Department Affiliation: Primary: Oncology; Secondary: Pharmacology and Molecular Sciences; Pathology
Degree: M.D., Ph.D. Johns Hopkins University
Rank: James B. Murphy Professor
Telephone Number: 410-955-8839
Fax Number: 410-955-0960
E-mail address: ambinri@jhmi.edu
School of Medicine Address: Room 389, Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231
Virology in human cancer; antiviral therapy; antitumor therapy; lymphoma biology
Epstein-Barr virus is consistently found in association with a variety of cancers including lymphoid and epithelial malignancies. Our laboratory studies are aimed at better defining the role(s) of the virus in the pathogenesis of these diseases and the development of strategies to prevent, diagnose or treat them. Among the notions that we are exploring is the possibility that activation of virus-encoded enzymes will allow the targeted delivery of radation. In addition we are investigating viral DNA in serum and plasma and the possible role in early diagnosis and disease monitoring.
Representative Publications:
- Jones, R.J., Gocke, C.D., Kasamon, Y.L., Miller, C.B., Perkins, B., Barber, J.P., Vala, M.S., Gerber, J.M., Gellert, L.L., Siedner, M., Lemas, M.V., Brennan, S., Ambinder, R.F., Matsui, W. Circulating clonotypic B cells in classic Hodgkin lymphoma. Blood 113(23):5920-5926, 2009. Pub Med Reference
- Fu, D.X., Tanhehco, Y., Chen, J., Foss, C.A., Fox, J.J., Chong, J.M., Hobbs, R.F., Fukayama, M., Sgouros, G., Kowalski, J., Pomper, M.G., Ambinder, R.F. Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors. Nat. Med. 14(10):1118-1122, 2008. Pub Med Reference.
- Spitzer, T.R., Ambinder, R.F., Lee, J.Y., Kaplan, L.D., Wachsman, W., Straus, D.J., Aboulafia, D.M., Scadden, D.T. Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant 14(1):59-66, 2008. Pub Med Reference
- Ambinder, R.F., Lin, L. Mononucleosis in the laboratory. J. Infect. Dis. 192(9):1503-1504, 2005. PubMed Reference
- Glaser, S.L., Keegan, T.H., Clarke, C.A., Trinh, M., Dorfman, R.F., Mann, R.B., DiGiuseppe, J.A., Ambinder, R.F. Exposure to childhood infections and risk of Epstein-Barr virus--defined Hodgkin's lymphoma in women. Int. J. Cancer. 115(4):599-605, 2005. Pub Med Reference
Keegan, T.H., Glaser, S.L., Clarke, C.A., Gulley, M.L., Craig, F.E., Digiuseppe, J.A., Dorfman, R.F., Mann, R.B., Ambinder, R.F. Epstein-Barr virus as a marker of survival after Hodgkin's lymphoma: a population-based study. J. Clin. Oncol. 23(30):7604-7613, 2005. Review. Pub Med Reference.
Chan, A.T., Tao, Q., Robertson, K.D., Flinn, I.W., Mann, R.B., Klencke, B., Kwan, W.H., Leung, T.W., Johnson, P.J., Ambinder, R.F. Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors. J Clin Oncol. 22(8):1373-1381, 2004. Pub Med Reference.
- Fu, D.X., Tanhehco, Y.C., Chen, J., Foss, C.A., Fox, J.J., Lemas, V., Chong, J.M., Ambinder, R.F., Pomper, M.G. Virus-associated tumor imaging by induction of viral gene expression. Clin. Cancer Res. 13(5):1453-1458, 2007. Pub Med Reference
- Glaser, S.L., Keegan, T.H., Clarke, C.A., Darrow, L.A., Gomez, S.L., Dorfman, R.F., Mann, R.B., DiGiuseppe, J.A., Ambinder, R.F. Smoking and Hodgkin lymphoma risk in women United States. Cancer Causes Control 15(4):387-397, 2004. Pub Med Reference
- Glaser, S.L., Clarke, C.A., Gulley, M.L., Craig, F.E., DiGiuseppe, J.A., Dorfman, R.F., Mann, R.B., Ambinder, R.F. Population-based patterns of human immunodeficiency virus-related Hodgkin lymphoma in the Greater San Francisco Bay Area, 1988-1998. Cancer 98(2):300-309, 2003. Pub Med Reference
Other graduate programs in which Dr. Ambinder participates:
BCMB Program
Cellular and Molecular Medicine Graduate Program
Anti-Cancer Drug Development Program
