Department Affiliation: Primary: Medicine, Division of Clinical Pharmacology; Secondary: Pharmacology and Molecular Sciences, Division of Infectious Diseases, Epidemiology, Bloomberg School of Public Health
Degree: M.D., Georgetown University School of Medicine
Rank: Associate Professor
Telephone Number: 410-955-9707
Fax Number: 410-955-9708
E-mail address: chendrix@jhmi.edu
School of Medicine Address: Room 502 Harvey, 600 N. Wolfe Street, Baltimore, MD 21287
Current research focuses on chemoprevention of infectious diseases
Research focuses on clinical pharmacology of HIV chemoprevention with an emphasis on: (1) development of methods to assess distribution of topical HIV microbicides, CD4 cells, and HIV in the sites of sexual transmission; (2) PK-PD models of pre-exposure antiretroviral HIV prophylaxis; (3) development of methods to understand the compartmentalization of antiretroviral drugs and HIV within the male genital tract. Other research involves HIV pharmacology, fungal chemoprevention, and drug-drug interactions.
Representative Publications:
- Ndovi TT, Choi L, Caffo B, Parsons T, Baker S, ZhaoM, Rohde C, Hendrix CW. Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a non-invasive method. Clin Pharmacol Ther 2006;80(2):146-158. Pub Med Reference
- Ndovi TT, Parsons T, Choi L, Caffo B, Rohde C, Hendrix CW. A New Method to Quantitatively Estimate Seminal Vesicle and Prostate Gland Contributions to Ejaculate. Br J Clin Pharmacol 2007;63(4):404-20. Epub 2006 Oct 31. Pub Med Reference
- Fuchs EJ, Lee LA, Torbenson MS, Parsons TL, Bakshi RP, Guidos AM, Wahl RL, Hendrix CW. Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV Transmission. J Infect Dis 2007;195(5):703-710. Epub 2007 Jan 23. Pub Med Reference
- Hendrix CW, Fuchs EJ, Macura KJ, Lee LA, Parsons TL, Bakshi RP, Khan WA, GuidosA, Leal JP, Wahl R. Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Clin Pharmacol Ther 2008 Jan; 83(1): 97-105. Epub 2007 May 16. Pub Med Reference
- Choi L, Caffo BS, Rohde C, Ndovi TT, Hendrix CW. A Mechanistic Latent Variable Model for Estimating Drug Concentrations in the Male Genital Tract: A Case Study in Drug Kinetics. Stat Med 2007 Oct 22;[Epub ahead of print] Pub Med Reference
- Cao YJ, Ndovi TT, ParsonsTL, Guidos A, Caffo B, Hendrix CW. Effect of semen sampling frequency on seminal antiretroviral drug concentration. Clin Pharmacol Ther 2008 Jun; 83(6):848-56. Epub 2007 Oct 3. Pub Med Reference
- Cao Y-J, Hendrix CW. Male Genital Tract Pharmacology: Developments in Quantitative Methods to Better Understand a Complex Peripheral Compartment. Clin Pharmacol Ther. 2008 Mar;83(3):401-12. Epub 2007 Oct 5. Pub Med Reference
- Cao YJ, Caffo B, Choi L, Radebaugh C, Fuchs EJ, Hendrix CW. Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin. J Clin Pharmacol. 2008 Feb;48(2):176-83. Epub 2007 Dec19. Pub Med Reference
- Nimmagadda S, Fuchs EF, Cao YJ, Louissaint N, Bakshi R, Guidos A, Menendez F, Purdy E, Lee L, King K, Hendrix CW. Autologous Lymphocytes and HIV-Sized Particles in Autologous Seminal Plasma Penetrate Colonic Tissue Following Simulated Receptive Anal Intercourse In Healthy Men.4th IAS Conference on HIV Pathogenesis, Treatment, and Prevention. Sydney, July 22-25 2007. Abstract WEPEA112.
- Cao YJ, Caffo BS, Fuchs EJ, Lee LA, Parsons TL,. Bakshi RP, Khan WA, Wahl R, Hendrix CW. Three-Dimensional SPECT/CT Curve Fitting Algorithm With Local Density Distribution Compared To Direct Methods For Quantitation Of The Distribution Of Rectally-Applied HIV-Sized Particles. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Orlando, FL, April 2008. (Abstract PIII-03)
