Ying-Jun Cao

Department Affiliation: Primary: Medicine, Division of Clinical Pharmacology; Secondary: Pharmacology and Molecular
Sciences
Degree: M.B., Nanhua University School of Medicine; Ph.D., Johns Hopkins University Bloomberg School of Public Health
Rank: Assistant Professor
Telephone Number: 410-955-3252
Fax Number: 410-614-9978
E-mail address:  ycao3@jhmi.edu
School of Medicine Address: 600 N. Wolfe Street, Osler 501, Baltimore, MD 21287-5554 

Pharmacokinetic and pharmacodynamic modeling of drug action at cellular, tissue, and population level; chemoprevention of HIV transmission; pharmacology of the male genital tract; clinical development of antiviral drugs

We are interested in modeling approaches for efficient development of drugs. We develop these approaches by combining pharmacological principles and statistics. The pharmacological component includes the spatial distribution of drugs; the statistical component includes the models that can summarize drug movement and drug action at the population level. Projects include pharmacokinetic-pharmacodynamic modeling for HIV chemoprevention trials and quantification of drugs/pathogens in accessory glands of the male genital tract.

Representative Publications:

• Cao Y.J. and Peng, Y.Y.  Activation of nicotinic receptor-induced postsynaptic responses to luteinizing hormone-releasing hormone in bullfrog sympathetic ganglia via a Na₊-dependent mechanism, Proc Natl Acad Sci USA 95:12689-12694, 1998.  Pub Med Reference
  

• Cao Y.J., Dreixler, J.C., Roizen, J.D., Michael, T.R., and Houamed, K.M. Modulation of recombinant small-conductance Ca²⁺-activated K⁺ channels by the muscle relaxant chlorzoxazone and structurally related compounds,  J Pharmacol Exp Ther 296:683-689, 2001.  Pub Med Reference

• Cao Y.J., Surowy, C.S., and Puttfarcken, P.S.  Nicotinic acetylcholine receptor-mediated [³H]-dopamine release from hippocampus, J Pharmacol Exp Ther 312:1298-12304, 2005.  Pub Med Reference

• Cao, Y.J., Mager, D.E., Simonsick, E.M., Hilmer, S.N., Ling, S.M., Windham, B.G., Crentsil, V., Yasar, S., Fried, L.P., and Abernethy, D.R. Physical and cognitive performance and burden of anticholinergics, sedatives and ACE inhibitors in older women, Clin Pharmacol Ther 83:422-429, 2008.  Pub Med Reference

• Cao Y.J., Ndovi, T.T., Parsons, T.L., Guidos, A., Caffo, B., and Hendrix, C.W. Effect of semen sampling frequency on seminal antiretroviral drug concentration, Clin Pharmacol Ther Oct 3, 2007.  Pub Med Reference

• Cao, Y.J., and Hendrix, C.W. Male genital tract pharmacology: developments in quantitative methods to better understand a complex peripheral compartment, Clin Pharmacol Ther 83:401-412, 2007.  Pub Med Reference

• Cao, Y.J., Flexner, C.W., Dunaway, S., Park, J.G., Klingman, K., Wiggins, I., Conley, J., Radebaugh, C., Kashuba, A.D., Macfarland, R., Becker, S., Hendrix, C.W.  Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers.  Antimicrob Agents Chemother, Feb 19, 2008; [Epub ahead of print].  Pub Med Reference

Other graduate programs in which Dr. Cao participates: