- Redox enzymes: Lipoxygenase; quinone reductase; peptidyl hydroxylating monooxygenase; isoprene epoxy-carotenoid dioxygenases; ?eta-methyl acyl-CoA hydroxylase (Phythanic acid); MICAL (FAD hydroxylase); and Duox2.
- Phosphoryl transfer: Mitochondrial ATP-synthase; Nudix pyrophosphatases; E.coli ADP-ribosehydrolase; M. tuberculosis ADP-ribose hydrolase, E.coli GDP-mannose hydrolase; E.coli dihydroneopterin hydrolase; D.radiodurans CoA hydrolase; Trypanosome Cruzi farnesyl pyrophosphate synthase; human PI3K-alpha (phosphoinositide 3 kinase).
- Gabelli, S.B., McLellan, J.S., Montalvetti, A., Oldfield, E., Docamp, R., and Amzel, LM. Structure and mechanism of the farnesyl pyrophosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins 62 (1) : 80-88, 2006. (C) Pub Med Reference
- Muzammil S., Armstrong, A.A., Kang, L.W., Jakalian, A., Bonneau, R.P., Schmelmer, V., Amzel, L.M., Freire, E. Unique thermodynamic response of tipranutation of the HIV-1 protease drug resistance mutations. J. Virology 81 : 5144-54, 2007. Pub Med Reference
Lafont, V., Armstrong, A.A., Ohtaka, H., Kiso, Y., Amzel, L.M., and Freire, E. Compensating enthalpic and entropic changes hinder binding affinity optimization. Chem. Biol. Drug Des. 69(6) : 413-422, 2007. (C) Pub Med Reference
Bianchet, M.A., and Amzel, L.M., Making the right moves. Structures 15(8) : 885-6, 2007. Pub Med Reference
Parker, J.B., Bianchet, M.A., Krosky, D.J., Friedman, J.I., Amzel, L.M., and Stivers, J.T. Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature 449(7161) : 433-7, 2007.Pub Med Reference (C) Cover Illustration
Other graduate programs in which Dr. Amzel participates: BCMB Program
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