330.709 Organic Mechanisms in Biology
2009-2010 Organic Mechanisms in Biology- Pharmacology (ME.330.709)
Wednesday / Friday: November 18, 2009 - January 28, 2010
9:00 A.M. - 10:30 A.M.
Wood Basic Science Lecture Hall (Ground Floor)
James Stivers, Course Director
Schedule as of 9/23/09
This course deals with the chemical mechanisms of enzymes. It is intended to illustrate how catalysis in biological systems can be understood using principles derived from organic reaction mechanisms.
18-Nov-2009 | Wed | Introduction to Organic Mechanisms in Biology | STIVERS |
20-Nov-2009 | Fri | The Energetics of Enzymatic Catalysis I | STIVERS |
25-Nov-2009 | Wed | The Energetics of Enzymatic Catalysis II | STIVERS |
2-Dec-2009 | Wed | Useful Methods in Bioorganic Chemistry | STIVERS |
*4-Dec-2009 | Fri | Proteases I | LIU |
9-Dec-2009 | Wed | Pyridoxal Requiring Reactions | STIVERS |
11-Dec-2009 | Fri | Metals in Enzyme Catalysis | MILDVAN |
16-Dec-2009 | Wed | Thiamin Requiring Reactions | STIVERS |
18-Dec-2009 | Fri | EXAM 1 (TBA) | |
6-Jan-2010 | Wed | Glycosyl Transfer | STIVERS |
*8-Jan-2010 | Fri | Phosphoryl Transfer | COLE |
13-Jan-2010 | Wed | Biological Oxidation and Reduction: | AMZEL |
15-Jan-2010 | Fri | Nucleic Acids | MILLER |
20-Jan-2010 | Wed | Side Chain Derived Cofactors (GFP, others) | ZHANG |
22-Jan-2010 | Fri | Tetrahydrofolate (FH4) Dependant One Carbon Transfer Reactions | STIVERS |
25-Jan-2010 | Mon | Reversible Methylation in Biology: SAM Dependent Methylation Reactions and Nonoxidative/Oxidative Demethylases | STIVERS |
28-Jan-2010 | Thu | EXAM 2 (TBA) |
*Core Discussions, Dec. 4 and Jan. 8 (Time/Location TBA)
| Course Faculty | |||
Dr. M. Amzel | 615 WBSB | x4-3955 | mario@neruda.med.jhmi.edu |
| Dr. P. Cole | 316 Hunterian | x4-0540 | pcole@jhmi.edu |
| Dr. J. Liu | 516 Hunterian | X5-4619 | joliu@jhu.edu |
| Dr. A.S. Mildvan | 511 Hunterian | x5-2038 | mildvan@jhmi.edu |
| Dr. P.S. Miller | 3116 Hyg.-West | X5-3489 | pmiller@jhsph.edu |
| Dr. J.T. Stivers | 314 WBSB | x2-2758 | jstivers@jhmi.edu |
| Dr. J Zhang | 305 Hunterian | x2-0173 | jzhang32@jhmi.edu |
HELPFUL TEXTBOOKS (none required)
1. The Organic Chemistry of Biological Pathways by John McMurry and Tadhg Begley, Robert
& Company (2005) ~$89.00. ISBN: 0-9747077-1-6
2. An Introduction to Enzymes and Coenzyme Chemistry by Tim Bugg, Blackwell Science
(1997) ~$49.95. ISBN: 0-86542-793-3
3. Principles of Bioinorganic Chemistry by Stephen J. Lippard and Jeremy Berg, University
Science Books (1994) ~$58.50. ISBN: 0-93570-272-5
4. Nucleic Acids in Chemistry and Biology by G. Michael Blackburn and Michael G. Gait,
Oxford (1996) ~$59.95. ISBN: 0-19963-533-1
5. Structure and Mechanisms in Protein Science by Alan Fersht, W.H. Freeman and Co.
(1999) ~$90.00. ISBN: 0-71673-268-8
