduate programs in which Dr. Yen participates: None
