Department Affiliation: Oncology
Degree: Ph.D., Johns Hopkins University
Rank: Professor
Telephone Number: 410-955-2928
Fax Number: 410-955-0548
E-mail: kinzlke@jhmi.edu
School of Medicine Address: Room 588, Cancer Research Bldg., 1650 Orleans Street, Baltimore, MD 21231
Molecular genetics of human cancer
Dr. Kinzler’s laboratory has focused on the genetics of human cancer. They have identified a variety of genetic mutations that underlie cancer, including mutations of the APC pathway that appear to initiate the majority of colorectal cancers and IDH1/2 mutations that underlying many gliomas. In addition, they have developed a variety of powerful tools for analysis of expression and genetic alterations in cancer. Most recently, they have pioneered integrated whole genome analyses of human cancers through expression, copy number, and mutational analyses of all the coding genes in several human cancer types including colorectal, breast, pancreatic and brain. The identification of genetic differences between normal and tumor tissues provide new therapeutic targets, new opportunities for the early diagnosis of cancer, and important insights into the neoplastic process.
Representative Publications:
- Yan, H., Yuan, W., Velculescu, V.E., Vogelstein, B. and Kinzler, K.W. Allelic variation in human gene expression, Science 297:1143, 2002. Pub Med Reference
- Barber, T.D., Vogelstein, B., Kinzler, K.W. and Velculescu, V.E. Somatic Mutations of EGFR in Colorectal Cancers and Glioblastomas. New England Journal of Medicine 351: 2883, 2004. Pub Med Reference
- Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A., Powell, S.M., Riggins, G.J., Willson, J.K., Markowitz, S., Kinzler, K.W., Vogelstein, B. and Velculescu, V.E. High frequency of mutations of the PIK3CA gene in human cancers, Science 304:554, 2004. Pub Med Reference
- Peters, B.A., Diaz, L.A., Polyak, K., Meszler, L., Romans, K., Guinan, E.C., Antin, J.H., Myerson, D., Hamilton, S.R., Vogelstein, B., Kinzler, K.W. and Lengauer C. Contribution of bone marrow-derived endothelial cells to human tumor vasculature, Nature Medicine 3:261-262, 2005. Pub Med Reference
- Sjöblom, T., Jones, S., Wood, L.D., Parsons, D.W., Lin, J., Barber, T., Mandelker, D., Leary, R.J., Ptak, J., Silliman, N., Szabo, S., Buckhaults, P., Farrell, C., Meeh, P., Markowitz, S.D., Willis, J., Dawson, D., Willson, J.K.V., Gazdar, A.F., Hartigan, J., Wu, L., Liu, C., Parmigiani, G., Park, B.H., Bachman, K.E., Papadopoulos, N., Vogelstein, B., Kinzler, K.W. and Velculescu, V.E. The Consensus Coding Sequences of Human Breast and Colorectal Cancers. Science 314: 268-274, 2006. Pub Med Reference
- Wood, L.D., Leary, R,J., Shen, D., Boca, S.M., Barber, T., Ptak, J., Silliman, N., Szabo, S., Dezso, Z., Ustyanksky, V., Nikolskaya, T., Nikolsky, T., Karchin, R., Wilson, P.A., Kaminker, J.A., Zhang, Z., Croshaw, R., Willis, J., Dawson, D., Shipitsin, M., Willson, J.K.V., Sukumar, S., Polyak, K., Park, B.H., Pethiyagoda, C.L., Pant, P.V.K., Ballinger, D.G., Sparks, A.B., Hartigan, J., Smith, D. R., Suh, E., Papadopoulos, N., Buckhaults, P., Markowitz,S.D., Parmigiani, G., Kinzler, K.W., Velculescu, V.E. and Vogelstein, B. The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113, 2007. Pub Med Reference
- Jones, S., Zhang, X., Parsons, D.W., Lin, J.C., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., Hong, S.M., Fu, B., Lin, M.T., Calhoun, E.S., Kamiyama, M., Walter, K., Nikolskaya, T., Nikolsky, Y., Hartigan, J., Smith, D.R., Hidalgo, M., Leach, S.D., Klein, A.P., Jaffee, E.M., Goggins, M., Maitra, A., Iacobuzio-Donahue, C., Eshleman, J.R., Kern, S.E., Hruban, R.H., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V.E. and Kinzler, K.W. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses. Science 321: 1801-1806, 2008. Pub Med Reference
- Parsons, D.W., Jones, S., Zhang, X., Lin, J.C., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.M., Gallia, G.L., Olivi, A., McLendon, R., Rasheed, B.A., Keir, S., Nikolskaya, T., Nikolsky, Y., Busam, D.A., Tekleab, H., Diaz, L.A., Jr., Hartigan, J., Smith, D.R., Strausberg, R.L., Marie, S.K., Shinjo, S.M., Yan, H., Riggins, G.J., Bigner, D.D., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V.E., and Kinzler, K.W. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812, 2008. Pub Med Reference
- He, Y., Vogelstein, B., Velculescu, V.E., Papadopoulos, N. and Kinzler, K.W. The Antisense Transcriptomes of Human Cells. Science 322: 1855-1857, 2008. Pub Med Reference
- Parmigiani, G., Boca, S., Lin, J., Kinzler, K.W., Velculescu, V., and Vogelstein, B. Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics 93, 17-21, 2009. Pub Med Reference
- Yan, H., Parsons, W., Jin, G., McLendon, R., Rasheed, A.B., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G.J., Friedman, H., Friedman, A., Reardon, D., Herndon, J., Kinzler, K.W., Velculescu, V.E., Vogelstein, B., and Bigner, D.D. IDH1 and IDH2 Mutations in Gliomas. NEJM 360, 765-773, 2009. Pub Med Reference
Other graduate programs in which Dr. Kinzler participates:
