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Publications

Leyan Xu, David Ryugo, Tan Pongstaporn, Karl Johe, and Vassilis Koliatsos (2009) Human Neural Stem Cell Grafts in the Spinal Cord of SOD1 Transgenic Rats: Differentiation and Structural Integration into the Segmental Motor Circuitry. Journal of Comparative Neurology 514:297-309.
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David K. Ryugo and G.A. Spirou (2009) Auditory System: Giant Synaptic Terminals, Endbulbs and Calyces. In: New Encyclopedia of Neuroscience, Vol. 1 (ed. L.R. Squire). Academic Press, Oxford, pp. 759-770.
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Maria E. Rubio, K.A. Gudsnuk, Y. Smith, and D.K. Ryugo
(2008) Revealing the molecular layer of the primate dorsal cochlear nucleus. Neuroscience doi:10.1016/j.neuroscience.2007.12.016
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David K. Ryugo (2007) Projections of low spontaneous rate, high threshold auditory nerve fibers to the small cell cap of the cochlear nucleus in cats. Neuroscience doi:10.1016/j.neuroscience.2007.10.052
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James S. Kehler, V.A. David, A.A. Schäffer, K. Bajema, E. Eizirik, D.K. Ryugo, S.S. Hannah, S.J. O'Brien, and M. Menotti-Raymond (2007) Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats. Journal of Heredity 98:555-66.
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Zhan, Xiping, and D.K. Ryugo (2007) Projections of the lateral reticular nucleus to the cochlear nucleus in rats. Journal of Comparative Neurology 504:583-598.
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Eisen, Marc D., and D.K. Ryugo (2007) Hearing molecules: contributions from genetic deafness. Cellular and Molecular Life Sciences 64:566-580.
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Stamataki, Sofia, H.W. Francis, M. Lehar, B.J. May, D.K. Ryugo. (2006) Synaptic alterations at inner hair cells precede spiral ganglion cell loss in aging C57BL/6J mice. Hearing Research 221:104-118.
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Zhan, Xiping, T. Pongstaporn, and D.K. Ryugo (2006) Projections of the second cervical dorsal root ganglion to the cochlear nucleus in rats. Journal of Comparative Neurology 496:335-348.
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Meltzer, Noah E., and D.K. Ryugo (2006) Projections from auditory cortex to cochlear nucleus: a comparative analysis of rat and mouse. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 288A:397-408.
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Doucet, John R., and D.K. Ryugo (2006) Structural and functional classes of multipolar cells in the ventral cochlear nucleus. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 288A:331-344.
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Ryugo, David K., K.L. Montey, A.L. Wright, M.L. Bennett, and T. Pongstaporn (2006) Postnatal development of a large auditory nerve terminal: The endbulb of Held in cats. Hearing Research 216-217:100-115.
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Francis, Howard W., A. Rivas , M. Lehar, Y. Saito, P.R. Mouton, D.K. Ryugo (2006)
Efficient quantification of afferent cochlear ultrastructure using design-based stereology. Journal of Neuroscience Methods 150:150-158.
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Friedland, David R., J.G. Los, D.K. Ryugo (2006)
A modified Golgi staining protocol for use in the human brain stem and cerebellum. Journal of Neuroscience Methods 150:90-95.
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Ryugo, David K., E.A. Kretzmer, J.K. Niparko (2005)
Restoration of auditory nerve synapses in cats by cochlear implants. Science 310:1490-1492.
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Haenggeli, Charles-André, T Pongstaporn, JR Doucet, DK Ryugo (2005)
Projections from the spinal trigeminal nucleus to the cochlear nucleus in the rat. Journal of Comparative Neurology 484:191-205.
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Xu, S., Y. Wang, H. Zhao, L. Zhang, W. Xiong, K.W. Yau, H. Hiel, E. Glowatzki, D.K. Ryugo, and D. Valle (2004)
PHR1, a PH domain-containing protein expressed in primary sensory neurons. Molecular and Cellular Biology 24:9137-9151.
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Francis, Howard W., A. Rivas, M. Lehar, and D.K. Ryugo (2004)
Two types of afferent terminals innervate cochlear inner hair cells in C57BL/6J mice. Brain Research 1016:182-194.
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Kretzmer, Erika A., N.E. Meltzer, C-A Haenggeli, and D.K. Ryugo (2004)
An animal model for cochlear implants. Archives of Otolaryngology--Head & Neck Surgery 130:499-508.
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Lee, Daniel J., H.B. Cahill, and D.K. Ryugo (2003)
Effects of congenital deafness in the cochlear nuclei of Shaker-2 mice: An ultrastructural analysis of synapse morphology in the endbulbs of Held. Journal of Neurocytology 32:229-243.
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Francis, Howard W., D.K. Ryugo, M.J. Gorelikow, C.A. Prosen, and B.J. May (2003)
The functional age of hearing loss in a mouse model of presbycusis. II. Neuroanatomical correlates. Hearing Research 183:29-36.
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Babalian, Alexander L., D.K. Ryugo, and E.M. Rouiller (2003)
Discharge properties of identified cochlear nucleus neurons and auditory nerve fibers in response to repetitive electrical stimulation of the auditory nerve. Experimental Brain Research 153:452-460.
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Ryugo, David K., C-A Haenggeli, and J.R. Doucet (2003b)
Multimodal inputs to the granule cell domain of the cochlear nucleus. Experimental Brain Research 153:477-485.
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Doucet, John R., D.L. Molavi, and D.K. Ryugo (2003)
The source of corticocollicular and corticobulbar projections in area Te1 of the rat. Experimental Brain Research 153:461-466.
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Ryugo, David K., H.B. Cahill, L.S. Rose, B.T. Rosenbaum, M.E. Schroeder, and A.L. Wright (2003a)
Separate forms of pathology in the cochlea of congenitally deaf white cats. Hearing Research 181:73-84.
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Ryugo, David K., and Thomas N. Parks (2003)
Primary innervation of the avian and mammalian cochlear nucleus. Brain Research Bulletin 60:435-456.
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Doucet, John R., and D.K. Ryugo (2003)
Axonal pathways to the lateral superior olive labeled with biotinylated dextran amine injections in the dorsal cochlear nucleus of rats. Journal of Comparative Neurology 461:452-465.
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Friedland, David R., T. Pongstaporn, J.R. Doucet, and D.K. Ryugo (2003)
Ultrastructural examination of the somatic innervation of ventrotubercular cells in the rat. Journal of Comparative Neurology 459:77-89.
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Redd, E.E., H.B. Cahill, T. Pongstaporn, and D.K. Ryugo (2002)
The effects of congenital deafness on auditory nerve synapses: Type I and type II multipolar cells in the anteroventral cochlear nucleus of cats. Journal of the Association for Research in Otolaryngology 3:403-417.
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Li, S., S.M. Price, H. Cahill, D.K. Ryugo, M.M. Shen, and M. Xiang (2002)
Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl 1 homeobox gene. Development and Disease 129:3523-3532.
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Babalian, A.L., A.V. Jacomme, J.R. Doucet, D.K. Ryugo, and E.M. Rouiller (2002)
Commissural glycinergic inhibition of bushy and stellate cells in the anteroventral cochlear nucleus. NeuroReport 13:555-558.
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Doucet, John R., L. Rose, and D.K. Ryugo (2002)
The cellular origin of corticofugal projections to the superior olivary complex in the rat. Brain Research 925:28-41.
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Limb, C.J., and D.K. Ryugo (2001)
Development of endbulbs of Held in mice.  In: Handbook of Mouse Auditory Research, (ed., J.F. Willott).  CRC Press, Boca Raton, FL, pp. 225-236.

Ohlrogge, M., J.R. Doucet, and D.K. Ryugo (2001)
Projections of the pontine nuclei to the cochlear nucleus of rats. Journal of Comparative Neurology 436:290-303.
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Wang, Y., D. Huso, H.B. Cahill, D.K. Ryugo, and J. Nathans (2001)
Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. Journal of Neuroscience 21:4761-4771.
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Ryugo, D.K., C.J. Limb, and E.E. Redd (2000)
Brain plasticity: The impact of the environment on the brain as it relates to hearing and deafness. In: Cochlear Implants: Principles and Practices, (eds., J.K. Niparko, et al.). Lippincott Williams & Wilkins, Philadelphia, PA, pp. 33-56.

Limb, C.J., and D.K. Ryugo (2000)
Development of primary axosomatic endings in the anteroventral cochlear nucleus of mice. Journal of the Association for Research in Otolaryngology 1:103-119.
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Redd, E.E., T. Pongstaporn, and D.K. Ryugo (2000)
The effects of congenital deafness on auditory nerve synapses and globular bushy cells in cats.  Hearing Research 147:160-174.
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Babalian, A.L., D.K. Ryugo, M.W. Vischer, and E.M. Rouiller (1999)
Inhibitory synaptic interactions between cochlear nuclei: Evidence from an in vitro whole brain study.  NeuroReport  10:1913-1917.
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Doucet, J.R., A.T. Ross, M.B. Gillespie, D.K. Ryugo (1999)
Glycine immunoreactivity of multipolar neurons in the ventral cochlear nucleus which project to the dorsal cochlear nucleus. Journal of Comparative Neurology 408:515-531.
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Sharp, A.H., F.C. Nucifora Jr., O. Blondel, C.A. Sheppard, C. Zhang, S.H. Snyder, J.T. Russell, D.K. Ryugo, and C.A. Ross (1999)
Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain. Journal of Comparative Neurology 406:207-220.
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Ryugo, D.K., B.T. Rosenbaum, P.J. Kim, J.K. Niparko, and A.A. Saada (1998)
Single unit recordings in the auditory nerve of congenitally deaf white cats: Morphological correlates in the cochlea and cochlear nucleus. Journal of Comparative Neurology 397:532-548.
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Doucet, J.R., and D.K. Ryugo (1997)
Projections from the ventral cochlear nucleus to the dorsal cochlear nucleus in rats. Journal of Comparative Neurology 385:245-264.
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Ryugo, D.K., T. Pongstaporn, D.M. Huchton, and J.K. Niparko (1997)
Ultrastructural analysis of primary endings in deaf white cats: Morphologic Alterations in Endbulbs of Held. Journal of Comparative Neurology 385:230-244.
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Huchton, D.M., T. Pongstaporn, J.K. Niparko, and D.K. Ryugo (1997)
Ultrastructural changes in primary endings of deaf white cats. Otolaryngology—Head and Neck Surgery 116:286-293.
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Ryugo, D.K. and S. Sento (1996)
Auditory nerve terminals and cochlear nucleus neurons: Endbulbs of Held and spherical bushy cells. In: Advances in Speech, Hearing and Language Processing, (series ed. W.A. Ainsworth). JAI Press, Greenwich, CT, pp. 19-40.

Lee, S., D.W. Eisele, A.R. Schwartz, and D.K. Ryugo (1996)
Peripheral course of genioglossal motor axons within the hypoglossal nerve of the rat. Laryngoscope 106:1274-1279.
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Saada, A.A., J.K. Niparko, and D.K. Ryugo (1996)
Morphological changes in the cochlear nucleus of congenitally deaf white cats. Brain Research 736:315-328.
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Weedman, D.L. and D.K. Ryugo (1996b)
Projections from auditory cortex to the cochlear nucleus in rats: synapses on granule cell dendrites. Journal of Comparative Neurology 371:311-324.
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Gates, T.S., D.L. Weedman, T. Pongstaporn, and D.K. Ryugo (1996)
Immunocytochemical localization of glycine in a subset of cartwheel cells of the dorsal cochlear nucleus in rats. Hearing Research 96:157-166.
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Weedman, D.L., and D.K. Ryugo (1996a)
Pyramidal cells in primary auditory cortex project to cochlear nucleus in rat. Brain Research 706:97-102.
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Wright, D.D., and D.K. Ryugo (1996)
Mossy fiber projections from the cuneate nucleus to the cochlear nucleus in the rat. Journal of Comparative Neurology 365:159-172.
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Weedman, D.L., Tan Pongstaporn, and D.K. Ryugo (1996)
Ultrastructural study of the granule cell domain of the cochlear nucleus in rats: mossy fiber endings and their targets. Journal of Comparative Neurology 369:345-360.
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Ryugo, D.K., M.M. Wu, and T. Pongstaporn (1996)
Activity-related features of sypnapse morphology: A study of endbulbs of Held. Journal of Comparative Neurology 365:141-158.
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Wright, D.D., C.D. Blackstone, R.L. Huganir, and D.K. Ryugo (1996)
Immunocytochemical localization of the mGluR1. Metabotropic glutatmate receptor in the dorsal cochlear nucleus. Journal of Comparative Neurology 364:729-745.
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Ryugo, D.K., T. Pongstaporn, D.D. Wright, and A.H. Sharp (1995)
Inositol 1,4,5-Trisphosphate receptors: Immunocytochemical localization in the dorsal cochlear nucleus. Journal of Comparative Neurology 358: 102-118.
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Szpir, M.R., D.D. Wright, and D.K. Ryugo (1995)
Neuronal organization of the cochlear nuclei in alligator lizards: a light and electron microscopic investigation. Journal of Comparative Neurology 357:217-241.
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Sharp, A.H., S.J. Loev, G. Schilling, S-H Li, X-J Li, J. Bao, M.V. Wagster, J.A. Kotzuk, J.P. Steiner, A. Lo, J. Hedreen, S. Sisodia, S.H. Snyder, T.M. Dawson, D.K. Ryugo, and C.A. Ross (1995)
Widespread expression of Huntington's disease gene (IT15) protein product. Neuron 14:1065-1074.
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Morgan, Y.V., D.K. Ryugo, and M.C. Brown (1994)
Central trajectories of type II (thin) fibers of the auditory nerve in cats. Hearing Research 79:74-82.
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Manis, P.B., G.A. Spirou, D.D. Wright, S. Paydar, and D.K. Ryugo (1994)
Physiology and morphology of complex spiking neurons in the guinea pig dorsal cochlear nucleus. Journal of Comparative Neurology 348:261-276.
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Cunningham, A.M., D.K. Ryugo, A.H. Sharp, R.R. Reed, S.H. Snyder, and G.V. Ronnett (1993)
Neuronal inositol 1,4,5-triphosphate receptor localized to the plasma membrane of olfactory cilia. Neuroscience 57:339-352.
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Ryugo, D.K., D.D. Wright, and T. Pongstaporn (1993)
Ultrastructural analysis of synaptic endings of auditory nerve fibers in cats: Correlations with spontaneous discharge rate. In: The Mammalian Cochlear Nuclei: Organization and Function, (eds. M.A. Merchan et al.). Plenum Press, New York, NY, pp. 65-80.

Spirou, G.A., B.J. May, D.D. Wright, and D.K. Ryugo (1993)
Frequency organization of the dorsal cochlear nucleus in cats. Journal of Comparative Neurology 329:36-52.
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Ryugo, D.K. and S.K. May (1993)
The projections of intracellularly labeled auditory nerve fibers to the dorsal cochlear nucleus of cats. Journal of Comparative Neurology 329:20-35.
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Ryugo, D.K. (1992)
The auditory nerve: Peripheral innervation, cell body morphology, and central projections. In: Mammmalian Auditory Pathway: Neuroanatomy, (eds. D.B. Webster et al.). Springer-Verlag, New York, NY, pp. 23-65.

Ryugo, D.K., L.W. Dodds, T.E. Benson, and N.Y. Kiang (1991)
Unmyelinated axons of the auditory nerve in cats. Journal of Comparative Neurology 308:209-223.
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Berglund, A.M. and D.K. Ryugo (1991)
Neurofilament antibodies and spiral ganglion neurons of the mammalian cochlea. Journal of Comparative Neurology 306:393-408.
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Ryugo, D.K. and S. Sento (1991)
Synaptic connections of the auditory nerve in cats: Relationship between endbulbs of Held and spherical bushy cells. Journal of Comparative Neurology 305:35-48.
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Szpir, M.R., S. Sento, and D.K. Ryugo (1990)
Central projections of cochlear nerve fibers in the alligator lizard. Journal of Comparative Neurology 295:530-547.
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Sento, S. and D.K. Ryugo (1989)
Endbulbs of Held and spherical bushy cells in cats: Morphological correlates with physiological properties. Journal of Comparative Neurology 280:553-562.
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Brown, M.C., M.C. Liberman, T.E. Benson, and D.K. Ryugo (1988b)
Brainstem branches from olivocochlear axons in cats and rodents. Journal of Comparative Neurology 278:591-603.
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Brown, M.C., A.M. Berglund, N.Y. Kiang, and D.K. Ryugo (1988a)
Central trajectories of type II spiral ganglion neurons. Journal of Comparative Neurology 278:581-590.
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Ryugo, D.K., and E.M. Rouiller (1988)
Central projections of intracellularly labeled auditory nerve fibers in cats: morphometric correlations with physiological properties. Journal of Comparative Neurology 271:130-142.
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Berglund, A.M., and D.K. Ryugo (1987)
Hair cell innervation by spiral ganglion neurons in the mouse. Journal of Comparative Neurology 255:560-570.
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Berglund, A.M., and D.K. Ryugo (1986)
A monoclonal antibody labels type II neurons of the spiral ganglion. Brain Research 383:327-332.
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Rouiller, E.M., R. Cronin-Schreiber, D.M. Fekete, and D.K. Ryugo (1986)
The central projections of intracellularly labeled auditory nerve fibers in cats: an analysis of terminal morphology. Journal of Comparative Neurology 249:261-278.
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Ryugo, D.K., and F.H. Willard (1985)
The dorsal cochlear nucleus of the mouse: a light microscopic analysis of neurons that project to the inferior colliculus. Journal of Comparative Neurology 292:381-391.
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Fekete, D.M., E.M. Rouiller, M.C. Liberman, and D.K. Ryugo (1984)
The central projections of intracellularly labeled auditory nerve fibers in cats. Journal of Comparative Neurology 229:432-450.
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Rouiller, E.M., and D.K. Ryugo (1984)
Intracellular marking of physiologically characterized cells in the ventral cochlear nucleus of the cat. Journal of Comparative Neurology 225:167-186.
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Benson, T.E., D.K. Ryugo, and J.W. Hinds (1984)
Effects of sensory deprivation on the developing mouse olfactory system: a light and electron microscopic, morphometric analysis. Journal of Neuroscience 4:638-653.
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Ryugo, D.K., and D.M. Fekete (1982)
Morphology of primary axosomatic endings in the anteroventral cochlear nucleus of the cat: A study of the endbulbs of Held. Journal of Comparative Neurology 210:239-257.
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Kiang, N.Y.S., J.M. Rho, C.C. Northrop, M.C. Liberman, and D.K. Ryugo (1982)
Hair-cell innervation by spiral ganglion cells in adult cats. Science 217:175-177.
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Ryugo, D.K., F.H. Willard, and D.M. Fekete (1981)
Differential afferent projections to the inferior colliculus from the cochlear nucleus in the albino mouse. Brain Research 210:342-349.
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