330.710 Mechanisms in Bioorganic Chemistry
2008 Mechanisms in Bioorganic Chemistry - Pharmacology (ME.330.710)
April 17, 21, 23, 25, 29
May 1, 5, 7, 9, 13, 15
9:00 - 10:30 A.M.
303 Wood Basic Science Building (Abel Library)
Caren Meyers & James Stivers, Course Directors
Schedule as of 3/31/08
This course deals with the mechanisms of action of enzymes, and is intended to introduce some of the basic principle of catalysis and illustrate how our knowledge of organic reaction mechanisms can help in interpreting enzyme-catalyzed processes.
| 17-Apr-2008 | Thu | Intramolecularity in Catalysis and Ligand Design | STIVERS |
| 21-Apr-2008 | Mon | Carboxylases/Aldolases: Carbon-Carbon Bond Formation I | MILDVAN |
| 23-Apr-2008 | Wed | Proteases II | LIU |
| 25-Apr-2008 | Fri | Phosphoryl Transfer II | COLE |
| 29-Apr-2008 | Tue | Pantothenic Acid: Fatty Acid and Polyketide Synthesis | MEYERS |
| 1-May-2008 | Thu | EXAM 1 (TBA) 9:00 - 11:00 | |
| 5-May-2008 | Mon | Drug Design | LIU |
| 7-May-2008 | Wed | Cytochrome P450 Enzymes | COLE |
| 9-May-2008 | Fri | How Enzymes Deprotonate Carbon | MILDVAN |
| 13-May-2008 | Tue | Coenzyme B12 Transformations | MILDVAN |
| 15-May-2008 | Thu | EXAM 2 (TBA) 9:00 - 11:00 |
| COURSE FACULTY | |||
| Dr. P. Cole | 316 Hunterian | x4-0540 | pcole@jhmi.edu |
| Dr. J. Liu | 516 Hunterian | x5-4619 | joliu@jhu.edu |
| Dr. Caren Meyers | 307-A WBSB | x2-4807 | cmeyers8@jhmi.edu |
| Dr. A.S. Mildvan | 511 Hunterian | x5-2038 | mildvan@jhmi.edu |
| Dr. J.T. Stivers | 314 WBSB | x2-2758 | jstivers@jhmi.edu |
Recommended Textbooks
There is no required text for the course, but if students would like to purchase a single helpful textbook, #1 by Tim Bugg would be the best choice.
- An Introduction to Enzymes and Coenzyme Chemistry by Tim Bugg, Blackwell Science (1997) ~$49.95. ISBN: 0-86542-793-3
- Principles of Bioinorganic Chemistry by Stephen J. Lippard and Jeremy Berg, University Science Books (1994) ~$58.50. ISBN: 0-93570-272-5
- Structure and Mechanisms in Protein Science by Alan Fersht, W.H. Freeman and Co.
(1999), approximately ~$90.00. ISBN: 0-71673-268-8 - The Organic Chemistry of Biological Pathways by John McMurry and Tadhg Begley,
Robert & Company (2005) ~$89.00. ISBN: 0-97470-771-6
*Please click here for Homework Answer Keys.
