Human melanocyte growth and differentiation, molecular regulation of melanoma development and progression, targeted therapies for melanoma, molecular diagnostics for melanoma.
Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment; immunological approaches to virus-associated malignancies.
L. Mario Amzel, Ph.D., Professor
3-D structure of proteins: immunoglobulins and other binding proteins; ATP synthase; monoxygenases and dioxygenases quinone reductase.
J. Thomas August, M.D., Professor
Genetic immunotherapy of infectious diseases and cancer by targeting DNA encoded antigen chimeras to MHC II; MHC II antigen presentation; development of DNA vaccines; immune tolerance.
Philip Cole M.D., Ph.D., Professor and Director
Chemical and biochemical approaches in the study of signal transduction, circadian rhythm, and gene regulation.
Robert J. Cotter, Ph.D., Professor
Development of new analytical techniques and instrumentation for mass spectrometry; applications of mass spectrometry to the structural analysis of peptides, glycopeptides, and glycolipids.
Samuel R. Denmeade, M.D., Associate Professor
Targeted therapies for cancer; prodrugs; proteases; peptide libraries.
Robert H. Getzenberg, Ph.D., Professor
Cancer biomarkers; proteomic analysis of nuclear structure; field effects in cancer.
Wade Gibson, Ph.D., Professor
Herpesvirus proteins: studies of their expression, structure, and function using genetic, biochemical, and immunological approaches.
Carol Greider, Ph.D., Professor
Telomerase and telomere length regulation.
Gary S. Hayward, Ph.D., Professor
Pathways of herpesvirus gene regulation and latency; cis-acting DNA elements that modulate gene expression; mechanisms of positive and negative transcriptional regulation by viral and cellular transactivators; nuclear oncogenes; Kaposi's sarcoma herpesvirus.
S. Diane Hayward, Ph.D., Professor
Epstein-Barr virus; viral latency and B-cell immortalization; DNA-binding proteins in regulation of viral gene expression; mechanisms of virus-induced cell proliferation; notch signaling pathway.
William B. Isaacs, Ph.D., Professor
Understanding the molecular genetic events responsible for initiation and progression of prostate cancer, with particular interest in inherited susceptibility to prostate cancer.
Elizabeth M. Jaffee, M.D., Professor
Analysis of antitumor immune responses against human tumors; identification of the targets of tumor-specific cytotoxic T cells.
Thomas W. Kensler, Ph.D., Professor
Mechanisms of cancer chemoprevention.
Kenneth W. Kinzler, Ph.D., Professor
Molecular genetics of cancer, particularly colorectal cancer and familial adenomatous polyposis.
Jun Liu, Ph.D., Professor
Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation.
Caren L. Freel Meyers, Ph.D., Assistant Professor
Organic and medicinal chemistry, chemical biology: drug delivery mechanisms in bacteria; development of antibiotic prodrug strategies; study of bacterial isoprenoid biosynthesis; combinatorial biosynthesis; development of potential therapeutic agents.
William G. Nelson, M.D., Ph.D., Professor
Molecular mechanisms of prostatic carcinogenesis; epigenetic alterations in cancer; new approaches to prostate cancer prevention and treatment.
Paula M. Pitha-Rowe, Ph.D., Professor
Effects of viral infection on expression of cellular (cytokines and chemokines and their receptors) and viral (HIV-1, HHV-8) genes; targeted antiviral and anticellular therapy (gene transfer, ribozymes); breast cancer: role of c-erbB-2.
Martin G. Pomper, M.D., Ph.D., Associate Professor
In Vivo molecular and cellular imaging; radiopharmaceutical development; targeted cancer imaging and therapy; functional brain imaging.
Gary H. Posner, Ph.D., Professor
Organic and medicinal chemistry aimed toward rational design and synthesis of new compounds for effective and safe chemotherapy of malaria and cancer.
Jonathan D. Powell, M.D., Ph.D., Assistant Professor
Mechanisms of T cell activation and tolerance.
Douglas N. Robinson, Ph.D., Assistant Professor
Understanding cytokinesis and cell shape control.
Charles M. Rudin, M.D., Ph.D., Associate Professor
Molecular mechanisms of apoptosis; roles of apoptosis in carcinogenesis and therapeutic resistance; novel therapeutic development in animal models of cancer.
Ronald L. Schnaar, Ph.D., Professor
Cell interactions in the nervous system.
James Stivers, Ph.D., Associate Professor
Molecular mechanism and inhibition of enzymes involved in DNA and RNA metabolism.
Paul Talalay, M.D., Professor
Molecular mechanisms involved in chemoprotection against mutagens and carcinogens; catalytic mechanism of the enzymatic transformations of steroid hormones.
Sean D. Taverna, Ph.D., Assistant Professor
Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.
Craig A. Townsend, Ph.D., Professor
Organic and bioorganic chemistry: biosynthesis of natural products and biomimetic synthesis; protein isolation and mechanistic enzymology; molecular biology of secondary metabolism and the applications of biosynthetic systems; study of the role and inhibition of fatty acid synthesis in human cancer and tuberculosis.
Bert Vogelstein, M.D., Professor
Molecular genetics of human cancer.
Jin Zhang, Ph.D., Assistant Professor
Cell signaling; kinases and phosphatases; chemotaxis; live-cell imaging; fluorescent proteins and reporters; chemical Biology.
Heng Zhu, Ph.D., Assistant Professor
Signal Transduction, protein network, host-pathogen interaction, protein chip approach to study proteomics
